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Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016

Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder

Journal of Child Psychology and Psychiatry, First published: Oct 2016 DOI: 10.1111/jcpp.12652
Khaled Saad, Ahmed A. Abdel-Rahman, Yasser M. Elserogy, Abdulrahman A. Al-Atram, Amira A. El-Houfey, Hisham A. K. Othman, Geir Bjørklund, Feiyong Jia, Mauricio A. Urbina, Mohamed Gamil M. Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A. Abd El-Baseer, Ahmed E. Ahmed, Ahmad M. Abdel-Salam

VitaminDWiki Summary
At start4 months later
CARS
Autism Rating Scale
3730
Irritability2210
Social Responsiveness
   lower is better
7571
Hyperactivity2616
Lethargy1811
Inappropriate Speech74
Vitamin D
all had > 20 ng at start
26 ng46 ng

VitaminDWiki speculates even more improvements if

  • Only considered those children gettting > 40 ng of Vitamin D
  • Had started with a loading dose (4 months is a fairly short time)
  • Give more Vitamin D to children for poor Vitamin D Receptor - which increases the risk of Autism by 2X
    Note: Vitamin D Receptor test costs $23.
    Wild guess: 50% more vitamin D would be needed for those with poor VDR
  • Had added some cofactors - Magnesium and Omega-3
    Both are often mentioned with Autism and both deal with poor Vitamin D Receptors

See also VitaminDWiki

1000 IU per 25 lbs.jpg
   This study used a dose which was 3X larger: 300 IU/kg == 3,000 IU/25 lbs
Files in both categories of Intervention AND Autism

 Download the PDF from VitaminDWiki
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Background:
Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children.

Methods
This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281.

Results
Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.

Conclusions
This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.


Social Responsiveness (SRS) of 22,000 Japanese school children - lower score is better
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Attached files

ID Name Comment Uploaded Size Downloads
9510 Autism RCT T5.jpg admin 13 Mar, 2018 20:47 94.81 Kb 28
9509 Autism RCT.jpg admin 13 Mar, 2018 20:47 72.46 Kb 31
9508 Autism RCT.pdf PDF 2018 admin 13 Mar, 2018 20:46 160.31 Kb 7
7403 SRS.jpg admin 27 Nov, 2016 02:23 24.84 Kb 686
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