The relationship between vitamin D receptor (VDR) rs2228570 and rs7975232 genetic variants and the risk of recurrent pregnancy loss
Meta Gene.Volume 27, February 2021, https://doi.org/10.1016/j.mgene.2020.100833
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – Meta-Analysis Jan 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Recurrent pregnancy loss is one of the most common medical events that occur in the first and second trimesters. Hence, this study aimed to evaluate the relationship between vitamin D receptor (VDR) polymorphisms (rs2228570 and rs7975232) and the risk of recurrent pregnancy loss. The effect of rs2228570 polymorphism on protein stability was also predicted via in silico investigation.
This cross-sectional study was conducted on 52 women with recurrent pregnancy loss and 52 control women without pregnancy loss. We used the polymerase chain reaction technique to amplify the polymorphism regions on the chromosome. The PCR products were cut by FokI and ApaI restriction enzymes and the obtained data were analyzed.
Our results showed the case group consisted of 32.7% wild type, 65.4% heterozygote, and 1.9% homozygote genotypes for polymorphism rs7975232.The controls included 48.1% wild type, 42.3% heterozygote, and 9.6% homozygote genotypes. There was a significant difference between polymorphism rs7975232 and recurrent pregnancy loss (P = 0.034). These genotypes for rs2228570 polymorphism were53.8% wild type, 38.5% heterozygote, and 7.7% homozygote. However, the control group included 80.8% wild type, 15.4% heterozygote, and 3.8% homozygote. There was a significant difference between polymorphism rs2228570 and recurrent pregnancy loss (P = 0.014).
We found a significant difference between VDR rs2228570 and rs7975232 genetic variants with recurrent pregnancy loss. Protein stability was also decreased following single nucleotide polymorphism in VDR rs2228570.