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Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021

Are vitamin D and vitamin D receptor levels different in children with developmental dysplasia of the hip?

Journal of Orthopaedic Surgery and Research (2021) 16:24 https://doi.org/10.1186/s13018-020-02162-y
Duran Topak , Muhammet Seyithanoglu , Fatih Dogar1 , Ali Aydin Karadeniz), Burak Tanriverdi2 ,
Firat 〇zan® and Okke§ Bilal1


Developmental dysplasia of the hip occurs once in every 1,000 live births

Rickets and Vitamin D Receptor:

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

 Download the PDF from VitaminDWiki

Introduction: Developmental dysplasia of the hip (DDH) is a common disorder and associated with significant morbidity of the hip joint. Several risk factors have been identified for DDH. The aim of this study is to investigate whether vitamin D and vitamin D receptor (VDR) levels differ in children with DDH and whether they have an effect on DDH development.

Materials and methods: A total of 40 (17 males, 23 females; 9 right hips, 16 left hips, 15 bilateral hips) children who were treated for developmental dysplasia and 40 (23 males, 17 females) healthy children without any musculoskeletal system and metabolic disorders were included in this study between January and June 2019. Blood samples from the DDH and control groups of children were collected to measure the serum levels of vitamin D, VDR, calcium (Ca), phosphorus (P), and alkaline phosphatase (ALP). The levels of Ca, P, and ALP were analyzed using the automated standard spectrophotometric laboratory method. The levels ofvitamin D and VDR in the samples were analyzed using enzyme-linked immunoassay.

Results: There were no significant differences in the serum levels of Ca, P, ALP, and vitamin D between the DDH and healthy groups (Ca 9.96± 0.47 vs. 9.92± 0.48mg/dL, respectively, p = 0.721;P 5.3 ± 0.94 vs.4.82 ± 0.88mg/dL, respectively, p = 0.23; ALP 252.22 ± 170.15vs.245.3 ±130.93 U/L, respectively, p = 0.839). However, serum VDR levels were significantly lower in childrenin the DDH group (5.77± 3.51ng/mL) than in the healthy control group (9.25 土 6.43 ng/mL) (p = 0.004).

Conclusions: In conclusion, we believe that low VDR levels can affectDDH regardless of theserum levels ofCa, P, ALP, and vitamin D. More comprehensive studies involving parents are needed to understand whether VDR levels mediate genetic transmission in DDH or not.

Created by admin. Last Modification: Sunday January 31, 2021 02:52:08 GMT-0000 by admin. (Version 3)

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14949 Hip displasia VDR half as activated.pdf PDF 2021 admin 31 Jan, 2021 02:46 592.71 Kb 73
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