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Which Vitamin D Receptor activator for which health problem - Perplexity AI June 2024

1st question VDR Activators

Various things increase the activation of the vitamin D receptor - such as Magnesium, Omega-3, Resveratrol, Quercetin , Zinc, Boron, ginger, curcumin, Sulfroaphane, Butyrate, Berberine etc. Are some activators best at treating some VDR specific problems?
The activation of the Vitamin D Receptor (VDR) is crucial for various physiological processes, including calcium homeostasis, bone metabolism, cardiovascular health, and immune function. Different activators of the VDR can have specific effects on these processes, and some may be more effective for treating particular VDR-related issues.

Cardiovascular Health

Vitamin D and its receptor activators, such as calcitriol and paricalcitol, have been shown to have significant benefits for cardiovascular health. These benefits include reducing hypertension, cardiac hypertrophy, and vascular calcification. For instance, paricalcitol has demonstrated a favorable profile in reducing cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) .

Immune Function and Inflammation

Vitamin D receptor activation also plays a role in modulating the immune system and reducing inflammation. Quercetin, a flavonoid, has been shown to directly interact with the VDR, potentially enhancing its activation and subsequent immune-modulatory effects . This can be particularly beneficial in conditions characterized by chronic inflammation and immune dysregulation.

Bone Health

VDR activators are essential in managing bone health, particularly in conditions like osteoporosis and secondary hyperparathyroidism. Calcitriol and its analogs are commonly used to manage these conditions by regulating calcium and phosphate metabolism, thereby improving bone density and reducing fracture risk .

Renal Health

In CKD, VDR activation is crucial for managing mineral and bone disorders, as well as reducing cardiovascular risks. Selective VDR activators like paricalcitol are preferred due to their ability to suppress parathyroid hormone (PTH) with minimal calcemic and phosphatemic effects, thus reducing the risk of vascular calcification and improving patient outcomes .

Specific Activators and Their Effects

  • Magnesium: Essential for the proper functioning of the VDR and enhancing the effects of vitamin D.
  • Omega-3 Fatty Acids: May have synergistic effects with vitamin D in reducing inflammation and improving cardiovascular health.
  • Resveratrol: Known for its anti-inflammatory and antioxidant properties, it may enhance VDR activation and provide cardiovascular and metabolic benefits.
  • Quercetin: Directly interacts with the VDR, enhancing its activation and providing immune-modulatory and anti-inflammatory effects .
  • Zinc and Boron: Important for bone health and may enhance the effects of vitamin D on the VDR.
  • Ginger and Curcumin: Known for their anti-inflammatory properties, they may support VDR activation and provide benefits in inflammatory conditions.
  • Sulforaphane: An antioxidant that may enhance VDR activation and provide protective effects against oxidative stress.
  • Butyrate: A short-chain fatty acid that may enhance VDR activation and provide benefits in gut health and inflammation.
  • Berberine: Known for its metabolic benefits, it may enhance VDR activation and provide cardiovascular and metabolic health benefits.

Conclusion

Different VDR activators can be more effective for specific health issues. For cardiovascular and renal health, selective VDR activators like paricalcitol are preferred. For immune modulation and inflammation, compounds like quercetin and resveratrol may be more beneficial. For bone health, traditional VDR activators like calcitriol and its analogs are commonly used. The choice of VDR activator should be tailored to the specific health condition being treated, considering the unique benefits and mechanisms of each activator.
Click here for 20 references


2nd question: Which activator for which health problem?

Various things increase the activation of the vitamin D receptor - such as Magnesium, Omega-3, Resveratrol, Quercetin , Zinc, Boron, ginger, curcumin, Sulfroaphane, Butyrate, Berberineetc. Do any of them have the possibility of treating Cancers or COVID?
Several of the compounds mentioned—Omega-3 fatty acids, resveratrol, quercetin, and zinc—have shown potential in treating cancers, though their efficacy and mechanisms vary. Here is a detailed overview based on the provided sources:

Omega-3 Fatty Acids

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been studied for their potential benefits in cancer treatment. They exhibit anti-inflammatory properties and may help in reducing tumor growth and enhancing the efficacy of chemotherapy. For instance, omega-3 fatty acids have been shown to preserve muscle mass and function in cancer patients, potentially reduce inflammatory responses during chemotherapy, and increase the response rate to chemotherapy in small studies. However, the evidence is mixed, and more research is needed to confirm these benefits.

Resveratrol

Resveratrol, a polyphenol found in grapes, berries, and peanuts, has demonstrated anticancer properties in preclinical studies. It affects various stages of carcinogenesis by modulating signal transduction pathways that control cell division, growth, apoptosis, inflammation, angiogenesis, and metastasis. Despite promising preclinical results, clinical trials have faced challenges due to resveratrol's poor bioavailability and potential toxicity at high doses. Enhancing its bioavailability through new formulations or developing more potent analogues could improve its therapeutic potential.

Quercetin

Quercetin, a flavonoid found in many fruits and vegetables, has shown anticancer effects by inhibiting cell proliferation, inducing apoptosis, and enhancing the efficacy of chemotherapy drugs. It has been studied in various cancer types, including gastrointestinal, blood, lung, and prostate cancers. However, its clinical application is limited by poor solubility, low bioavailability, and rapid metabolism. Combining quercetin with other treatments or using nanotechnology-based delivery systems may overcome these limitations.

Zinc

Zinc is a trace element that plays a crucial role in the immune system and cell growth. It has been studied as a complementary treatment for cancer patients, particularly for reducing radiotherapy-induced inflammation of oral and oropharyngeal mucosa. While zinc supplementation has shown some benefits in reducing mucositis and improving taste and oral pain, it does not appear to significantly impact weight, quality of life, fatigue, or survival.

COVID-19

While the provided sources do not specifically address the use of these compounds in treating COVID-19, some of them have been studied for their potential antiviral and immune-boosting properties. For example, omega-3 fatty acids and resveratrol have anti-inflammatory effects that could theoretically benefit COVID-19 patients by modulating the immune response and reducing inflammation. However, more research is needed to establish their efficacy and safety in the context of COVID-19.

In summary, while omega-3 fatty acids, resveratrol, quercetin, and zinc show promise in cancer treatment, their effectiveness varies, and more research is needed to fully understand their potential and optimize their use. Their role in treating COVID-19 remains speculative and requires further investigation.
20 references


VitaminDWiki – Vitamin D Receptor category contains

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


VitaminDWiki – The Vitamin D Receptor is associated with many health problems

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


VitaminDWiki – Vitamin D Receptor

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk
increase
Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
13Sepsis
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4.1Vitiligo
4Polycystic ovary syndrome
3.8Lupus
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
9X in women
3Parkinson’s
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Cardio
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Gout
1.5Pertussis
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Hypertension
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant