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Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021

Novel biomarker for predicting sepsis mortality: vitamin D receptor

Journal of International Medical Research https://doi.org/10.1177/03000605211034733
Murat Erdoğan, Hüseyin Avni FındıklıFirst

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VitaminDWiki

There are 2 easy ways to get past a VDR restriction
1) Take Vitamin D in high, infrequent doses
2) Take one of more supplements that have been proven to activate the receptor

Items in both categories VDR and Mortality:

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

Note: My father-in-law got sepsis in the hospital. I immediately gave him 200,000 IU of Vitamin D.
He left hospital 3 days later


I had not heard of an ELISA test kit for the VDR. This study got their $400 oil - (research purposes only) from https://www.mybiosource.com/


VitaminDWiki pages containing SEPSIS in title

Items found: 34
Title Modified
Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 16 Aug, 2021
Sepsis is both prevented and treated by Vitamin D 03 Jul, 2021
Vitamin C IV, which treats Sepsis, also treats COVID-19 - May 2020 01 Aug, 2020
3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020 03 Jun, 2020
Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020 27 Feb, 2020
Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 18 Dec, 2019
Fewer Burn problems if adequate Vitamin D – Less ICU, Hospital, Sepsis (10X) – Dec 2019 17 Dec, 2019
Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019 27 Jun, 2019
Sepsis mortality cut in half with Omega-3 – RCT Sept 2017 14 Apr, 2019
Sepsis reduced the Omega-3 response and half life – April 2019 14 Apr, 2019
Vitamin D for Sepsis prevention – June 2018 24 Jul, 2018
Omega-3 reduced cost of Sepsis by 2900 dollars per patient (12 RCT) – April 2018 24 Apr, 2018
Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018 22 Apr, 2018
Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018 06 Apr, 2018
Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018 14 Mar, 2018
Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017 20 Nov, 2017
Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023 23 Oct, 2017
Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017 04 Oct, 2017
Infant sepsis strongly associated with low vitamin D – Aug 2014 16 Aug, 2017
Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017 24 Jul, 2017
Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017 13 Jun, 2017
Severe Sepsis associated with very low vitamin D – Sept 2016 26 May, 2017
Increased Hospital, Sepsis deaths if low vitamin D – March 2014 21 May, 2017
Sepsis in first year of life is much more likely if preterm (low Vitamin D) – May 2017 10 May, 2017
Vitamin D might reduce sepsis 04 May, 2017
More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013 21 Sep, 2016
Neonates with sepsis had half the levels of vitamin D - 2015 30 Aug, 2016
Newborns with sepsis – 9 ng of vitamin D, without sepsis 19 ng – Aug 2015 30 Aug, 2016
Sepsis associated with low vitamin D - April 2012 22 Mar, 2016
1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014 20 Oct, 2015
Vitamin D and infectious diseases like RTI, TB and Sepsis – Nov 2014 24 Nov, 2014
More sepsis deaths in those entering hospital with low vitamin D – Jan 2014 07 Jun, 2014
ICU surgical patients with low vitamin D stayed longer and had more sepsis – Dec 2011 22 Jul, 2013
Sepsis bacteria can be killed by blue as well as UV light – Jan 2013 29 Jan, 2013

 Download the PDF from VitaminDWiki

Objective
There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis.

Methods
This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival.

Results
The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity.

Conclusions
VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis.


Created by admin. Last Modification: Monday August 16, 2021 20:52:47 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
16088 VDR days.jpg admin 16 Aug, 2021 19:08 35.75 Kb 56
16087 vdr multivariate.jpg admin 16 Aug, 2021 19:08 84.28 Kb 51
16086 VDR Sepsis mortality.jpg admin 16 Aug, 2021 19:07 72.43 Kb 56
16085 VDR biomarker for Sepsis mortality.pdf PDF - 2021 admin 16 Aug, 2021 19:07 367.78 Kb 36
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