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Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021

The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss

Meta Gene.Volume 27, February 2021, https://doi.org/10.1016/j.mgene.2020.100833
ZohrehSalariaNasrollahSaleh-GoharibMonireRezapouraAhamadKhosravicHadiTavakkolidEhsanSalarkiacFatemehKarami-Robatie

VitaminDWiki

Pages listed in BOTH the categories Pregnancy and Vitamin D Receptor


The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Objective
Recurrent pregnancy loss is one of the most common medical events that occur in the first and second trimesters. Hence, this study aimed to evaluate the relationship between vitamin D receptor (VDR) polymorphisms (rs2228570 and rs7975232) and the risk of recurrent pregnancy loss. The effect of rs2228570 polymorphism on protein stability was also predicted via in silico investigation.

Methods
This cross-sectional study was conducted on 52 women with recurrent pregnancy loss and 52 control women without pregnancy loss. We used the polymerase chain reaction technique to amplify the polymorphism regions on the chromosome. The PCR products were cut by FokI and ApaI restriction enzymes and the obtained data were analyzed.

Results
Our results showed the case group consisted of 32.7% wild type, 65.4% heterozygote, and 1.9% homozygote genotypes for polymorphism rs7975232.The controls included 48.1% wild type, 42.3% heterozygote, and 9.6% homozygote genotypes. There was a significant difference between polymorphism rs7975232 and recurrent pregnancy loss (P = 0.034). These genotypes for rs2228570 polymorphism were53.8% wild type, 38.5% heterozygote, and 7.7% homozygote. However, the control group included 80.8% wild type, 15.4% heterozygote, and 3.8% homozygote. There was a significant difference between polymorphism rs2228570 and recurrent pregnancy loss (P = 0.014).

Conclusion
We found a significant difference between VDR rs2228570 and rs7975232 genetic variants with recurrent pregnancy loss. Protein stability was also decreased following single nucleotide polymorphism in VDR rs2228570.


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