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Benefits of Vitamin D often limited by genes


Vitamin D (Cholecalciferol in blood, fat, breast milk)
Processing by Liver into 'Calcidiol is limited by
        CYP24A1 gene
Outside of the liver Calcidiol' production is limited by
       CYP2R1 gene
Measured Vit D = Calcidiol

         the following genes are invisible to vit D test
Only a portion of Calcidiol is bio-available
      the rest is tied up by Vit D Binding Protein = GC
Kidney excreting = Calcidiol
      is a function of CYP24A1 gene
Active Vit D (from Kidney etc.) = Calcitriol
Vitamin D availability in the cells
      is a function of Vit D receptor gene

It seems that ~30% of the people do not get full benefit from Vitamin D due to gene limitations
It seems that 20% of limitations due to genes are invisible to Vitamin D blood tests


Genetics has the following charts
Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)
http://www.vitamindwiki.com/tiki-index.php?page_id=1586
Click on chart for details

See also VitaminDWiki

Vitamin D Receptor category has the following

460 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 43 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (19 studies), Colon Cancer (12 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (6 studies), Infant (17 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Benefits of Vitamin D often limited by genes        
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