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Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review April 2020

Vitamin D and Immunity in Infants and Children

Nutrients 2020, 12, 1233; doi:10.3390/nu12051233
Geneviève Mailhot and John H. White

Vitamin D signaling in innate immunity

Highlights added by VitaminDWiki


Vitamin D Genes

Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

CYP27B1 category listing contains the following

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
in Visio for 2023

Items in both categories Infant-Child and VDR are listed here:

Items in both categories Infant-Child and Immunity are listed here:

Items in both categories Infant-Child and Diabetes are listed here:

Items in both categories Infant-Child and Multiple Sclerosis are listed here:

Items in both categories Infant-Child and Breathing are listed here:

Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
click on chart to see the study

 Download the PDF from VitaminDWiki

The last couple of decades have seen an explosion in our interest and understanding of the role of vitamin D in the regulation of immunity. At the molecular level, the hormonal form of vitamin D signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor. The VDR and vitamin D metabolic enzymes are expressed throughout the innate and adaptive arms of the immune system. The advent of genome-wide approaches to gene expression profiling have led to the identification of numerous VDR-regulated genes implicated in the regulation of innate and adaptive immunity. The molecular data infer that vitamin D signaling should boost innate immunity against pathogens of bacterial or viral origin. Vitamin D signaling also suppresses inflammatory immune responses that underlie autoimmunity and regulate allergic responses. These findings have been bolstered by clinical studies linking vitamin D deficiency to increased rates of infections, autoimmunity, and allergies. Our goals here are to provide an overview of the molecular basis for immune system regulation and to survey the clinical data from pediatric populations, using randomized placebo-controlled trials and meta-analyses where possible, linking vitamin D deficiency to increased rates of infections, autoimmune conditions, and allergies, and addressing the impact of supplementation on these conditions.
Partial Table of Contents

  • 2. Overview of the Molecular Basis for the Non-Classical Actions of Vitamin D in the Immune System
    • Antiviral Activity of Vitamin D Signaling: Specific Reference to COVID-19.
  • 3. Vitamin D and Infectious Diseases in Pediatric Populations.
  • 4. Crohn’s Disease
  • 5. Vitamin D Deficiency and Dental Caries
  • 6. Links between Vitamin D Deficiency and Autoimmune Conditions in Pediatric Populations.
    • 6.1. Juvenile-Onset Type 1 Diabetes.
    • 6.2. Multiple Sclerosis
    • 6.3. Other Autoimmune Conditions
  • 7. Allergic Conditions
    • 7.1. Asthma
    • 7.2. Other Allergic Conditions
      • 7.2.1. Atopic Dermatitis
      • 7.2.2. Food Allergies
      • 7.2.3. Allergic Rhinitis and Aeroallergen Sensitization

Created by admin. Last Modification: Monday April 27, 2020 17:24:12 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
13766 Signaling innate immunity.jpg admin 27 Apr, 2020 15:20 50.67 Kb 436
13765 Vitamin D and Immunity in Infants and Children.pdf PDF 2020 admin 27 Apr, 2020 15:20 563.95 Kb 363