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Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017

Vitamin D receptor gene FokI polymorphism in Egyptian children and adolescents with SLE: A case-control study.

Lupus. 2017 Jan 1:961203317725588. doi: 10.1177/0961203317725588. [Epub ahead of print]
Imam AA1, Ibrahim HE2, Farghaly MAA3, Alkholy UM2, Gawish HH4, Abdalmonem N2, Sherif AM5, Ali YF2, Hamed ME2, Waked NM6, Fathy MM2, Khalil AM2, Noah MA2, Hegab MS2, Ibrahim BR2, Nabil RM4, Fattah LA7.


Vitamin D Receptor category has the following

Genetics category listing contains the following

The first chart on this page untill Oct 2017 had been

The following chart triggered the creation of the chart at the top of this page


Note the assumption, which may be correct, that the immune system only responds to tissue Vitamin D, rather than from blood vitamin D

Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 has the following chart
Genes and vitamin D  page 6748
All articles in both Pregnancy and Genetics:

Here are all 209 articles

Note: a software bug includes items from the subcategories of Vit D Receptor and Vit D Binding protein - sometimes 3 entries total

See also Vitamin D Binding Protein category listing has 83 items

In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
    No such attachment on this page
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."


Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
Short URL = is.gd/VitDReceptor

Background Childhood-onset systemic lupus erythematosus (cSLE) is a lifelong autoimmune disorder. The vitamin D receptor (VDR) gene is a potential candidate gene for cSLE susceptibility.

In this study, we aimed to investigate the FokI polymorphism in the VDR gene in Egyptian children and adolescents with SLE, to determine whether this polymorphism could be a genetic marker for cSLE susceptibility or disease activity and we also measured the serum level of 25-hydroxyvitamin D [25(OH) D] to assess its relation to such polymorphism.

Methods This was a case-control study, which included 300 patients with cSLE and 300 age, sex, and ethnicity-matched healthy controls. All participants were genotyped for the VDR gene FokI (rs2228570) polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while the serum [25(OH) D] levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results The VDR FokI FF genotype and F allele were overrepresented among cSLE patients compared with the controls, [odds ratio (OR) = 2.7; 95% confidence interval (CI): 1.6-4.4 for the FF genotype; p = 0.000; and OR = 1.6; 95% CI: 1.27-2.05 for the F allele; p = 0.000, respectively].
We found a significant association between VDR FokI FF genotype with lupus nephritis (OR: 4.8; 95% CI: 2.2-10.6; p = 0.002); and high disease activity index score ( p = 0.01).

Conclusions The FokI polymorphism in the VDR gene may contribute to susceptibility to SLE in Egyptian children and adolescents. Moreover, the FF genotype constituted a risk factor for the development of lupus nephritis and was associated with low serum [25(OH) D] levels as well as higher disease activity index score among studied patients with cSLE.

PMID: 28799838 DOI: 10.1177/0961203317725588


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