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Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021

Association between Gene Polymorphisms of Vitamin D Receptor and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis - Jan 2021

Int. J. Environ. Res. Public Health 2021, 18(1), 205; https://doi.org/10.3390/ijerph18010205
by Qian Zhou 1,2,Shiwu Wen 3,4,Miao Liu 1,2,Sulei Zhang 1,2,Xin Jin 5 and Aizhong Liu 1,2,*

Background: Studies on the association between Vitamin D receptor gene polymorphism and gestational diabetes mellitus have been inconsistent. The aim of this study was to summarize available evidence on the association between polymorphisms of Vitamin D receptor genes and susceptibility to gestational diabetes mellitus.

Methods: We searched databases of PubMed, Web of Science, Embase, China national knowledge infrastructure (CNKI), China science and technology journal database (VIP), and Wanfang Data for relevant articles. A systematic review and a meta-analysis were done to compare the distribution of Vitamin D receptor gene polymorphisms in gestational diabetes mellitus patients with those in controls using allelic, codominant, dominant, and recessive models.

Results: A total of eight eligible articles were included in the systematic review and of them, six articles were included in the meta-analysis. The vitamin D receptor gene rs7975232 polymorphism was associated with gestational diabetes mellitus under the allelic model (odds ratio = 1.28, 95% confidence interval 1.06–1.56), codominant model (CC vs. AA odds ratio = 1.97, 95% confidence interval 1.28–3.05), and recessive model (odds ratio = 1.83, 95% confidence interval 1.27–2.64) in the case of low heterogeneity. High heterogeneity existed in studies on the association of vitamin D receptor genes rs1544410, rs2228570, and rs731236 with gestational diabetes mellitus, and the most common sources of heterogeneity were the year of publication and matching.

Conclusion: Polymorphism of the vitamin D receptor gene rs7975232 may be associated with risk of developing gestational diabetes mellitus. Future studies should be designed to include standardized data collection and matching for important confounding factors such as body mass index, age, and race.
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The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis - Dec 2021

Diabetol Metab Syndr . 2021 Dec 13;13(1):144. doi: 10.1186/s13098-021-00764-y.
Sai Liu 1

Background: Gestational diabetes mellitus (GDM) is a common disease during pregnancy. The association of vitamin D receptor (VDR) polymorphisms with GDM is still controversial. This study aimed to assess the associations between VDR polymorphisms and GDM risk.

Methods: We searched Cochrane Library, PubMed, and Embase electronic database for all eligible studies published from Jan 1, 1980 to December 31, 2020 to conduct a Meta-analysis. We analyzed four VDR polymorphisms: BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), and FokI (rs2228570).

Inclusion criteria: (1) The data can be evaluated; (2) case-control study; and (3) meeting the Hardy-Weinberg's law.

Exclusion criteria: (1) Insufficient or extractable data; (2) Severe publication bias in the data; and (3) duplicate publications. We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls.

Results: We eventually included 15 studies in seven articles, including 2207 cases and 2706 controls. The data showed that ApaI (rs7975232) VDR gene polymorphism was related with the risk of GDM for the comparison of CC vs AA and recessive model in overall population and FokI (rs2228570) VDR gene polymorphism was associated with the risk of GDM for recessive model in overall population. BsmI (rs1544410) polymorphism was not related with the risk of GDM in overall population. However, in the analysis of subgroups grouped by race, BsmI (rs1544410) has certain correlations. And, the data suggested the TaqI (rs731236) polymorphism was not associated with GDM.

Conclusion: Based on the meta-analysis, VDR ApaI (rs7975232) and FokI (rs2228570) polymorphisms increase susceptibility to GDM. In the future, it can be used to diagnose and screen molecular biomarkers for GDM patients.
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VitaminDWiki - VDR

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

VitaminDWiki - Pregnancy and VDR and Diabetes

VitaminDWiki - Pregnancy and VDR

VitaminDWiki - Diabetes and VDR

VitaminDWiki with GESTATIONAL DIABETES in title (36 as of July 2022)

This list is automatically updated

Items found: 38
Title Modified
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 17 Jul, 2023
50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015 12 Jul, 2023
Poor placental Vitamin D genes associated with gestational diabetes and preeclampsia - April 2023 01 May, 2023
Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022 07 Aug, 2022
Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022 14 Jul, 2022
Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021 14 Jul, 2022
Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 31 May, 2022
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 25 Jul, 2020
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018 14 Jun, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012 23 Mar, 2019
Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019 23 Mar, 2019
Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018 17 Mar, 2018
Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015 07 Feb, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007 30 Dec, 2017
Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017 15 Dec, 2017
Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017 15 Dec, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 09 Nov, 2017
Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017 04 Oct, 2017
Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016 07 Jun, 2017
Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016 04 Jan, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014 09 Apr, 2016
Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016 16 Jan, 2016
Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015 13 Jan, 2016
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015 01 Jul, 2015
Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014 14 Apr, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013 31 Aug, 2013
Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012 15 Nov, 2012

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Attached files

ID Name Comment Uploaded Size Downloads
16746 VDR getational Diabetes.pdf admin 14 Dec, 2021 13:18 2.05 Mb 219
14785 ijerph-18-00205.pdf PDF 2021 admin 29 Dec, 2020 20:56 1.02 Mb 419