Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors
Cancers (Basel). 2022 Jul 6;14(14):3295. doi: 10.3390/cancers14143295.
Orsolya Juhász 1, Noémi Jákob 2, Hajnalka Rajnai 2, Marcell Imrei 3 4, Miklós Garami 1
Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies.
Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary).
Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (p = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis (OR = 14.74). The rate of VDR expression differed significantly between tumor types (p <0.0001).
Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression.
Download the PDF from VitaminDWiki
Sometimes A Disease ==> deactivates VDR, typically poor VDR ==> increased risk
Suspect increased incidence of poor VDR in past 50 years
Now a person can survive a poor VDR and pass a poor VDR gene onto their offspring
This lack of the survival of the fittest may be a major reason for the increase of health problems, such as childhood cancers
Have been unable to find studies of trends of VDR incidence
| 544 |
studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
See also: | 50 |
studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Health problems include: Autoimmune (| 19 |
studies), Breast Cancer (| 24 |
studies), Colon Cancer (| 14 |
studies), Cardiovascular (| 23 |
studies), Cognition (| 16 |
studies), Diabetes (| 25 |
studies), Hypertension (| 9 |
studies), Infant (| 23 |
studies), Lupus (| 6 |
studies), Metabolic Syndrome (| 4 |
studies), Mortality (| 4 |
studies), Multiple Sclerosis (| 16 |
studies), Obesity (| 17 |
studies), Pregnancy (| 25 |
studies), Rheumatoid Arthritis (| 11 |
studies), TB (| 8 |
studies), VIRUS (| 41 |
studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk of diseases if poor VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Cancer is the most frequent health problem of VDR studies
Trend research of vitamin D receptor: Bibliometric analysis: 2021 PDF
VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
78 Cancer studies in VitaminDWiki were associated with poor VDR (as of July 2022)
This list is automatically updated
Items found: 93
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Title |
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Modified |
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10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
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23 Sep, 2016 |
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2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 |
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14 Nov, 2016 |
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2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017 |
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04 Mar, 2017 |
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2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012 |
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16 Sep, 2022 |
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8 ways that Cancer might be prevented by Vitamin D - June 2019 |
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26 Dec, 2019 |
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Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 |
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28 Mar, 2018 |
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Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 |
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19 Aug, 2017 |
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After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019 |
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04 Jun, 2019 |
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After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021 |
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20 Aug, 2021 |
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Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017 |
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28 Dec, 2016 |
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An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023 |
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13 Jan, 2024 |
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Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019 |
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14 Jun, 2019 |
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Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 |
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09 Dec, 2020 |
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Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010 |
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03 Oct, 2018 |
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Breast Cancer and Vitamin D review – March 2018 |
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17 Mar, 2019 |
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Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 |
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19 Oct, 2019 |
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Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019 |
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29 Jul, 2019 |
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Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012 |
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08 Jul, 2013 |
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Breast Cancer risk reduced if consume butyrate - Dec 2023 |
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23 Jan, 2024 |
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Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022 |
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31 Oct, 2022 |
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Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016 |
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06 Dec, 2016 |
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Breast Cancer, Vitamin D, and genes – Welsh Nov 2021 |
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09 Feb, 2022 |
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Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021 |
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10 Jul, 2021 |
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Cancer and the Vitamin D Receptor, a primer – Sept 2017 |
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01 Oct, 2017 |
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Cancer is leading cause of death - Vitamin D and Receptor activators help |
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09 Nov, 2019 |
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Cancer risks and Vitamin D Receptors – association is unclear – 2017 |
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19 Aug, 2017 |
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Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018 |
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01 Nov, 2018 |
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Cancers and Vitamin D Receptors, including change with race – Feb 2021 |
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24 Oct, 2021 |
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Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022 |
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15 Aug, 2022 |
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Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 |
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27 May, 2023 |
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Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 |
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15 Jan, 2021 |
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Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 |
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02 Aug, 2017 |
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Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 |
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22 Jan, 2020 |
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Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 |
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02 May, 2020 |
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Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019 |
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23 Aug, 2019 |
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Effects of Resveratrol against Lung Cancer in mice – Nov 2017 |
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28 Apr, 2019 |
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Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018 |
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08 Aug, 2018 |
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Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 |
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06 Jan, 2014 |
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Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 |
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15 Jun, 2017 |
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Genes breast cancer and vitamin D receptor - Sept 2010 |
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08 Jul, 2013 |
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Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019 |
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11 Apr, 2019 |
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High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016 |
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14 Nov, 2016 |
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Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016 |
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09 Aug, 2017 |
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Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
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03 May, 2015 |
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Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
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14 Dec, 2019 |
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Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021 |
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25 Oct, 2021 |
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Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
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13 Jun, 2019 |
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Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
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27 Jul, 2017 |
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Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 |
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06 Nov, 2019 |
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Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017 |
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19 Oct, 2017 |
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Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019 |
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11 Feb, 2019 |
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Oral Cancers - increased risk if low vitamin D or poor vitamin D genes |
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22 Jan, 2021 |
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Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013 |
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27 Feb, 2017 |
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Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
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14 Dec, 2017 |
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Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018 |
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10 Nov, 2018 |
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Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 |
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06 Dec, 2022 |
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Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies |
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18 Oct, 2021 |
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Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis Sept 2024 |
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06 Sep, 2024 |
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Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018 |
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15 Mar, 2019 |
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Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014 |
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13 Dec, 2015 |
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Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 |
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18 Oct, 2015 |
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Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 |
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27 Jul, 2022 |
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Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017 |
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06 Mar, 2017 |
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Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
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09 Nov, 2019 |
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Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018 |
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07 Jul, 2018 |
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Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 |
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09 Dec, 2018 |
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Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 |
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06 Jan, 2016 |
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Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015 |
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17 Mar, 2017 |
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The Role of Resveratrol in Cancer Therapy – Dec 2017 |
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27 Apr, 2019 |
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Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017 |
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26 Aug, 2017 |
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Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018 |
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17 Mar, 2018 |
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Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 |
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02 Mar, 2017 |
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Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017 |
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01 Mar, 2017 |
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Vitamin D receptor in breasts and breast cancer vary with race – March 2013 |
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08 Jul, 2013 |
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Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018 |
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16 Jun, 2018 |
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Vitamin D receptor may suppress skin cancer – Dec 2013 |
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27 Jan, 2017 |
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Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
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12 Nov, 2016 |
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Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 |
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17 Mar, 2016 |
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Vitamin D, Vitamin D Receptor and Cancer – Nov 2016 |
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05 Dec, 2016 |
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Vitamin D Receptor (Cancers OR Viruses) - many studies |
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02 Mar, 2024 |
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Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 |
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15 Nov, 2019 |
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Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024 |
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29 Jun, 2024 |
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Pancreatic Cancer protects itself deactivating HNF4A (which can be reactivated by the Vitamin D Receptor) – April 2024 |
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29 Jul, 2024 |
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Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 |
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25 Jul, 2017 |
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Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018 |
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15 Aug, 2018 |
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Vitexin activates the Vitamin D Receptor to fight Colon Cancer - Jan 2025 |
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15 Jan, 2025 |
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A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 |
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26 Mar, 2019 |
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How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020 |
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01 Nov, 2021 |
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Soft tissue sarcoma (Cancer) is assocated with poor Vitamin D Receptors and low levels of Vitamin D |
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25 Apr, 2025 |
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Soft tissue sarcoma (Cancer) is assocated with poor Vitamin D Receptors and low levels of Vitamin D |
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25 Apr, 2025 |
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Breast Cancer prevented in 5 ways via the Vitamin D Receptor – Oct 2024 |
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02 Nov, 2024 |
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Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies |
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14 Jun, 2019 |
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Oral Cancer and Vitamin D and VDR - several studies |
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11 Feb, 2024 |
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