Overview Cardiovascular and vitamin D

Cardiovascular category listing has 425 items along with related searches

425 items In Cardiovascular category

• Overview Cardiovascular and vitamin D
• Hypertension and vitamin D
• Overview Metabolic Syndrome and vitamin D
• Overview Stroke and vitamin D
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
• Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
• Heart attack ICU costs cut in half by Vitamin D – Oct 2018

Meta-analyses

• Heart Failure and Vitamin D meta-analyses - 2016, 2019
• Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
• Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018

Omega-3 Helps

• Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
• Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

• Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
• Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016

Cholesterol, Statins

• Cholesterol is needed to produce both Vitamin D and Cortisol
• Overview Cholesterol and vitamin D
• Statins and vitamin D statins often reduce levels of vitamin D
• Statin side-effects are reduced by Vitamin D – US patent Application – April 2019

See also VitaminDWiki: Cardiovascular - general

• Low Vitamin K2 is as risky as smoking for heart disease - Oct 2016
• Yet another heart problem, Cardiac X syndrome, is associated with low vitamin D – 2016
• 800 IU of vitamin D is not enough to help Cardiovascular Disease (found again) – Oct 2016
• Peripheral Arterial Disease 2 percent more likely for every 1 nanogram less Vitamin D – Sept 2016
• Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016
• Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
• Major heart problems avoided if have high vitamin D – 234,000 people Nov 2015
• Cardiovascular Disease and Diabetes helped by Vitamin D – most 2013-15 studies agree
• Cardiovascular Diseases and Vitamin D – Review Feb 2015
• Vitamin D is not a cardiovascular fad like Vitamins C, E, Folic Acid, selenium, beta-caroteen, etc. – Circulation Nov 2013
• More blood was pumped by those getting 800,000 IU of vitamin D after heart failure – RCT Oct 2013
• Sudden cardiac arrest 6X worse outcome if low vitamin D – Nov 2014
• Coronary artery disease extent is associated with extent of vitamin D deficiency – April 2014
• Chronic Heart Failure helped with 2,000 IU of vitamin D (PRA reduced) – RCT June 2013
• 92 percent had low vitamin D before heart surgery– Oct 2014
• Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013
• Major Heart attacks occur 40 percent more often if vitamin D lower than 7 ng – Feb 2013
• Congestive Heart Failure patients helped with Vitamin D intervention – May 2013
• Inflammatory diseases: review of vitamin D, with many tables – May 2014 which has CVD summary tables

Why Cardio Event RCTs are so difficult to design and analyze

Difficulties in Designing Randomised Controlled Trials of Vitamin D Supplementation for Reducing Acute Cardiovascular Events and in the Analysis of Their Outcomes - July 2020
 Download the PDF from VitaminDWiki

See also Vitamin K

See also MORTALITY

All items in Mortality and vitamin D (not just Cardio) 204 items

• Far better to take Vitamin D than a baby aspirin to avoid heart problems

See also HYPERTENSION

• Hypertension and vitamin D Overview
• Heart disease 2.9 X more likely if essential hypertension person has low vitamin D – Jan 2016
• All items in category Hypertension 133 items

Pages listed in BOTH the categories Hypertension and Cardiovascular

See also STROKES

• OVERVIEW of strokes
• All items in category Strokes and Vitamin D 93 items

Items in BOTH of the categories Cardiovascular and Stroke:

See Metabolic Syndrome

Note Metabolic Syndrome = a combination of medical disorders which together increase the risk of developing cardiovascular disease and diabetes.

• Metabolic Syndrome and vitamin D
• All items in category Metabolic Syndrome and Vitamin D 81 items
• Sudden death 6X more likely with Metabolic Syndrome and low vitamin D – March 2012

Items in BOTH of the categories Cardiovascular and Metabolic Syndrome:

See also web

• Cardiovascular benefits of vitamin D - Feb 2014, PDF is attached at the bottom of this page
• Arrhythmias in chronic kidney disease 2011
• Arrhythmias Life Extension date unknown - perhaps 2011
  "Food, drugs, and medications. Coffee, tea, chocolate, red wine, or simply overeating may cause rapid heartbeats that may be frightening when felt but are rarely serious"
  "Both magnesium and potassium are intricately involved in the heart’s electrical stability (Cybulski J et al 2004); consequently, maintaining normal functional blood levels and ratios of each is important"
• More plaque in monkey coronary arteries having less vitamin D receptors April 2012
• Vitamin D status decline during heart surgery linked to bypass machine Vitamin D Council $5 paywall July 2013
  Far less decrease in vitamin D levels in children who did not use the bypass machine.
  Wonder about adults as well
• How does vitamin D help heart health? Vitamin D Council Feb 2014
  Links to previous blogs on Cardiovascular problems and Vitamin D
  Brief review of Renin angiotensin system (RAS); Vascular smooth muscle cells (VSMC); Insulin resistance; Atherosclerosis; Endothelial dysfunction; Cytokines
• Vitamin D deficiency is independently associated with the extent of coronary artery disease May 2014
  Deficiency associated with 30% more CAD risk, especially if Vitamin D < 10 ng
• Cholesterol-Slashing Drug Can Protect High-Risk Heart Patients, Study Finds NYT March 2017
  Cost of $14,523/year. "Number needed to treat" with Repatha appears to be 69
  Number Needed to Treat appears to be 5 - just 800 IU of Vitamin D - for approximately $5 per year
• CVD 2X more prevalent in Korea for those with less than 10 ng of vitamin D May 2012
  6,000 people over the age of 50. Full text on-line

• A National Goal: Prevent a Million Heart Attacks and Strokes by 2022 NYT, Brody, Oct 2018
  Nothing about Vitamin D, lots of the same old solutions - most of which have not and will not work
  Increase exercise, stop smoking, reduce high blood pressure (less salt). reduce high cholesterol (with statins), take a baby aspirin daily

See also web - not Vitamin D

• "Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews" July 2018
   Download the PDF from VitaminDWiki__

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Vitamin D Council on related topics

• Congestive Heart Failure
• Hypertension
• Coronary heart disease

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MAYO Clinic April 2012: Pathways from vitamin D Deficiency to CVD

The effect of vitamin D status on risk factors for cardiovascular disease Nature 2013

$4 to rent the PDF - but the following chart from the study is on Google images

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Random controlled trial found NO HEART FAILURE BENEFIT with 50,000 IU weekly - Feb 2013 - strange

A randomized controlled trial of high dose vitamin D3 in patients with heart failure.
JACC Heart Fail. 2013 Feb;1(1):84-90. doi: 10.1016/j.jchf.2012.11.003.
Boxer RS1, Kenny AM2, Schmotzer BJ3, Vest M4, Fiutem JJ5, Piña IL6.

OBJECTIVE: To investigate the effect of Vitamin D3 on physical performance in patients with HF.

BACKGROUND: HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

METHODS: Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

RESULTS: Patients were age 65.9 ± 10.4 years old, 48% women, 64% African American, EF 37.6±13.9, 36% NYHA III, the remainder NYHA II.
At baseline the vitamin D group 25OHD was 19.1 ± 9.3 ng/ml and increased to 61.7 ± 20.3 ng/ml; in the placebo group baseline 25OHD was 17.8 ± 9.0 ng/ml and decreased to 17.4 ± 9.8 ng/ml at 6 months (between groups p<0.001).
There was no significant change from baseline to 6 months in peak VO2, 6MW, TGUG or isokinetic muscle strength.

CONCLUSIONS: Vitamin D3 did not improve physical performance for patients with HF despite a robust increase in serum 25OHD.
Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation.

PMID: 24614995
 Download the PDF from VitaminDWiki.

Strange - seems like the study did things correctly.Good amount of vitamin D, trial lasted long enough, vitamin D levels were raised high enough. Yet no benefit.

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INTERVENTION Clinical Trials for (heart OR cardiovascular) and "vitamin D" 364 as of Jan 2019

• Intervention = give vitamin D and see what happens usually testing vitamin D vs placebo
• The majority of these intervention trials are for TREATMENT, rather than prevention
• Vitamin D and cardiovascular disease preventiom May 2016
  Large Ongoing Random Controlled CVD trials
  No apparent attempt to trial those with low levels of vitamin D,
  No Magnesium added,
  No Omega-3 added,
  Not much vitamin D used - especially since statins used with CVD reduce the vitamin D
  No Vitamin K2 to stop Calcium increased by Vitamin D from coating the arteries
  

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88 proofs that Vitamin D works (as of Nov 2018)

Proof that Vitamin D Works has the following Cardio related proofs

Health Problem	Treat Prevent	Reduction    click for details	RCT = Random Controlled Trial    * = link to additional RCT CT = Clinical Trial	Vitamin DWiki   #
Hypertension	T	149 to 142 mm Hg	RCT*  *, 2400 IU.  100,000 IU*	1
Cardiovascular after attack	T	32 % fewer deaths	CT 1000 IU	2
Diabetes T2	T	62 %	RCT* *, CRP reduction, 4000 IU	4
Congestive Heart Failure	T	90 %	RCT, 1000 IU infants (also: Adults, not RCT)	27
After Heart Attack	T __	+6% ejection fraction	RCT, 800,000 IU one time	34

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Increased exercise after heart attack cuts in half the chance of death in next four years

• Mercola May 2018
  Back in the 1960's you were supposed to have 6 weeks of bedrest following a heart attack
  Mercola does not mention that exercise might greatly reduce the risk of the heart attack as well

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See also: Omega-3

• Mayo Clinic on methods of dealing with Afib April 2013 at the bottom of this page Includes Vitamin D and Omega-3
• Overview: Omega-3 many benefits include helping vitamin D
• LA Times review of Fish Oil Meta-analysis April 2012
  Clinical studies in recent decades have not shown that taking Fish Oil reduces chance of heart attack
  Wonder - is it perhaps because you need fish oil AND vitamin D, and many people are now have low vitamin D levels?
  CLICK HERE for the meta-analysis study

Items in BOTH of the categories Cardiovascular and Omega-3:

See also Magnesium

Items in BOTH of the categories Cardiovascular and Magnesium:

• See also book on Amazon:Atrial Fibrillation: Remineralize Your Heart Dr. Dean July 2015
  $3. has gotten many 5 star reviews

See also Women

• The #1 killer of women is NOT breast cancer, diabetes or stroke Green Med Info Jan 2019
  1 in 4 women will be diagnosed as having heart disease in thier lifetime

Items in BOTH of the categories Cardiovascular and Women

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