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Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019

Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth

BMC Pregnancy and Childbirth volume 20, Article number: 3 (2019)

VitaminDWiki

Items in both categories Pregnancy and Vitamin D Receptor are listed here:


Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

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Letícia Veríssimo Dutra, Fernando Alves Affonso-Kaufman, Fernanda Ramires Cafeo, Milene Saori Kassai, Caio Parente Barbosa, Francisco Winter Santos Figueiredo, Fabíola Isabel Suano-Souza & Bianca Bianco

Background
Premature birth is the main cause of mortality in children under 1 year, and vitamin D deficiency during gestation is associated with prematurity. The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene. VDR variants—such as single nucleotide variation (SNV)—are associated with increased risk of prematurity, but there are conflicting results. We evaluated serum vitamin D concentrations and the frequency of TaqI/A > G, BsmI/C > T, ApaI/C > A, and FokI/A > T VDR variants in mothers and preterm (PTN) and full-term (FTN) newborns.

Methods
We conducted a case-control study comprising 40 pairs of mothers and their PTNs (gestational age < 32 weeks and/or weight < 1500 g), and 92 pairs of mothers and FTNs as controls. Genotyping was performed by real-time PCR, and plasma vitamin D concentrations were measured by electrochemiluminescence.

Results
Vitamin D levels were significantly lower in PTN mothers. Genotypes TaqI/GG and BsmI/TT, and haplotypes AAG (TaqI/A-ApaI/A-FokI/G) and GCA (TaqI/G-ApaI/C-FokI/A) were significantly more frequent in PTN mothers, and genotypes TaqI/AG, ApaI/AA, and FokI/AG resulted in significantly lower vitamin D levels. Genotypes BsmI/TT and ApaI/AA were associated with vitamin D deficiency and 2.36 and 7.99 times greater likelihood of PTB, respectively. Vitamin D levels were also lower in PTNs, although it was not statistically significant. Genotypes BsmI/TT, ApaI/AA, and FokI/GG, and haplotype GAG (TaqI/G-ApaI/A-FokI/G) were significantly more frequent in PTNs. Those with FokI/GG genotypes had significantly lower vitamin D levels.

Conclusions: VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity.

Created by admin. Last Modification: Tuesday December 31, 2019 20:14:18 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
13268 Preterm T4.jpg admin 31 Dec, 2019 20:08 125.81 Kb 47
13266 Preterm VDR.pdf PDF 2019 admin 31 Dec, 2019 20:08 376.56 Kb 28
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