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Lupus 3.8 X more likely if a poor Vitamin D Receptor – May 2019


Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients.

Clin Rheumatol. 2019 May 18. doi: 10.1007/s10067-019-04594-2.
Sun J1, Liu C2, Zhang S1, Yi B1, Gui M1, Zhang W1, Li YC3, Zhang H4.

VitaminDWiki

This is just an association, but what is the cause?

  1. Low VDR ==> less vitamin D in tissue ==>Active Lupus
  2. Active Lupus reduces VDR Activation
    • Note - several diseases, such as some cancers, are known to actively reduce the VDR
  3. Some unknown third item affects both

Items in both categories Lupus and Vitamin D Receptor are listed here:

  • Lupus category listing has 74 items along with related searches

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OBJECTIVE: Systemic lupus erythematosus (SLE) is characterized by uncontrolled production of pro-inflammatory cytokines. Vitamin D receptor (VDR) has potent anti-inflammatory activities. The aim of this study was to examine the correlation between VDR expression and inflammation and disease activity in patients with SLE.

METHODS:
Ninety-five SLE patients were recruited and divided into two groups, active and inactive, according to their SLE disease activity index (SLEDAI)-2 K, and 40 healthy individuals served as controls. The expression of VDR and NF-κB p65 in peripheral blood mononuclear cells (PBMCs) was determined by quantitative RT-PCR and Western blotting. VDR expression was correlated with inflammatory and diseases parameters in SLE patients. VDR regulation was also studied in THP-1 and Jurkat cell lines.

RESULTS:
PBMC VDR expression was downregulated in SLE patients, especially in the active SLE group. VDR mRNA levels were negatively correlated with SLEDAI-2 K (r = - 0.348, P = 0.001), Systemic Lupus International Collaborating Clinics (SLICC) renal activity scores (r = - 0.346, P = 0.014), and proteinuria (r = - 0.309, P = 0.002) and positively associated with serum complement C3 levels (r = 0.316, P = 0.002). Multiple stepwise regression analysis indicated that PBMC VDR downregulation was an independent risk factor for SLEDAI-2 K. VDR levels were also negatively correlated with NF-κB p65 (r = - 0.339, P = 0.001), TNF-α (r = - 0.268, P = 0.009), and IL-6 (r = - 0.313, P = 0.002) levels. In monocyte and T lymphocyte cell lines, TNF-α suppressed VDR expression, whereas 1,25-dihydroxyvitamin D blocked TNF-α-induced VDR downregulation.

CONCLUSION: PBMC VDR expression is inversely associated with disease activity and inflammation in SLE patients, and VDR downregulation is likely driven by inflammation.


13 studies cited this study as of June 2023

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10,300+ hits when search Google Scholar for lupus "vitamin D Receptor"

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VitaminDWiki - The risk of 44+ diseases at least double with poor Vitamin D Receptor


VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators


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Lupus 3.8 X more likely if a poor Vitamin D Receptor – May 2019        
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ID Name Comment Uploaded Size Downloads
11995 VDR Lupus.jpg admin 20 May, 2019 18.68 Kb 768
11994 VDR Lupus 2019.pdf admin 20 May, 2019 1.42 Mb 549