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IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021

It has been known for years that Vitamin D both prevents and treats many gut problems
Now a study finds that a drug used to treat some gut problems (Vedolizumab) does 5X better if there is even a modest level of Vitamin D
    Wonder if they have ever tried treating the gut problems by just using Vitamin D

A few charts from the study

5X better if Vitamin D > 25 ng
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Vitamin D Receptor should also be activated
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Note: Nothing special about 25 ng. The higher the vitamin D the better

VitaminDWiki

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 176 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
   you can make your own sublinqual by dissovling Vitamin D in water or using nanoemulsion form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Gut category listing contains the following

176 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 27 items along with related searches.

Vitamin D Receptor

Items in both categories Gut and Vitamin D Receptor are listed here:


The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


Note The wife of the founder had proctitus (a form of UC) flares for decades
Taking a Vitamin D receptor (Reseveratrol) and using a enema made with high-dose vitamin D water eliminated her flares in 2020
We anticipate needing to repeat the enema a couple of times a year
 
Note: Vedolizumab costs $3,290, The Vitamin D we used costs $3

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Note: Vitamin D enema works well for proctitus.
Would would need to find a time-release oral form for other UC and Crohn's

Vitamin D Levels May Predict Response to Vedolizumab - Editorial

Journal of Crohn's and Colitis, jjab105, https://doi.org/10.1093/ecco-jcc/jjab105
Giorgos Bamias, Jesús Rivera-Nieves

A remarkable expansion of therapeutic options for inflammatory bowel diseases [IBD] has arisen in recent years, mostly due to the development of monoclonal antibodies and small molecules that target inflammatory modules with presumed significance for the immunopathogenesis of disease. However, despite extraordinary progress, the long-term outcomes of novel therapies remain uniformly suboptimal, with less than half of patients achieving sustained 1-year remission on any particular treatment. This unmet need becomes even more pressing when considering the negative effect of previous treatment failures on the efficacy of subsequent medications. Precision medicine strategies have been proposed as a solution, by aiming at the sub-classification of patients into smaller, more homogeneous groups, based on the presence or absence of certain phenotype-defining biomarkers. The latter are envisioned to assist in pre-treatment selection of patients who might be most likely to respond to a particular therapy, oftentimes based on pathophysiological pathways targeted by specific drugs. In fact, increasing evidence continues to emerge reporting clinical, serological, and molecular signatures that may predict enhanced response to currently used biologics.

In this issue of JCC, Gubatan and colleagues add to that evidence by uncovering that baseline serum vitamin D [vitD] levels may serve as a predictor of therapeutic response to the anti-α4β7 integrin monoclonal antibody, vedolizumab, in patients with IBD. In particular, a value of 25[OH]D less than 25 ng/mL was associated with higher probability of primary non-response and treatment failure at 1 year. From a clinical perspective this is an important finding, given that vitD defects are highly prevalent in IBD; thus, a substantial proportion of patients would fall beneath the threshold of 25 ng/mL, rendering them prone to a suboptimal response. In the Gubatan study, 28% of patients fell in this low pre-treatment 25[OH]D group, but this percentage may be much higher in clinical practice.1 Interestingly, similar associations between baseline 25[OH]D levels and therapeutic efficacy has also been shown for anti-tumour necrosis factor [TNF] agents, whereas on-treatment increases of vitD were also noted in responders to TNF inhibitors, in both Crohn’s disease [CD] and ulcerative colitis [UC].2,3 Such evidence emphasises the need for the development of uniform definitions for vitD deficiency and insufficiency, as well as uniform recommendations for supplementation and correction of deficits.4

By definition, a biomarker needs to be simple to measure, widely available, and associated with the disease process, with ease of serial measurements. Serum vitD level fulfils those criteria, which makes it a very plausible candidate for such a role. This highly contrasts with most published work, which typically report prognostic indicators that may be cumbersome to implement. In particular, their determination requires performing repeated invasive, resource-intensive colonoscopies, evaluating on-treatment time points, analysing mucosal mRNA expression of distinct gene panels, or applying advanced technologies, all of which are largely impractical for ‘real-world’ clinical use.5–7 An added value of serum vitD level as a biomarker is that its deficits can be easily corrected. Nevertheless, the study by Gubatan does not address the important question of whether exogenous replacement of vitD may directly augment the potential response to vedolizumab. An alternative possibility is that low serum vitD content is a surrogate marker for underlying, disease-associated processes that should be corrected to maximise the potential for a therapeutic efficacy of vedolizumab.

The present study additionally provides a pathophysiological rationale in support the of the use of vitD as a biomarker for vedolizumab response, through the modification of α4β7 expression by leukocytes. In particular, the authors demonstrate an inverse correlation between serum levels of 25[OH]D and expression of α4β7 by intestinal and peripheral blood immunocytes. Furthermore, mucosal expression of vitD receptor [VDR] gene correlated negatively, whereas the VitD inactivating enzyme CYP24A1 gene correlated positively, with the expression of integrin subunits α4[ITGA4] and β7[ITGB7]. Taken together, these findings indicate that higher vitD serum concentration may decrease the expression of α4β7 by immunocytes, thus rendering them less susceptible to the inhibitory effect of vedolizumab. These data are confirmatory of previous work showing that 1,25 D3 suppressed the expression of α4β7 and CCR9 on T cells and innate lymphoid cells and antagonised the effects of the major gut-homing molecule inducer, retinoic acid.8 Nevertheless, it should be noted that when several α4β7 leukocyte subsets were separately analysed via mass cytometry, serum levels of 25[OH]D correlated with changes in integrin expression in B cells, NK cells, and monocytes, but not T cells. These current findings are in line with studies showing that responders to vedolizumab demonstrate discrete changes in innate immune cells and B lymphocytes, rather than CD4+ T cells.6,7 Thus, a paradigm shift may be taking place on our understanding of the mode of action of anti-integrin strategies, with less of an emphasis on T cell-centred biology and towards a greater emphasis of their effects on innate immune pathways and B cell biology. Given the almost universal tissue and cellular expression of VDR, the aforementioned populations are amenable to the effects of vitD and their function potentially modifiable by its deficiency. Finally, an interesting perspective may involve indirect effects of vitD via microbiota alterations, which may then affect responses to vedolizumab, as already alluded to by previous work.

Thus, should we start recommending pre-treatment evaluation of serum 25[OH]D levels in patients with IBD, based on the results presented by Gubatan et al.? If on the low side, should we consider alternatives to vedolizumab? Or, should we proactively supplement vitD with the expectation that the chance for response may increase? It may be premature to jump to such conclusions based on a single study, which should be seen as proof of concept to be validated on a larger scale and in a prospective fashion. Indeed, at the moment, a common compromising factor in biomarker research is limited reproducibility. This is oftentimes related to non-widely available state-of-the-art technologies employed in such studies. This discourages other groups to embark on cumbersome and resource-intensive validation efforts that may be then categorised by reviewers as lacking novelty. In that sense, measurement of VitD levels gives us a window of opportunity, as it is widely used in everyday clinical practice and poses no major technical challenges, and serial evaluation is feasible. An additional issue that remains is that of specificity. Are low VitD levels associated with suboptimal response specifically to vedolizumab, as supported by the evidence presented herein? Or alternatively, is it a general indicator of suboptimal response to other anti-inflammatory strategies as well, as alluded to by similar results in anti-TNF treated patients? Although the current report opens new frontiers, additional work lies ahead before the conceptual advance acquires true translational significance.


The Study

Vitamin D is Associated with α4β7+ Immunophenotypes and Predicts Vedolizumab Therapy Failure in Patients with Inflammatory Bowel Disease
J Crohns Colitis . 2021 Jun 28;jjab114. doi: 10.1093/ecco-jcc/jjab114
John Gubatan 1 2, Samuel J S Rubin 1 3, Lawrence Bai 1 3, Yeneneh Haileselassie 1, Steven Levitte 1, Tatiana Balabanis 1, Akshar Patel 1, Arpita Sharma 1, Sidhartha R Sinha 1, Aida Habtezion 1 3

Background and aims: Vitamin D downregulates the in vitro expression of the gut-tropic integrin α4β7 on immune cells. The clinical relevance of this finding in patients with inflammatory bowel disease (IBD) is unclear. We tested the hypothesis that vitamin D is associated with α4β7 immunophenotypes and risk of vedolizumab (anti- α4β7) failure in IBD.

Methods: We performed single-cell immunophenotyping of peripheral and intestinal immune cells using mass cytometry (CyTOF) in vedolizumab-naïve patients with IBD (N=48). We analyzed whole-genome mucosal gene expression (GSE73661) from GEMINI I and GEMINI long-term safety (LTS) to determine the association between vitamin D receptor (VDR) and integrin alpha-4 (ITGA4) and beta-7 (ITGB7) genes. We estimated the odds of vedolizumab failure with low pre-treatment vitamin D in a combined retrospective and prospective IBD cohort (N= 252) with logistic regression.

Results: Immunophenotyping revealed that higher 25(OH)D was associated with decreased α4β7+ peripheral blood mononuclear cells (R = -0.400, P < 0.01) and α4β7+ intestinal leukocytes (R = -0.538, P= 0.03). Serum 25(OH)D was inversely associated with α4β7+ peripheral B cells and natural killer (NK) cells and α4β7+ intestinal B cells, NK cells, monocytes, and macrophages. Mucosal expression of VDR was inversely associated with ITGA4 and ITGB7 expression. In multivariate analysis, 25(OH)D < 25 ng/mL was associated with increased vedolizumab primary non-response during induction (OR 26.10, 95% CI 14.30-48.90, P<0.001) and failure at 1-year follow-up (OR 6.10, 95% CI 3.06-12.17, P<0.001).

Conclusions: Low serum 25(OH)D is associated with α4β7+ immunophenotypes and predicts future vedolizumab failure in patients with IBD.


Created by admin. Last Modification: Tuesday June 29, 2021 19:59:21 GMT-0000 by admin. (Version 7)

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15844 UC.jpg admin 29 Jun, 2021 19:52 85.51 Kb 64
15843 Vedo HR 5.jpg admin 29 Jun, 2021 19:17 41.04 Kb 69
15842 VDR FEDO.jpg admin 29 Jun, 2021 19:17 19.94 Kb 66
15841 Vedo.jpg admin 29 Jun, 2021 19:17 32.71 Kb 70
15840 Vedolizumab.pdf PDF 2021 admin 29 Jun, 2021 19:16 1.22 Mb 19
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