The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Randomized controlled trials have proven that many of the causes of death are prevented and/or treated by Vitamin D
Proof that Vitamin D Works has the following list
ADHD, Alcoholic Liver Cirrhosis, ALS, Alzheimer's, Antibiotic Use in Seniors, Asthma, Autism, Autoimmune Diseases, Back pain, Blood Cell Cancer, Breast Cancer, Cardiovascular, Cholesterol, Chronic Hives, Chronic Kidney Disease, Cluster Headaches, Congestive Heart Failure (Infants), COPD, Crohn's Disease, C-Section and Pregnancy Risks, Cystic Fibrosis, Depression, Diabetes, Diabetic Neuropathy, Eczema, Falls, Fatigue, Fatty Liver (Child), Fibromyalgia, Gestational Diabetes, Gingivitis, Growing Pains, Hay Fever, Heart Attack, Hemodialysis, Hepatitis-C, Hip Fractures, Hypertension, Influenza, Irritable Bowel Syndrome, Ischemic Stroke, Knee Osteoarthritis, Leg Ulcers, Low Birth Weight, Lupus, Male Infertility, Menstrual Pain, Metabolic Syndrome, Middle Ear Infection (Infants), Mite Allergy, Multiple Sclerosis, Non-Alcoholic Fatty Liver Disease, Osteoarthritis, Parkinson's Disease, Perinatal Depression, Pneumonia (Ventilator-associated), Poor Sleep, PreDiabetes, Preeclampsia, Pre-term Birth, Prostate Cancer, Quality of Life, Raynaud's Pain, Respiratory Tract Infection, Restless Leg Syndrome, Rheumatoid Arthritis, Rickets, Sarcopenia, Sepsis, Short Neonates, Sickle Cell, Stronger Senior Muscles, Survive ICU, TB, Tonsillitis, Trauma Death, Traumatic Brain Injury, Tuberculosis, Ulcerative Colitis, Urinary Tract Infection, Vaginosis, Vertigo, Warts, Weight Loss
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Click on underlined items for details
Health Problem | Treat Prevent | Reduction by Vit D | RCT = Randomized Controlled Trial * = link to additional RCT CT = Clinical Trial |
Hypertension | T P | 149 to 142 mm Hg HT risk reduced 10X | RCT* *, 2400 IU. 100,000 IU* When Vitamin D > 40 ng |
Cardiovascular after attack | T | 32 % fewer deaths | CT 1000 IU |
Diabetes Type 1 | P | 85 % | 12,000 kids, 2000 IU |
Diabetes Type 2 | T | 62 % | RCT* CRP reduction, 4000 IU Injection is far better - RCT * RCT 50,000 IU/2weeks + probiotics RCT 5,000 IU daily 6 months |
Back Pain | T | 95 % reduced 50% | 5000/10000 IU 60,000 IU weekly |
Influenza | P | 90 % | RCT *, 2000 IU |
Falls | P | 50% | RCT, 100,000 IU monthly RCT with Meals on Wheels 2016 |
Hip Fractures | P | 30 % | RCT * 800 IU |
Rickets | P | 98 % | Turkey, 400 IU NOT RCT, given to all children |
Raynaud's Syndrome | T | 40 % | RCT, visual scale, 20000 IU Avg |
Menstrual pain | P | 76 % | RCT, 7000 IU Avg, 70% reduction 2018 PMS reduced by half |
Pregnancy risks | P | 50 % | RCT, 4000 IU |
C-section, unplanned | P | 50 % | RCT, 4000 IU, small study |
Low birth weight | P | 60 % | RCT * 1000 IU of D2 |
TB | P | 60 % | RCT, 800 IU |
Breast Cancer | P | 60 % | RCT, 1100 IU (2007) |
Rheumatoid Arthritis pain | T | 40 % | RCT, 500 IU, added to prescription |
Cystic Fibrosis | T | 75 % 2nd study improved | RCT, pilot 4X fewer deaths 250,000 IU RCT, pilot 8,200 IU |
Chronic Kidney | T | 90 to 70 PTH | RCT, 3500 IU, |
Respiratory Tract Infection | P | 63 % | 3 RCT, 4000 IU 1 year 2nd 2000/800 IU 20,000 IU weekly |
Lupus | T T | zero flares Pain reduced | Loading then 100,000 IU monthly, RCT too RCT 4,000 IU |
Sickle Cell | T | Less pain | RCT, up to 100,000 IU/week |
Leg ulcer healing | T | 4X faster | RCT, 50,0000 IU/week, small study |
Traumatic Brain Injury | T | 2X | RCT, 20,0000 IU/day with progesterone |
Parkinson's Disease | T | Stabilized | RCT, 1200 IU/day |
Multiple Sclerosis | P T | 68% 95% were CURED | RCT, 7100 IU prevent pre-MS ==> MS 20,000 to 140,000 IU/day |
Congestive Heart Failure | T | 90 % | RCT, 1000 IU infants (also: Adults, not RCT) |
Middle Ear Infection | P | 30 % | RCT, 1000 IU infants |
Gingivitis | T | 88 % | RCT, 2000 IU |
Muscle in seniors | T | 17 % more muscle | RCT, 4000 IU |
Antibiotic use when >70y | T | 47 % | RCT, 60,000 IU monthly |
Infants taller | Benefit | 1 cm tall | RCT, 50,000 IU weekly, for 8 weeks while pregnant |
Gestational Diabetes | T | Reduced 3X | RCT, 2 doses of 50,000 IU |
After Heart Attack | T | +6% ejection fraction | RCT, 800,000 IU one time |
Prostate Cancer | T | Fewer +cores | RCT, 4000 IU (2012) |
Asthma | P T | Reduced symptoms | RCT, 60K IU/month; RCT 50K IU/week Need good D at 4 weeks into preg. |
Depression | T | Reduced | RCT 300,000 IU injection RCT 1500 IU helped Prozac RCT 50,000 IU weekly, elderly |
Low vitamin D while breastfed | P | All infants > 20 mg | RCT, 5,000 IU |
Fibromyalgia | T | Half of many still has Fibro | RCT, 30-48 ng RCT 50K IU/week |
Hives, Chronic | T | Reduced 40% | RCT, 4000 IU added |
Cholesterol | T | Reduced 4 mg | RCT, 400 IU + Ca |
Weight Loss | T | lost 5 more lbs | RCT, 2000 IU +diet +exercise |
Gestational Diabetes | P | 40% | RCT * , 5,000 IU |
Chronic Obstructive Pulmonary Disease | T | 17X improvement | CT, 50,000 IU weekly RCT 100,000 IU monthly |
Asthma | T | 1/2 Asthma attacks | RCT >42 mg of vitamin D |
Quality of Life (QoL) | T | Nursing Home QoL | CT, 4,000 IU in daily bread |
Death of Critically Ill Patients | T | 20% increase in survivability | RCT 540 K IU loading than 90K monthly |
Restless Leg Syndrome | T | Score 26 ==> 10 | CT, Vitamin D dose size not stated in abstract |
Hepatitis-C | T | Aided normal drugs | RCT 2.000 IU |
Crohn's disease | T | improved when > 30 ng 2nd study fewer relapses | RCT 2,000 IU 10,000 IU RCT |
Pre-term birth | P | 2.5X decrease, also: fewer c-section & better Apgar | RCT 2,000 IU India |
Cluster headaches | T | CH eliminated in 60% | 10,000 IU, Mg, Omega-3, etc |
Autism | T | 80% improved | CT 300 IU/kg/day for 3 months |
PreDiabetes | T | ~20% reduced | RCT 60,000 IU/month |
Weight loss: Overweight and Obese | T | 12 lbs in 6 months | RCT 100,000 IU/month |
Sarcopenia = muscle loss | T | 27% increase | RCT 1,000 IU |
Growing Pains | T | 60% decrease | ~100,000 IU/month -NOT RCT 2nd study, similar results |
Osteoarthritis pain | T | 60% decrease | 50,000 IU/weekly - NOT RCT |
ALS | T | helped | 2,000 IU - NOT RCT, given to all |
Vertigo | T | 3X reduction if raised > 10ng | 600,000 IU load, then maint. NOT RCT, given to all |
Warts | T | 80% eliminated injection | NOT RCT 60,000 IU/injection |
Metabolic Syndrome | P | reduced 44% when VitD increased by 30 ng | NOT RCT, given to all |
Hay fever | P | reduced 48% | RCT 1,000 IU for 30 days |
Preeclampsia | P | Recurrance cut in half 3 RCT 3.6 X less likely if > 30 ng | 50,000 IU every 2 weeks 4,000 IU daily |
Blood cell cancer Multiple Myeloma | T | Survival 90% vs 50% | 10,000 IU/week NOT RCT, given to all |
Irritable Bowel Syndrome | T | Reduced | 3,000 IU spray RCT |
Urinary Tract Infection | P | 50% reduction | RCT 20,000 IU weekly |
Mite Allergy | P | 5X reduction | RCT 2,000 IU preg, 800 IU child |
Perinatal depression (depression near birth) | T | 50% reduction | RCT 2,000 IU for just a few weeks |
Vaginosis | T | 10X reduction | RCT 2,000 IU |
Eczema | T | Reduced | 2 RCT 1,600 IU |
Non-Alcoholic Fatty Liver Disease | T | Reduced | RCT 20,000 IU weekly |
Knee Osteoartiritis | T | Pain Reduced | RCT 60,000 IU monthly after loading dose |
Tuberculosis | T | Faster Recovery | RCT single 450,000 IU dose |
Stroke - Ischemic | T | Faster Recovery | RCT single 600,000 IU injection RCT single 300,000 IU injection |
Sepsis | T | Reduce ICU and Hospital length of stay by 7 days each | RCT 400,000 IU |
Trauma deaths | T | 50% fewer deaths | Vitamin D & Glutamine NOT RCT, given to all |
Hemodialysis patients | T | helped | 50,000 IU weekly NOT RCT, given to all |
Fatty liver - child | T | 2 X reduction | RCT Vitamin D & DHA |
Fatigue | T | Reduced | 100,000 IU single dose NOT RCT, given to all |
Sleep Disorders | T | Nicely treated | RCT 50.000 IU bi-weekly |
Pneumonia (Ventilator-associated) | T | RCT Death rate cut in half | 300,000 IU injection |
Infertile males | T | birth rate doubled | RCT 300,000 IU + maint |
Waist size | T | Waist size reduced 3 cm | 100,000 IU loading + maint for 6 months for those with Metabolic Syndrome NOT RCT, given to all |
Attention Deficient Hyperactivity Disorder | T | Reduced Reduced | RCT 3,000 IU for 12 weeks RCT 50,000 IU weekly |
Alcoholic liver cirrhosis | T | improved survival | 1,000 IU of vitamin D NOT RCT |
Diabetic nephropathy | T | Reduced HOMA-IR, FRS | RCT 50,000 IU weekly |
Ulcerative Colitis | T | Reduced 60% | RCT 50,000 IU nano daily for a week |
Obese weight loss | T | Lost 3X more pounds | $10 of Vitamin D added to calorie restriction & walking |
Endometriosis | T | Nicely treated | RCT 50.000 IU bi-weekly |
Diabetic Wounds | T | 4X more likely to heal | RCT 6,400 daily |
Alzheimer's | T | Often reverse | Each person gets a different amount of Vit D, Omega-3, B12, Iron, etc |
Autoimmune | P | Decrease 30% | RCT Vit D + Omega-3 |
Smoking | T | reduce problems | RCT 50,000 bi-weekly |
Tonsillitis | T | Virtually eliminated | RCT 50,000 weekly |
Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets it vitamin D
- 2 are meta-analyses of multiple RCTs
- Vitamin D was given to ALL infants in the entire country (Rickets) - not an RCT
- In several studies, researchers felt that it was unethical not to give vitamin D to everyone
- In some studies, the dose size varied with the needs of the person (overweight, etc)
- In some studies, the COFACTORS were adjusted to the needs of the patients
- Curing requires the dose size and cofactors to be adjusted to the needs of each patient.
Many Clinical Trials have not found a benefit because of one or more of the following failures:
- Fails to use a large enough dose of vitamin D (often < 1,100 IU)
The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D) - Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
- Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
Note: Infrequent dosing also causes unbalancing of the body's chemistry - Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
- Fails to use D3 form, instead uses the less effective D2 form
- Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
Also, differences in Magnesium can result in 30% change in response to vitamin D
Magnesium is dependent on water, food, supplements - Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
- Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
- Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)
Many Meta-Analyses also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
There would be scores of RCT for aspirin not working with 3 mg doses
There would be a many RCT of aspirin not working with 30 mg doses
There would be a few studies of aspirin WORKING with 300+ mg doses
There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
Then there would be a meta-analysis of aspirin and Willow Bark
- That meta-analysis would conclude that aspirin and Willow bark do not work.
While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D
See also VitaminDWiki: Random Controlled Trials with vitamin D intervention
- Intervention - Vitamin D
819 Interventions - Note: It sorts the interventions by health problem as well as by date
- Vitamin D intervention trials - a long list - May 2014 1204 trials
2176 Vitamin D clinical trials as of June 2020: Nutrition Disorders 621, Vitamin D Deficiency 619, Malnutrition 601, Avitaminosis 586, Deficiency Diseases 583, **Metabolic Diseases 489. Musculoskeletal Diseases 362, Bone Diseases 317. Bone Diseases, Metabolic 282, Endocrine System Diseases 241. Osteoporosis 209, Immune System Diseases 190, Kidney Diseases 168, Communicable Diseases 164. Infection 164- Update Jan 2024 2835 Clinical Trials with Vitamin D
- Systematic Reviews or Meta-Analysis of Vitamin D
658 items - 137 health problems associated with low vitamin D – meta-meta-analysis April 2014
- Intervention - 2-30 days
268 items More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + K combined
Vitamin D = 2199, Others = 1803 Vitamin A 702 + Vitamin C 768 + Vitamin K 333 as of Aug 2020
See also VitaminDWiki
- Overview: Vitamin D also TREATS
- Is it ethical to not give vitamin D in osteoporosis trials– NEJM Sept 2010
- Some Vitamin D RCT are not being created because the researchers do not want to deprive the benefits to half of the patients
- Some Vitamin D RCT cannot be started because too many candidates are already taking vitamin D
- Reasons for Vitamin D deficiency
- List of all categories of Vitamin D Information and number of items in each
- List of all Overviews of Vitamin D
74 items along with related searches
CLICK ON chart for more information and translationVitamin D is especially needed during pregnancy
ProblemVit. D
ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Also, The Vitamin D Receptor limits the amount of Vitamin D in the blood actually gets to the tissue
The risk of 48+ diseases at least double with poor Vitamin D Receptor
Short URL = is.gd/dproof
See health problems column of the left of every page in VitaminDWiki for details
Note: There is still no left column in smartphone screens as of July 2024__See also: More vitamin D means fewer deaths – many studies
Top 10 causes of death - low vitamin D is associated with every cause - Nov 20186004 visitors, last modified 26 Jul, 2024, This page is in the following categories (# of items in each category)Attached files
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