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Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis Sept 2021

Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Cureus 13(9): e17883. doi:10.7759/cureus.17883
Sunam Kafle, Anjan Kumar Basnet, Kumar Karki, Manusha Thapa Magar, Shumneva Shrestha, Randhir S. Yadav
Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is a significant public health issue, especially in developing countries, affecting millions of people every year. Despite the development of many antitubercular antibiotics and increased awareness of preventive methods, it is still a major cause of mortality worldwide. Vitamin D, a micronutrient known to have a major role in bone and calcium metabolism, has also shown its immunomodulatory effects to suppress mycobacterial growth. We conducted a systematic review and meta-analysis of the available evidence to explore the association between vitamin D levels and tuberculosis. We performed a systematic search for articles from inception to May 2021 in multiple databases.

We included 26 studies in our qualitative synthesis and 12 studies in meta-analysis or quantitative synthesis. In our meta-analysis, we used a random-effect model to calculate the odds ratio (OR) of vitamin D deficiency in tuberculosis patients compared to the healthy controls. On pooled analysis, we found that the odds of the participants having vitamin D deficiency was 3.23 times more in tuberculosis patients compared to the healthy group (OR=3.23, CI = 1.91-5.45, p<0.0001). Thus, we concluded that there is an association between low levels of vitamin D and tuberculosis infections. We suggest conducting long-term prospective cohort studies in tuberculosis endemic countries to better understand the causal relationship between vitamin D deficiency and tuberculosis.
 Download the PDF from VitaminDWiki

Overview Tuberculosis and Vitamin D has the following summary

Many studies have found that Vitamin D both PREVENTS and TREATS TB

TB and vitamin D 121 items

A few vitamin D and TB in VitaminDwiki

TB Meta-analysis

A Poor Vitamin D Receptor prevents Vitamin D in blood from getting to the cells

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by:

(Resveratrol)),  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc

TB and Vitamin D Receptor:

Created by admin. Last Modification: Wednesday October 20, 2021 16:04:18 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
16456 TB Meta.jpg admin 20 Oct, 2021 28.89 Kb 225
16455 TB 13th meta.pdf admin 20 Oct, 2021 459.46 Kb 257