- Vitamin D: A master example of nutrigenomics
- 4+ VitaminDWiki pages have CARLBERG in the title
- 21 Carlberg publications 2021 - Feb 2024
- VitaminDWiki – Vitamin D Receptor is associated in over 58 autoimmune studies
- VitaminDWiki – Cancer increases if poor Vitamin D Receptor
- VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) contains
Redox Biology 62 (2023) 102695 https://doi.org/10.10167j.redox.2023.102695
Carsten Carlberg a,b’ c.carlberg at pan.olsztyn.pl , Marianna Raczyk a, Natalia Zawrotna a
a Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, PL-10748, Olsztyn, Poland
b School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland
Vitamin D target genes Epigenome Transcriptome Immune system Personalized nutrition
Nutrigenomics attempts to characterize and integrate the relation between dietary molecules and gene expression on a genome-wide level. One of the biologically active nutritional compounds is vitamin D3, which activates via its metabolite 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) the nuclear receptor VDR (vitamin D receptor). Vitamin D3 can be synthesized endogenously in our skin, but since we spend long times indoors and often live at higher latitudes where for many winter months UV-B radiation is too low, it became a true vitamin. The ligand- inducible transcription factor VDR is expressed in the majority of human tissues and cell types, where it modulates the epigenome at thousands of genomic sites. In a tissue-specific fashion this results in the up- and downregulation of primary vitamin D target genes, some of which are involved in attenuating oxidative stress. Vitamin D affects a wide range of physiological functions including the control of metabolism, bone formation and immunity. In this review, we will discuss how the epigenome- and transcriptome-wide effects of 1,25 (OH)2D3 and its receptor VDR serve as a master example in nutrigenomics. In this context, we will outline the basis of a mechanistic understanding for personalized nutrition with vitamin D3.
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- Vitamin D and Aging: Central Role of Immunocompetence
- Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics.
- Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis.
- In Vivo Regulation of Signal Transduction Pathways by Vitamin D Stabilizes Homeostasis of Human Immune Cells and Counteracts Molecular Stress.
- Intervention Approaches in Studying the Response to Vitamin D3 Supplementation.
- Genomic signaling of vitamin D.
- Vitamin D: A master example of nutrigenomics.
- Nutrigenomics in the context of evolution.
- Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland.
- A Pleiotropic Nuclear Hormone Labelled Hundred Years Ago Vitamin D.
- A Single Oral Vitamin D3 Bolus Reduces Inflammatory Markers in Healthy Saudi Males.
- A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females.
- Vitamin D in the Context of Evolution.
- Gene-Regulatory Potential of 25-Hydroxyvitamin D3 and D2.
- Vitamin D and Its Target Genes.
- Time-Resolved Gene Expression Analysis Monitors the Regulation of Inflammatory Mediators and Attenuation of Adaptive Immune Response by Vitamin D.
- Vitamin D and Pigmented Skin.
- Transcriptome-Wide Profile of 25-Hydroxyvitamin D3 in Primary Immune Cells from Human Peripheral Blood.
- Replacing Saturated Fat with Polyunsaturated Fat Modulates Peripheral Blood Mononuclear Cell Gene Expression and Pathways Related to Cardiovascular Disease Risk Using a Whole Transcriptome Approach.
- Vitamin D and the risk for cancer: A molecular analysis.
- A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes.
VitaminDWiki – Cancer increases if poor Vitamin D Receptor
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor and Cancer
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
- Breast Cancer and VDR
- Colon Cancer and VDR
- Prostate Cancer and VDR
- Skin Cancer and VDR
- Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) contains
- The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
- Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
- Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
- Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
- Quercetin and Curcumin in the case of Resveratro
18 articles in both of the categories Resveratrol and Vitamin D Receptor
Vitamin D Receptor activation in cells varies by 100 X - Carlberg April 2023
- Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Resveratrol improves health (Vitamin D receptor, etc.)
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Vitamin D Receptor
- Resveratol helps vitamin D bind to cells
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
205 visitors, last modified 11 Feb, 2024,This page is in the following categories (# of items in each category)
- Breast Cancer and VDR