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Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022


Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation

Age Ageing. 2022 Apr 1;51(4):afac079. doi: 10.1093/ageing/afac079. PDF is behind a $52 paywall
Mohsen Mazidi 1, Ian G Davies 2, Peter Penson 3, Toni Rikkonen 4, Masoud Isanejad 4

Clinical trials have suggested that increased 25-hydroxyvitamin D (25(OH)D) has positive effect on hand grip strength. This Mendelian randomisation (MR) was implemented using summary-level data from the largest genome-wide association studies on vitamin D (n = 73,699) and hand grip strength. Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, MR-Egger and leave-one-out were applied as sensitivity analysis. Results showed that genetically higher-serum 25(OH)D levels had a positive effect on both right hand grip (IVW = Beta: 0.038, P = 0.030) and left hand grip (IVW = Beta: 0.034, P = 0.036). There was a low likelihood (statistically insignificant) of heterogeneity and pleiotropy, and the observed associations were not driven by single single-nucleotide polymorphisms. Furthermore, MR pleiotropy residual sum and outlier did not highlight any outliers. In conclusion, our results highlighted the causal and beneficial effect of serum 25(OH) D on right- and left-hand grip strengths.


VitaminDWiki pages with HANDGRIP in title (5 as of April 2022)

This list is automatically updated

Items found: 5

VitaminDWiki pages with STRENGTH but not EVIDENCE in title (43 as of April 2022)

This list is automatically updated

Items found: 45
Title Modified
More muscle strength 80 years after being born in warm season (no surprise) – Nov 2022 26 Nov, 2022
Grip strength of children not improved by 800 IU Vitamin D daily (not nearly enough) – RCT Feb 2018 31 Oct, 2022
Age-related loss of strength (Dynapenia) 1.7X more likely if low Vitamin D – Sept 2022 16 Sep, 2022
Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022 09 Apr, 2022
Handgrip strength increased 9 percent in college athletes with 8 weeks of Omega-3 – RCT Feb 2022 18 Mar, 2022
Muscle Strength improved 1.4 to 19 percent by vitamin D3 (not D2) – systematic review June 2016 13 Feb, 2022
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 16 Oct, 2021
Exercise improves bone strength (good), but not bone mineral density (can be measured) – RCT Oct 2021 08 Oct, 2021
Low muscle strength predicts low vitamin D level in elderly – March 2021 06 May, 2021
Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 09 May, 2019
Vitamin D supplementation increases strength of lower muscles – Meta-analysis April 2019 01 May, 2019
Bone STRENGTH improved by 2800 IU of Vitamin D (not bone density) – RCT Oct 2018 06 Oct, 2018
Seniors getting Vitamin D (but no exercise) for 3 months failed to increase muscle strength – RCT June 2018 03 Jul, 2018
Poor handgrip strength in 5-year-old girls 3X more likely if low vitamin D – May 2018 24 May, 2018
Vitamin D weekly supplementation (Spinal Cord Injury athletes) increased handgrip strength – May 2018 15 May, 2018
Osteoporosis and low grip strength both associated with low vitamin D – Feb 2018 13 Feb, 2018
Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015 27 Jul, 2017
Muscle strength not increased by Vitamin D - 96 percent were not deficient – RCT April 2017 20 Jul, 2017
Muscle strength not increased by Vitamin D when 96 percent already had enough – RCT April 2017 30 Apr, 2017
Strength of evidence for Vitamin D – July 2014 26 Apr, 2017
Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016 08 Mar, 2017
Handgrip strength dropped by 20 percent in the last generation (perhaps due to lower vitamin D) - Feb 2017 02 Mar, 2017
Vitamin D increased muscle strength by 1% to 19% (varied with dose and duration) – review June 2016 22 Nov, 2016
Vitamin D increased muscle strength by 1 to 19 percent – review June 2016 22 Nov, 2016
Vitamin D increasing muscle strength may reduce knee pain – Feb 2016 22 Nov, 2016
Muscle strength is associated with vitamin D receptor gene variants – March 2016 12 Nov, 2016
Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 31 Oct, 2016
Muscle strength of Judo athletes increased 13 percent following single dose of 150,000 IU vitamin D – RCT Nov 2015 05 Nov, 2015
Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015 30 May, 2015
Bone strength increased when sow and piglets had enough Vitamin D and Phosphorus – April 2015 07 Apr, 2015
Pelvic floor muscle strength is low after giving birth if vitamin D deficient – March 2015 20 Mar, 2015
People with old burns improved muscle strength with 2200 IU average vitamin D – RCT Sept 2014 20 Dec, 2014
Increased Bone strength during military training – with just 800 IU of vitamin D and Calcium – RCT April 2014 29 Apr, 2014
Ankle strength and vitamin D lowest in winter, and were associated with more elderly falls – May 2012 09 Mar, 2014
Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 23 Dec, 2013
Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010 19 Dec, 2013
Muscle strength not increased by raising vitamin D to only 30 ng – RCT Aug 2012 19 Dec, 2013
Muscle strength in youth increased with 60,000 IU vitamin D per week and 1 g Calcium – April 2010 10 Aug, 2013
Vitamin K-2 (180 ug MK-7) helped both bone density and strength – RCT March 2013 18 Apr, 2013
National Standard summary and strength of evidence for vitamin D - June 2010 10 Nov, 2012
Vitamin D2 intervention increased elderly muscle strength – Nov 2010 10 Nov, 2012
National Institute of Health - Strength of Vitamin D Evidence 07 Nov, 2011
Lack of vitamin D and Calcium a world problem – strength of evidence etc – 2009 29 Sep, 2011
Higher vitamin D helps regain muscle strength after knee surgery – July 2011 01 Sep, 2011
Strength of evidence for Calcium at NLM – Oct 2010 09 Oct, 2010

VitaminDWiki - Some diseases reduce vitamin D getting to blood or cells

Some diseases restrict vitamin D by changing gene activation,
   by one or more of the following

  • Restrict conversion of light into vitamin D in the skin
  • Restrict oral absorption in the gut
  • Restrict semi-activation in the liver
  • Restrict free semi-activated vitamin D from getting to the kidneys
  • Restrict full activation in the kidneys
  • Restrict semi and fully activation in the cells
  • Restrict activated Vitamin D from entering cell mitochondria (VDR)
  • Destroy the vitamin D before it gets to the cells

Some diseases restrict vitamin D without changing genes

  • The disease just uses/consumes the vitamin D
  • The disease upsets the gut, which reduces bioavailability of oral form
    • unless a gut-friendly form is used

References



Mendelian randomisation probably ignores those Vitamin D genes that change levels in the cells

Genes such as: VDBP, CYP27B1, CYP1A4, CPY24A1, and the Vitamin D Receptor
Blood Test Misses a lot (VDW 3439)
click here for details


Created by admin. Last Modification: Sunday April 10, 2022 00:28:54 GMT-0000 by admin. (Version 9)
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