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Overview Cardiovascular and vitamin D

Did you know? (from VitaminDWiki)

Many studies show that cardiovascular problems are treated & prevented by Vitamin D
  As with many other health problems:
  More Vitamin D is needed to treat than to prevent
  Omega-3, Magnesium, and Vitamin K2 also probably also help
      (More Cardiovascular info below this box)
Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing and More in the menu at the top of every page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 249   Diseases that may be related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 248   Colon 139   Lung 54   Prostate 97   Pancreatic 55   Skin 120
Colds and flu   Dark Skin 460   Diabetes 531   Obesity 414   Pregnancy 864   Seniors 407
COVID-19 treated by Vitamin D - studies, reports, videos
499 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

Cholesterol, Statins

See also VitaminDWiki: Cardiovascular - general

Image Image

Why Cardio Event RCTs are so difficult to design and analyze

Difficulties in Designing Randomised Controlled Trials of Vitamin D Supplementation for Reducing Acute Cardiovascular Events and in the Analysis of Their Outcomes - July 2020
 Download the PDF from VitaminDWiki

26 studies in both Cardio and Vitamin K categories

23 studies in both Cardio and MORTALITY categories

All items in Mortality and vitamin D (not just Cardio) 299 items


Pages listed in BOTH Hypertension and Cardiovascular categories (auto updated)

See also STROKES

Items in BOTH of the categories Cardiovascular and Stroke:

See Metabolic Syndrome

Note Metabolic Syndrome = a combination of medical disorders which together increase the risk of developing cardiovascular disease and diabetes.

Items in BOTH of the categories Cardiovascular and Metabolic Syndrome (auto updated):__

See also web


MAYO Clinic April 2012: Pathways from vitamin D Deficiency to CVD

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1422

The effect of vitamin D status on risk factors for cardiovascular disease Nature 2013

$4 to rent the PDF - but the following chart from the study is on Google images

Random controlled trial found NO HEART FAILURE BENEFIT with 50,000 IU weekly - Feb 2013 - strange

A randomized controlled trial of high dose vitamin D3 in patients with heart failure.
JACC Heart Fail. 2013 Feb;1(1):84-90. doi: 10.1016/j.jchf.2012.11.003.
Boxer RS1, Kenny AM2, Schmotzer BJ3, Vest M4, Fiutem JJ5, Piña IL6.

OBJECTIVE: To investigate the effect of Vitamin D3 on physical performance in patients with HF.

BACKGROUND: HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

METHODS: Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

RESULTS: Patients were age 65.9 ± 10.4 years old, 48% women, 64% African American, EF 37.6±13.9, 36% NYHA III, the remainder NYHA II.
At baseline the vitamin D group 25OHD was 19.1 ± 9.3 ng/ml and increased to 61.7 ± 20.3 ng/ml; in the placebo group baseline 25OHD was 17.8 ± 9.0 ng/ml and decreased to 17.4 ± 9.8 ng/ml at 6 months (between groups p<0.001).
There was no significant change from baseline to 6 months in peak VO2, 6MW, TGUG or isokinetic muscle strength.

CONCLUSIONS: Vitamin D3 did not improve physical performance for patients with HF despite a robust increase in serum 25OHD.
Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation.

PMID: 24614995
 Download the PDF from VitaminDWiki.

Strange - seems like the study did things correctly.Good amount of vitamin D, trial lasted long enough, vitamin D levels were raised high enough. Yet no benefit.

INTERVENTION Clinical Trials for (heart OR cardiovascular) and "vitamin D" 312 as of May 2023

  • Intervention = give vitamin D and see what happens usually testing vitamin D vs placebo
  • The majority of these intervention trials are for TREATMENT, rather than prevention
  • Vitamin D and cardiovascular disease preventiom May 2016
    Large Ongoing Random Controlled CVD trials
    No apparent attempt to trial those with low levels of vitamin D,
    No Magnesium added,
    No Omega-3 added,
    Not much vitamin D used - especially since statins used with CVD reduce the vitamin D
    No Vitamin K2 to stop Calcium increased by Vitamin D from coating the arteries


88 proofs that Vitamin D works (as of Nov 2018)

Proof that Vitamin D Works has the following Cardio related proofs

Health Problem Treat
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
HypertensionT 149 to 142 mm Hg RCT*  *, 2400 IU.  100,000 IU* 1
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU2
Diabetes T2T 62 % RCT* *, CRP reduction, 4000 IU 4
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT) 27
After Heart Attack T __+6% ejection fraction RCT, 800,000 IU one time34

Increased exercise after heart attack cuts in half the chance of death in next four years

  • Mercola May 2018
    Back in the 1960's you were supposed to have 6 weeks of bedrest following a heart attack
    Mercola does not mention that exercise might greatly reduce the risk of the heart attack as well

See also: Omega-3

33 studies in both Cardio and Omega-3 categories

See also Magnesium

Items in BOTH of the categories Cardiovascular and Magnesium (auto updated):

See also Women

Items in BOTH of the categories Cardiovascular and Women (auto updated)__

Stents do not work because there is virtually continuous plaque - March 2021

Stents to open a blocked passage, but heart attacks are not particularly associated with complete blockages
Large studies have found a slightly negative association with stings. They cause, rather than decrease heart problems
Why Angioplasty Heart Stents Don’t Work Better Video and transcript Dr. Greger March 2021

Short url = http://bit.ly/Zczfrw

Overview Cardiovascular and vitamin D        
70982 visitors, last modified 31 Jul, 2023,
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Attached files

ID Name Comment Uploaded Size Downloads
13986 Cardio RCT Grant.pdf PDF 2020 admin 04 Jul, 2020 12:54 216.05 Kb 679
11201 CoQ10 treats heart failure - Review July 2018.pdf PDF 2018 admin 14 Jan, 2019 15:39 516.10 Kb 1027
6793 CVD RCT.jpg admin 15 Jun, 2016 21:46 64.42 Kb 5630
4999 Heart Failure.pdf PDF 2013 admin 01 Feb, 2015 20:34 324.72 Kb 2392
4822 Cardio Nature 2013.jpg admin 04 Jan, 2015 15:34 83.96 Kb 7656
3642 Cardiovascular - Feb 2014.pdf PDF 2014 admin 22 Feb, 2014 12:45 953.07 Kb 2726
2869 Cardiac 2012.pdf PDF admin 04 Aug, 2013 12:28 738.94 Kb 4387
2366 Afib Mayo.pdf PDF admin 14 Apr, 2013 14:55 397.95 Kb 3413
1322 CVD 2X.jpg admin 12 May, 2012 11:37 46.99 Kb 8298