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Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D) – Dec 2017

Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer.

Oncol Lett. 2017 Dec;14(6):7538-7544. doi: 10.3892/ol.2017.7162. Epub 2017 Oct 10.
Ge N1, Chu XM1, Xuan YP1, Ren DQ2, Wang Y1, Ma K1, Gao HJ1, Jiao WJ1.

VitaminDWiki

Genetics category listing contains the following

253 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi by 2017 was speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 is an example of massive gene changes in another Cancer
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     shaded text and numbers in the chart were added by VitaminDWiki
Note: this study did not consider the Vitamin D Receptor gene


 Download the PDF from VitaminDWiki

Genes in study are marked with dashed ovals (invisible to Vitamin D tests)

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24A1 Active vitamin D is pissed away more than usual

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27B1 Kidney does not activate as much Vitamin D

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Lung cancer is a type of malignant tumor derived from the respiratory system, which is the leading cause of cancer-associated mortality worldwide, of which ~80% of cases are attributable to non-small cell lung cancer (NSCLC). A previous study demonstrated that 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3), derived from the vitamin D metabolic pathway contributes an antitumor effect. Aberrant expression of the essential enzyme encoding genes, Cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1), Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1), and Cytochrome P450 Family 24 Subfamily A Member 1 (CYP24A1) may be associated with lung cancer. However, a lack of evidence exists concerning the association between CYP27A1, CYP27B1, CYP24A1 expression and NSCLC. The aim of the present study was to investigate the functions of CYP27A1, CYP27B1 and CYP24A1 expression in NSCLC. Lung cancer tissue and para-carcinoma control tissue were collected from patients with NSCLC. Reverse transcription-quantitative polymerase chain reaction was applied to analyze CYP27A1, CYP27B1 and CYP24A1 mRNA expression in lung cancer tissues. An association analysis was performed between the aforementioned metabolic enzymes and patients with NSCLC age, gender, tumor node metastasis (TNM) stage, pathological type, differentiation and prognosis. CYP27B1 and CYP24A1 mRNA were upregulated in NSCLC compared with controls (P<0.05). However, no significant differences in CYP27A1 expression were observed between NSCLC and control. In addition, CYP24A1 expression was not associated with age, sex, smoking or TNM stage, but was associated with pathological type, differentiation and prognosis (P<0.05). CYP27B1 expression was significantly associated with TNM stage, differentiation, and prognosis, but not age, sex, smoking or pathological type. In conclusion, CYP27B1 and CYP24A1 may be considered as independent prognostic factors of NSCLC and may be novel therapeutic targets to assist clinical diagnosis, treatment and prognosis of the disease.

PMID: 29250167 PMCID: PMC5727627 DOI: 10.3892/ol.2017.7162

Created by admin. Last Modification: Sunday June 17, 2018 19:19:48 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
9960 CYP27B1.jpg admin 17 Jun, 2018 18:50 23.03 Kb 82
9959 CYP24A1.jpg admin 17 Jun, 2018 18:50 22.93 Kb 72
9958 Gene red blue.jpg admin 17 Jun, 2018 18:49 66.08 Kb 81
9957 Lung Cancer.pdf PDF 2018 admin 17 Jun, 2018 18:49 1.06 Mb 102
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