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Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer’s Disease: A Mendelian Randomization Study

Nutrients 2018, 10(9), 1243; https://doi.org/10.3390/nu10091243
Susanna C. Larsson 1,,Matthew Traylor 2, Hugh S. Markus 2 and Karl Michaëlsson 3

Information on Genes in VitaminDWiki

Gene# of pages
Oct 2017
CYP27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein
3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess

Alzheimer's strongly associated with 2 genes and weakly associated with 5 others

Genetics category listing contains the following

266 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

Alzheimers-Cognition - Overview starts with

Studies in both categories Cognition and Vitamin D Receptor

 Download the PDF from VitaminDWiki

We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer’s disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables.

Data for AD were acquired from the International Genomics of Alzheimer’s Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97–1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78–0.94; p = 0.002).
This study provides evidence that vitamin D may play a role in AD but
   found no significant association between S-PTH and AD.

Created by admin. Last Modification: Tuesday December 10, 2019 14:13:04 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
11887 Alz Genes.jpg admin 01 May, 2019 20:47 44.72 Kb 319
11886 194-Alzheiemr's disease vit D, PTH Mendelian Larsson.pdf PDF 2018 admin 01 May, 2019 20:47 1.04 Mb 208
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