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Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023

Vitamin D deficiency and genetic polymorphisms of Vitamin D-associated genes in Parkinson’s Disease

European Journal of Neuroscience preprint DOI: 10.22541/au.167407862.25881100/v1
Barnali Ray Basu1, Randrita Pal1, Supriyo Choudhury2, Hrishikesh Kumar2, Sanjit Dey3, and Nilansu Das1
1Surendranath College
2Institute of Neurosciences Kolkata
3University of Calcutta Faculty Council for Post-Graduate Studies in Science


Parkinson’s Disease (PD) and vitamin D share a unique link as Vitamin D deficiency (VDD) prevails in PD. Thus, an in-depth understanding of Vitamin D biology in PD might be crucial for therapeutic strategies emphasizing Vitamin D. Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D-associated genes in PD, like

  • VDR (Vitamin D Receptor) or
  • GC (Vitamin D Binding Protein),

may aid the process along with polymorphisms of Vitamin D metabolizing genes (e.g., CYP2R1, CYP27A1) in PD. Literature review of single nucleotide polymorphisms (SNPs) related to Vitamin D levels [GC (GC1- rs7041, GC2-rs4588), CYP2R1, CYP24A1, CYP27B1] and Vitamin D function [VDR (FokI - rs2228570, Apal - rs7976091, BsmI-rs1544410, TaqI-rs731236)] was conducted to explore their relationship with PD severity globally. Furthermore, the DisGeNET database was utilized to explore the gene-disease associations in PD, and STRING alongside Cytoscape was utilized to identify critical genes associated with PD. VDR-FokI polymorphism was reported to be significantly associated with PD in Hungarian, Chinese, and Japanese populations, whereas VDR-ApaI polymorphism was found to affect PD in the Iranian population.
However, VDR-TaqI and BsmI polymorphisms had no significant association with PD severity.
Conversely, GC1 polymorphisms reportedly affected Vitamin D levels without influencing the disease severity.
CYP2R1 (excluding rs1993116) was also reportedly linked to clinical manifestations of PD.
Genetic polymorphisms might cause VDD despite enough sunlight exposure and vitamin D-rich food intake, enhancing inflammation, and thereby influencing PD pathophysiology.
Knowledge of the polymorphisms associated with vitamin D appears promising for developing new therapeutic strategies against PD.
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VitaminDWiki - Overview Parkinson's and Vitamin D contains

VitaminDWiki - 5 studies in both categories Parkinson's and Genetics

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VitaminDWiki - 11 studies in both categories Parkinson's and Vitamin D Receptor

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VitaminDWiki – CYP27B1 category contains

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
Poor CYP27B1 is assocated with COVID, Miscarriage,   Lupus,   Alz, Parkinson, MSA,   Rickets

CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

What can be done if have a poor CYP27B1

  • Larger doses of Vitamin D
  • More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
  • Additional sources: UV
  • Increase Vitamin D metabolism: additional Magnesium, Omega-3
    • All cytochrome P450 enzymes require Mg++ as a cofactor
  • Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR

Vitamin D blood test misses CYP27B1 and other genes
in Visio for 2023

VitaminDWiki – Cancers might alter CYP24A1 gene

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Items found: 10

VitaminDWiki – Vitamin D Binding Protein category listing has 177 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,

VitaminDWiki – Vitamin D Binding Protein has a list of health problems

Health Problem
11 XPreeclampsia
6.5XT1D in SA Blacks
6 XFood Allergy
4 X, 5XKidney Cancer
4 XPoor Response to Oral Vitamin D
3 XEar infection
2.8 X MS
2 X Colorectal Cancer
2 XProstate Cancer -in those with dark skins
1.3 XInfertility

Attached files

ID Name Comment Uploaded Size Downloads
19216 D and PD.jpg admin 14 Feb, 2023 117.98 Kb 268
19215 PD genetics.pdf admin 14 Feb, 2023 286.58 Kb 139