Association between FokI polymorphism of Vitamin D Receptor gene and lumbar spine disc degeneration: A systematic review and meta-analysis
Am J Phys Med Rehabil. 2020 Sep 14. doi: 10.1097/PHM.0000000000001588
Rosa Giannina Castillo-Avila 1, Thelma Beatriz González-Castro 2, Carlos Alfonso Tovilla-Zárate 3, Isela Esther Juárez-Rojop 1, María Lilia López-Narváez 4, José Manuel Rodríguez-Pérez 5, Samuel Suárez-Méndez 1
Items in both categories Osteoporosis and Vitamin D Receptor:
- Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018
- Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Yes, poor backs can be due to genetics and can run in families
- Back Pain category listing has
43 items along with related searches - Back pain cured with vitamin D – book May 2014
- Back pain extremely associated with low level of vitamin D – May 2014
- Back pain reduced for 95 percent of those who took vitamin D - 2003
- This file resulted in the creation of VitaminDWiki in 2010
- Lumbar degenerative disc diseases might be fought by Vitamin D Receptor activation– many studies
- Spinal disc degeneration is associated with vitamin D receptor genes, and others – March 2013
- Degeneration of lumbar disc 2.5 X more likely if poor Vitamin D receptor (not detected by test) Feb 2018
- Lumbar disc degeneration 30 percent more likely if poor Vitamin D Receptor – May 2019
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
Objective: The aim of the present meta-analysis was to explore the association between FokI polymorphism of the VDR gene and lumbar spine disc degeneration.Design: The search was performed in PubMed, Scopus and Web of Science databases up to January 2020. We selected nine studies that comprised a total of 1549 cases and 1672 controls. The association analysis included the allelic, dominant, recessive, homozygous and heterozygous genetic models. Odds ratios with 95% confidence intervals were used to evaluate the association. The NOS scale was used to measure the quality of the studies included in the analyses; a cut-off of 6 stars was applied.
Results: This meta-analysis indicated that FokI polymorphism is significantly associated with lumbar degenerative disc disorder and disc herniation in the homozygous (OR 1.77, CI95% 1.23-2.54, Z p value 0.002, Q p value 0.416) and recessive (OR 1.53; CI95% 1.23-1.90, Z p value <0.000, Q p value 0.224) models.
Conclusions: Our study indicates that the VDR gene FokI polymorphism may be correlated with the risk of developing a lumbar degenerative disc disorder and disc herniation. However, the small sample population studied and the lack of an evaluation of environmental factors must be taken as limitations in the present meta-analysis.
Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020Printer Friendly Follow this page for updates5333 visitors, last modified 17 Sep, 2020, This page is in the following categories (# of items in each category)