Genetics

Gene	# of pages	Location
CYP27A1	449 (Sept 2019)	Liver
*CYP2R1	826 (Sept 2019)	Liver & Tissue
CYP27B1	1430 (Sept 2019)	Kidney & Tissue
CYP24A1	28 in title - May 2022]	excrete excess

Id	Page	Hits	Last modification	Creator	Categories
76	Genetics Determines Vitamin D Response	6075	19 Aug, 2010 12:05	admin	About D - more info. Technical D Genetics
208	How vitamin D helps the lung via vitamin D-binding protein - May 2010	8291	22 Oct, 2017 20:33	admin	Breathing Technical D Genetics Vit D Binding Protein
245	Genome-wide association study of circulating vitamin D levels -May 2010	3972	27 May, 2011 15:11	admin	Genetics
362	Epigenetics and vitamin D – June 2010 clips from the web	5920	15 Jun, 2022 01:42	admin	Skin - Dark Genetics
385	Genes May Play a Role in Vitamin D Deficiency – June 2010	8973	23 Jan, 2016 18:14	admin	Deficiency of Vitamin D Genetics
520	Gene variations were not associated with risk of colorectal cancer in Czech – June 2010	2787	02 Jul, 2010 10:40	admin	Cancer - Colon Genetics
592	Epigenetics of prostate cancer and vitamin D – June 2010	5447	09 Jul, 2013 16:30	admin	Cancer - Prostate Genetics
645	The more the African Ancestry, the lower the vitamin D level – July 2010	15601	10 Jan, 2019 11:15	admin	Skin - Dark Genetics
698	MS due to low level of vitamin D may be due to a specific gene – July 2010	4943	05 Mar, 2012 22:29	admin	Multiple Sclerosis Technical D Genetics
704	MS and vitamin D may be related by HLA gene – March 2010	5095	05 Mar, 2012 22:29	admin	Multiple Sclerosis Genetics

Genetics

99772 visitors, last modified 23 May, 2024,

99772 visitors, last modified 23 May, 2024,

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- Reasons for low response to vitamin D Response to Vitamin D - many studies Health Problems and D Overview Tuberculosis and Vitamin D People who do not catch COVID have a gene mutation (HLA-DQA2) which INCREASES cellular Vitamin D – June 2024 VitaminDWiki interview and transcript - Lahore Jan 2022 A poor gene (SDR42E1) can greatly reduce Vitamin D from the sun (may be prevalent in the Middle East) – Aug 2024 Vitamin D Receptor CYP24A1 gene and Vitamin D - many studies Risk of Prostate Cancer metastatic death cut in half if 2 vitamin D genes are not downregulated (or perhaps if higher D)– Aug 2024 Suppression of CYP24A1 gene got more Vitamin D to cells to fight Breast Cancer – March 2023 Schizophrenia associated with low Vitamin D and CYP2R1, CYP27B1, and CYP24A1 – June 2024 Coimbra protocol using high-dose Vitamin D is safe – April 2022 Calcifediol (semi-activated vitamin D, Calcidiol) – Oct 2023 Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 Glutathione and Vitamin D synergism - many studies Calcitriol Low-cost Vitamin D testers (two yes-no tests for 11 dollars) - 2024 2260 diseases found to be fought by fully-activated Vitamin D (Calcitriol) – July 2024 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 Resveratrol improves health (Vitamin D receptor, etc.) Vitamin D fortification of the innate immune system can be limited by 15 genes – April 2020 Vitamin D Receptor affects 10 other genes - June 2024 Nanoemulsion Vitamin D may be a substantially better form Infections and low vitamin D Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 Response to Vitamin D – 25% high, 24% low (ignores other than genes) – July 2024 Vitamin D Binding Protein Personalized treatment of Vitamin D Acupuncture of scalp activates Vitamin D genes CYP27a1, CYP27b1, and CYP24a (rats with strokes) – May 2024 Genetics Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024 Vitamin D response varies from resistance that increases through life to hypersensitivity – May 2024 Rickets is typically due to little Vitamin D getting the cells - April 2024 Autoimmune diseases and poor Vitamin D genes – GC, CYP2R1, CYP27B1, and VDR – April 2024 Cancers are sometimes associated with poor CYP24A1 gene (Vitamin D) (Bladder Cancer in this case) – April 2024 SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024 Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024 Microencapsulated Vitamin D better than oil-based in 6 ways – Sept 2023 Gestational Diabetes and Vitamin D - many studies VitaminDWiki Mega-Search (Interim Version) CYP27B1 DNA and VDR tests - 120 to 200 dollars Brain and Vitamin D - many studies Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics) COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021 Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 Boron appears to increase Vitamin D by inhibiting a gene - 2004 Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022 Many reasons why vitamin D deficiency has become epidemic Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016 Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022 CYP2R1 gene reduces response to Vitamin D - many studies Overview Parkinson's and Vitamin D Vitamin D genes – Review June 2022 Many genes can restrict Vitamin D from getting to the cells – Aug 2023 Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023 Topical Vitamin D 1 in 10 have Chronic Kidney Disease (but only 5% are aware of it) – review Sept 2019 MegaSearchOverview Vitamin D is associated with 6 genes, 7 receptors, and a new book - Oct 2023 Vitamin D and it’s related genes regulate the immune system – Aug 2023 Telomeres in boys were 2.5% longer if 9 ng higher vitamin D – July 2018 Telomeres (which extend life) appear to be extended by Vitamin D - March 2015 Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022 Vitamin D activation is mainly done by the tissues, not the Liver and Kidneys 12 Vitamin D genes (Most are not noticed by blood test) – Sept 2021 Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021 Vitamin D Health problems can run in families (epigenetics, they miss other reasons) – June 2023) Off Topic: DNA data finally being used to identify diseases caused by genes- June 2023 Oral cancers might be prevented and treated by Vitamin D (VDR may be important) – Review May 2023 Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 Cystic Fibrosis appears associated with poor Vitamin D genes (radioactive tracing) – May 2023 Vitamin D - A master example of nutrigenomics – April 2023 Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1) – Oct 2021 Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023 Response to a large dose of vitamin D (80,000 IU) typically varied by 2 X – June 2016 Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023 No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023 Poor CYP2R1 gene reduces blood response to Vitamin D supplementation – Aug 2019 Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020 Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021 Vitamin D dosing varies with genes, PTH, Mg, Vit K, etc – video and transcript Sept 2022 Vitamin D resistant genes (CYP24A1, SMRT, SNAIL) – July 2022 Vitamin D Myths - OTHER Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022 Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019 Vitamin D actions which are faster than gene interactions – March 2016 Study incorrectly implies that genes that restrict cellular Vitamin D are not associated with COVID – Nov 2022 Vitamin D daily - Evolution: 4,000 IU, Government: 800 IU– Veith Oct 2022 Thyroid Cancer 1.9 X more likely if poor gene to generate Vitamin D from the sun (DHCR7) – July 2019 Many Vitamin D similarities: people and cows - March 2022 Neuro problems (AD, PD, MSA) associated with poor vitamin D genes (CYP27A1, CYP27B1) – Sept 2022 Ignoring dose size etc, meta-analysis concludes that Vitamin D does not help (stroke risk in this case) – Aug 2022 Overview of VitaminDWiki Increased occurrence of Graves' and Hashimoto's diseases if poor Vitamin D genes – Nov 2014 Why many vitamin D trials fail to find benefits - Nov 2016 Some diseases reduce vitamin D getting to blood or cells An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes – June 2022 Some COVID hospitalizations are due to poor Vitamin D genes (Binding Protein in this commentary) – June 2022 Fertility is a function of vitamin D around each egg (follicular fluid) – many studies Vitamin D metabolism and genes as of Nov 2019 Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor – March 2022 Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016 Vitamin D Binding Protein may affect immune system dendritic cells – March 2022 Breast Cancer, Vitamin D, and genes – Welsh Nov 2021 Vitamin D and COVID - Davies, Benskin (Dark Horse video with transcript) - Dec 27, 2021 Lower vitamin D associated with several new genes (Korea GWAS) – Dec 2021 Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020 COVID-19 cytokine storms perhaps better stopped by the CYP11A1 Vitamin D pathway – Aug 11, 2020 Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D) – Dec 2017 Fully-activated Vitamin D (Calcitriol) is produced inside and outside of the kidneys – July 2020 Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021 CYP2R1 (vitamin D 25-hydroxylase ) semiactivates vitamin D in many places in the body COVID-19 5X worse if poor Vitamin D gene (CYP2R1) – June 2021 Vitamin D testing accuracies, including dried blood spot – Jan 2020 Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018 Parathyroid increase with age associated with worsening Vitamin D genes – April 2020 Cytomegalovirus downregulates Vitamin D receptor, but tissues respond by increasing production – Sept 2016 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016 430 genes changed when 3,800 IU Vitamin D added in late second trimester – RCT May 2018 291 genes improved expression by 2000 IU of vitamin D – RCT March 2013 Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021 Zika birth defects may be prevented by Vitamin D – May 2016 Why Mendelian randomization fails with Vitamin D – March 2021 DHCR7 enzyme (gene) synthesizes cholesterol or vitamin D (when UVB is available) – Sept 2016 Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021 Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019 Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020 Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016 Do not expect your doctor to know about vitamin D Low Vitamin D in blood is associated with 69 genes, only 6 of which are reported on - Feb 2020 Response to Vitamin D varied by 12 ng due to gene variants (CYP2R1) – Aug 2019 Vitamin D effects on over 300 genes varies with genetics and levels – Dec 2020 Increased Colorectal cancer risk if Vitamin D does not lower PTH (Vit D not getting to cells) – Nov 2020 Glucocorticoid treatment reduces Vitamin D getting to cells via 3 or 4 genes Diabetes changes liver genes so as to destroy (catabolize) Vitamin D – May 2016 Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017 Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017 Vitamin D roles in obesity: genetics and cell signaling – June 2013 Genes indicate that Obesity causes vitamin D deficiency – Feb 2013 Some Rickets is due to poor genes - Vitamin D needed lifelong – June 2020 Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019 CYP2R1 mutations also cause vitamin D-deficient rickets – July 2016 COVID-19 is strongly associated with low vitamin D Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem) – Aug 2018 Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017 Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020 Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020 Race changes the risk of various health problems, but many questions remain – Sept 2018 Most Autism Risk factors are associated with low vitamin D - March 2014 Gene problem discovered by taking Vitamin D, sibling had same gene problem – Dec 2019 CYP2R1 and GC variations decrease vitamin D response – PHD thesis Nov 2015 Strong Vitamin D deficiency associations in Asthma patients – Nov 2014 Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017 Benefits of Vitamin D often limited by genes Live longer if have more than 40 ng of Vitamin D (gene analysis of 10,500 people) – Jan 2019 Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 Antibiotics and Vitamin D are associated with many of the same diseases How to read a medical study (with notes on Vitamin D studies) – Oct 2019 Vitamin D Binding Protein Review - Oct 2019 Vitamin D Receptor summary Hypothesis - Vitamin D is also activated, stored, and degraded in tissues (autacoid) – Sept 2019 Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014 Infertility is also associated with poor Vitamin D Binding Protein – Oct 2017 Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 Genes which regulate active vitamin D worsen with age – Oct 2016 Review of 11 Vitamin D genes – Nov 2017 Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017 Body may change gene activation if more Vitamin D is needed (Schizophrenia in this case) – Oct 2018 Lung cancer – reduced deaths if have a good vitamin D gene (CYP27B1) – Feb 2015 ALS associated with poor CYP27B1 gene (not seen by Vitamin D blood test) – May 2019 Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019 Type II diabetes 2 X more likely if poor Vitamin D Gene (CYP27B1) – Oct 2019 Less Vitamin D available to tissues U.S. healthcare system (and its investors) are really good at monetizing illness, but not wellness – May 2019 Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks – May 2019 Genes evolve to adapt to excess or low vitamin D (Eskimo, Reindeer, etc.) – June 2019 Obesity cut semi-activation of Vitamin D in half (mice) – Jan 2019 Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019 Drug hypersensitivity is associated with Vitamin D Binding Protein, etc. – June 2019 Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014 Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019 Less vitamin D generated from sunlight by schizophrenia patients – 2016 Ulcerative Colitis (new) associated with lower free and bioavailable Vitamin D, but not total – Feb 2019 Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018 Poor Vitamin D binding had 30 percent less response to Vitamin D (50,000 IU weekly) – Feb 2019 Vitamin D reduced so low that Victorian age diseases are returning Vitamin D insufficiency was 3.7 X more likely if CYP2R1 gene variation– June 2014 Vitamin D clinical trials should be based on Vitamin D tests – Aug 2017 Vitamin D Heritability: twin studies – 20 percent to 85 percent, GWAS 5 percent – Oct 2018 Many health risks associated with low Vit D or poor Vitamin D Receptor – more RCT needed – March 2018 Kidney failure 1.7X more likely - Vitamin D Binding Protein – Feb 2016 Low frequency hearing loss (Otosclerosis) associated with vitamin D genes– April 2013 Vitamin D affects at least 3,023 DNA locations – July 2018 Sore mouth due to cancer therapy (oral mucositis) substantially reduced by daily 1,000 IU of vitamin D – June 2017 Breast Cancer far more likely in the sister having poor Vitamin D binding protein or poor CYP2R1 gene – March 2018 If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016 Do you have a Vitamin D Receptor Mutation (and might need more vitamin D) – Jan 2018 Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016 Coronary Heart Disease 57 percent more likely if poor Vitamin D Binding Protein with high PTH – Nov 2017 Calcium problems associated with CYP24A1 (a Vitamin D gene) – Oct 2017 Heart Disease 40 percent more likely in women having poor Vitamin D Binding Protein – Sept 2017 Genes and Vitamin D – literature review – Dec 2015 Common Vitamin D gene variants and resulting diseases – Jan 2013 More than 5X increase in activation of scores of genes for women with Vitamin D (20,000 IU weekly) RCT Oct 2017 Response to 1000 IU of vitamin D varies by about 4 percent due to gene variants – RCT July 2014 Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review Jan 2016 Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015 Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 Inflammatory blood markers (CRP, white blood cells) vary with Vitamin D level– Jan 2017 Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016 Many US kids have less than 40 ng of Vitamin D – 99 out of 100 blacks, 91 out of 100 whites – Jan 2017 Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017 Vitamin D dose size needed – VitD testing tells only a portion of the story – Jan 2016 2,776 vitamin D receptor binding sites - April 2014 How should Vitamin D be tested – a changing landscape – June 2016 Vitamin D interactions inside of the cell - May 2016 Genes May Play a Role in Vitamin D Deficiency – June 2010 All pregnant women (in UK) should have free vitamin D – Gillie Aug 2015 Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 CYP2R1 gene probably responsible for low vitamin D response – RCT April 2014 Genes in the blood are not static, 20 percent change with the seasons - such as Vitamin D Receptor – May 2015 Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc. Increased mortality associated with low vitamin D genes – Nov 2014 New approaches to bones, genes, and vitamin D – Jan 2014 VitaminDWiki News for Feb and March 2013 Vitamin D gene expression associated with diseases – March 2013

Many reasons for the decrease in Vitamin D getting to blood and cells

The following chart triggered the creation of the chart at the top of this page

Articles in both Pregnancy and Genetics:

Articles in both Multiple Sclerosis and Genetics

Genes on the web

Attached files

Health Problems and D

Genetics

Many reasons for the decrease in Vitamin D getting to blood and cells

The following chart triggered the creation of the chart at the top of this page

Articles in both Pregnancy and Genetics:

Articles in both Multiple Sclerosis and Genetics

Genes on the web

Backlinks

Page actions

Attached files

Health Problems and D