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Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019

Identification of Novel Markers of Prostate Cancer Progression, Potentially Modulated by Vitamin D

Appl. Sci. 2019, 9(22), 4923; https://doi.org/10.3390/app9224923
Rosario Caltabiano 1,Paola Castrogiovanni 2OrcID,Ignazio Barbagallo 3,Silvia Ravalli 2OrcID,Marta Anna Szychlinska 2OrcID,Vincenzo Favilla 4,Luigi Schiavo 5OrcID,Rosa Imbesi 2OrcID,Giuseppe Musumeci 2OrcID andMichelino Di Rosa 2,*OrcID

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Two Vitamin D genes associated with PC

Prostate cancer (PCa) is one of the most common cancers in men. The main risk factors associated with the disease include older age, family history of the disease, smoking, alcohol and race. Vitamin D is a pleiotropic hormone whose low levels are associated with several diseases and a risk of cancer. Here, we undertook microarray analysis in order to identify the genes involved in PCa. We analyzed three PCa microarray datasets, overlapped all genes significantly up-regulated, and subsequently intersected the common genes identified with the down-regulated genes transcriptome of LNCaP cells treated with 1α,25(OH)2D3, in order to identify the common genes involved in PCa and potentially modulated by Vitamin D. The analysis yielded 43 genes potentially involved in PCa and significantly modulated by Vitamin D. Noteworthy, our analysis showed that six genes (PRSS8, SOX4, SMYD2, MCCC2, CCNG2 and CD2AP) were significantly modulated. A Pearson correlation analysis showed that five genes out of six (SOX4 was independent), were statistically correlated with the gene expression levels of KLK3, and with the tumor percentage. From the outcome of our investigation, it is possible to conclude that the genes identified by our analysis are associated with the PCa and are potentially modulated by the Vitamin D.

Created by admin. Last Modification: Saturday November 16, 2019 16:29:36 GMT-0000 by admin. (Version 4)

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12975 Prostate Cancer Genes.jpg admin 15 Nov, 2019 18:20 40.29 Kb 141
12974 Prostate Cancer and Vitamin D genes.pdf PDF 2019 admin 15 Nov, 2019 18:20 3.72 Mb 68
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