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Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014

Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis.

Neurol Sci. 2014 Jul 10. [Epub ahead of print]
Lee YH1, Kim JH, Song GG.
1Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea, lyhcgh at korea.ac.kr.

The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson's disease (PD) and Alzheimer's disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis.

The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259-0.884, p = 0.018).

We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144-1.746, p = 0.001).

Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591-0.900, p = 0.034; OR 0.591, 95 % CI 0.431-0.810, p = 0.001; OR 0.580, 95 % CI 0.361-0.931, p = 0.024, respectively).

This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility.

PMID: 25008423

References

  1. Boada M, Antunez C, Lopez-Arrieta J, Caruz A, Moreno-Rey C, Ramirez-Lorca R et al (2012) Estrogen receptor alpha gene variants are associated with Alzheimer’s disease. Neurobiol Aging 33(1):198 e15–198 e24 CrossRef
  2. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM et al (2013) Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: the PDGene database. PLoS Genet 8(3):e1002548 CrossRef
  3. Fernandes de Abreu DA, Eyles D, Feron F (2009) Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 34(Suppl 1):S265–S277 CrossRef
  4. Maruotti N, Cantatore FP (2010) Vitamin D and the immune system. J Rheumatol 37(3):491–495 CrossRef
  5. Vinh Quoc Luong K, Thi Hoang Nguyen L (2012) Vitamin D and Parkinson’s disease. J Neurosci Res 90(12):2227–2236 CrossRef
  6. Valdivielso JM, Fernandez E (2006) Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 371(1–2):1–12 CrossRef
  7. Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S et al (1997) Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol 11(8):1165–1179 CrossRef
  8. Morrison NA, Yeoman R, Kelly PJ, Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci USA 89(15):6665–6669 CrossRef
  9. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K et al (1997) A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12(6):915–921 CrossRef
  10. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338(2):143–156 CrossRef
  11. Yasovanthi J, Venkata Karunakar K, Sri Manjari K, Pulla Reddy B, Ajeya Kumar P, Sesha Charyulu M et al (2011) Association of vitamin D receptor gene polymorphisms with BMD and their effect on 1, 25-dihydroxy vitamin D3 levels in pre- and postmenopausal South Indian women from Andhra Pradesh. Clin Chim Acta 412(7–8):541–544 CrossRef
  12. Petersen MS, Bech S, Christiansen DH, Schmedes AV, Halling J (2014) The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson’s disease in the Faroe Islands. Neurosci Lett 561:74–79 CrossRef
  13. Torok R, Torok N, Szalardy L, Plangar I, Szolnoki Z, Somogyvari F et al (2013) Association of vitamin D receptor gene polymorphisms and Parkinson’s disease in Hungarians. Neurosci Lett 551:70–74 CrossRef
  14. Liu HX, Han X, Zheng XP, Li YS, Xie AM (2013) Association of vitamin D receptor gene polymorphisms with Parkinson disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(1):13–16
  15. Lv Z, Tang B, Sun Q, Yan X, Guo J (2013) Association study between vitamin d receptor gene polymorphisms and patients with Parkinson disease in Chinese Han population. Int J Neurosci 123(1):60–64 CrossRef
  16. Han X, Xue L, Li Y, Chen B, Xie A (2012) Vitamin D receptor gene polymorphism and its association with Parkinson’s disease in Chinese Han population. Neurosci Lett 525(1):29–33 CrossRef
  17. Kim JS, Kim YI, Song C, Yoon I, Park JW, Choi YB et al (2005) Association of vitamin D receptor gene polymorphism and Parkinson’s disease in Koreans. J Korean Med Sci 20(3):495–498 CrossRef
  18. Gezen-Ak D, Dursun E, Bilgic B, Hanagasi H, Ertan T, Gurvit H et al (2012) Vitamin D receptor gene haplotype is associated with late-onset Alzheimer’s disease. Tohoku J Exp Med 228(3):189–196 CrossRef
  19. Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD (2011) The vitamin D receptor gene is associated with Alzheimer’s disease. Neurosci Lett 504(2):79–82 CrossRef
  20. Gezen-Ak D, Dursun E, Ertan T, Hanagasi H, Gurvit H, Emre M et al (2007) Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med 212(3):275–282 CrossRef
  21. Wang L, Hara K, Van Baaren JM, Price JC, Beecham GW, Gallins PJ et al (2012) Vitamin D receptor and Alzheimer’s disease: a genetic and functional study. Neurobiol Aging 33(8):e1–e9 CrossRef
  22. Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (2003) Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet 117B(1):114–117 CrossRef
  23. Lin CH, Chen KH, Chen ML, Lin HI, Wu RM (2014) Vitamin D receptor genetic variants and Parkinson’s disease in a Taiwanese population. Neurobiol Aging 35(5):1212 e11–1212 e13 CrossRef
  24. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG (2007) PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 27(9):827–833 CrossRef
  25. Lee YH, Bae SC, Choi SJ, Ji JD, Song GG (2011) Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 38(6):3643–3651 CrossRef
  26. Lee YH, Harley JB, Nath SK (2006) Meta-analysis of TNF-alpha promoter −308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14(3):364–371 CrossRef
  27. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558 CrossRef
  28. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188 CrossRef
  29. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634 CrossRef
  30. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30 CrossRef
  31. Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D (1998) The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants. J Bone Miner Res 13(11):1691–1699 CrossRef
  32. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV et al (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367(6460):284–287 CrossRef

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