FACT: Vitamins, such as vitamin D, are needed to reduce hair loss
FACT: Chemotheraphy reduces vitamin D
OBSERVATION: Vitamin D reduces hair loss due to chemotherapy: reasons include:
- Vitamin D can reduce the amount of chemo needed, so less hair killed off
- Less chemo results in less reduction in Vitamin D
- Vitamin D can keep the hair healthy.
Google search "hair loss" chemotherapy "vitamin d" 3,60,000 hits Nov2019
J Cosmet Dermatol doi: 10.1111/jocd.14421
Kriteeka Saini 1, Venkataram Mysore 1
Background: Vitamin D, a vitamin and hormone, plays an important role in dermatology and dermatotherapeutics, due to its anti-inflammatory and immunomodulatory properties, and regulation of keratinocyte differentiation and proliferation. It also affects the hair cycle, and its role in hair loss is under constant research.
Objectives: This review aims to give a brief overview of vitamin D biology within the hair follicle, role in the etiopathogenesis, and rationale for supplementation in various alopecias.
Methods: A PubMed literature search was performed to review relevant current literature and studies investigating the role of vitamin D in the etiopathogenesis, as a supplement and a potential therapeutic modality in hair loss.
Results and conclusion: Vitamin D is intricately involved in various signaling pathways of growth and differentiation of hair follicles. Most studies show an inverse relationship between serum vitamin D levels and non-scarring alopecias such as telogen effluvium, androgenetic alopecia, alopecia areata, and trichotillomania. Vitamin D deficiency is also associated with scarring alopecia. However, conclusive studies to demonstrate the benefit of vitamin D administration in correcting hair loss and managing these conditions are lacking. Hence, further studies are needed before vitamin D can be routinely
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- Amor KT, Rashid RM, Mirmirani P. Does D matter? The role of vitamin D in hair disorders and hair follicle cycling. Dermatol Online J. 2010;16(2):3.
- Gerkowicz A, Chyl-Surdacka K, Krasowska D, Chodorowska G. The role of vitamin D in non-scarring alopecia. Int J Mol Sci. 2017;18:2653.
- Lin X, Meng X, Song Z. Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. Am J Transl Res. 2019;11:5285-5300.
- Daroach M, Narang T, Saikia UN, et al. Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm. Int J Dermatol. 2018;57:217-222.
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- Rasheed H, Mahgoub D, Hegazy R, et al. Serum ferritin and vitamin d in female hair loss: do they play a role? Skin Pharmacol Physiol. 2013;26:101-107.
- Fawzi MMT, Mahmoud SB, Ahmed SF, Shaker OG. Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia. J Cosmet Dermatol. 2016;15:318-323.
- Tamer F, Yuksel ME, Karabag Y. Serum ferritin and vitamin D levels should be evaluated in patients with diffuse hair loss prior to treatment. Postepy Dermatol Alergol. 2020;37:407-411.
- Poonia K, Thami GP, Bhalla M, et al. NonScarring diffuse hair loss in women: a Clinico-Etiological Study from tertiary care center in North-West India. J Cosmet Dermatol. 2019;18:401-407.
- Nayak K, Garg A, Mithra P, Manjrekar P. Serum vitamin D3 levels and diffuse hair fall among the student population in South India: a case-control study. Int J Trichology. 2016;8:160-164.
- Cheung EJ, Sink JR, English Iii JC. Vitamin and mineral deficiencies in patients with telogen effluvium: a retrospective cross-sectional study. J Drugs Dermatol. 2016;15:1235-1237.
- Ruiz-Tagle S, Figueira M, Vial-Letelier V, et al. Micronutrients in hair loss. Our Dermatology Online. 2018;9:320-328.
- Sattar F, Almas U, Ibrahim NA, et al. Efficacy of oral vitamin D3 therapy in patients suffering from diffuse hair loss (Telogen Effluvium). J Nutr Sci Vitaminol (Tokyo). 2021;67:68-71.
- Mysore V, Parthasaradhi A, Kharkar R, et al. Expert consensus on the management of Telogen Effluvium in India. Int J Trichology. 2019;11:107-112.
- Banihashemi M, Nahidi Y, Meibodi NT, et al. Serum vitamin D3 level in patients with female pattern hair loss. Int J Trichology. 2016;8:116-120.
- Zhao J, Sheng Y, Dai C, et al. Serum 25 hydroxyvitamin D levels in alopecia areata, female pattern hair loss, and male androgenetic alopecia in a Chinese population. J Cosmet Dermatol. 2020;19:3115-3121.
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My having a high level of vitamin D for over 2 years helped reduce many aches and pains, but did not stop or even slow my hair loss (age 66)
Even taking all of the bone/vitamin D cofactors did not stop hair loss (Magnesium, Silicon, Boron, etc)
However, 2 months ago I decided to add scalp massage, which had really helped my father re-populate his scalp
(he was a carpenter who worked outdoors most of his life, probably getting plenty of vitamin D)
Nightly 3 minute scalp massage (to increase blood circulation) resulted in detectable hair re-growth in 2 weeks and excellent regrowth in 6 weeks.
I leave the scalp massager plugged in next to the bed so that it takes no time to setup for the nightly massage.
Update 2021 Using a muscle massage gun - far deeper and feels better
Perhaps just massage would have helped, I do not know.
Conclusion for others: None: I have no idea if the combination will work for you.
There are a huge number of scalp massagers sold on Amazon - both mechanical and electric
I happened to purchase an electric massager made by Wahl for $22, which has a hair attachment (not shown)
Feb 2010 Meta-analysis of Vitamin D and Hair Loss
"...Limited studies have been done in humans to elaborate the role of vitamin D in the hair cycle. A potential application for vitamin D is in chemotherapy-induced hair loss. Topical calcitriol has been shown to protect against chemotherapy-induced alopecia caused by paclitaxel and cyclophosphamide. However, topical calcitriol failed to protect against chemotherapy-induced hair loss caused by a combination of 5-fluorouracil, doxorubicin, and cyclophosphamide and a combination of cyclophosphamide, methotrexate, and 5-fluorouracil 36, 37.”
Archives of Biochemistry and Biophysics, doi:10.1016/j.abb.2011.10.002
Marie B. Demay , Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom St, Thier 11, Boston, MA 02114
The Vitamin D receptor (VDR) plays a critical role in epidermal homeostasis. The ligand-dependent actions of the VDR attenuate epidermal keratinocyte proliferation and promote keratinocyte differentiation. Calcium can compensate for the absence of the VDR in maintaining a normal program of epidermal keratinocyte differentiation both in vitro and in vivo. In contrast, the effects of VDR ablation on the hair follicle cannot be prevented by maintaining normal calcium levels and are independent of 1,25-dihydroxyvitamin D. These actions of the VDR are critical in the keratinocyte stem cell population that resides in the bulge region of the hair follicle. Absence of a functional VDR leads to a self-renewal and lineage progression defect in this population of stem cells, resulting in the absence of post-morphogenic hair cycles. The molecular partners and downstream target genes of the VDR in this unique population of cells have not yet been identified.
Skin Pharmacol Physiol. 2013;26(2):101-7. doi: 10.1159/000346698. Epub 2013 Feb 20.
Rasheed H1, Mahgoub D, Hegazy R, El-Komy M, Abdel Hay R, Hamid MA, Hamdy E.
1Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
AIM: Evaluation of serum ferritin and vitamin D levels in females with chronic telogen effluvium (TE) or female pattern hair loss (FPHL), in order to validate their role in these common hair loss diseases.
METHODS: Eighty females (18 to 45 years old) with hair loss, in the form of TE or FPHL, and 40 age-matched females with no hair loss were included in the study. Diagnosis was based upon clinical examination as well as trichogram and dermoscopy. Serum ferritin and vitamin D2 levels were determined for each participant.
RESULTS: Serum ferritin levels in the TE (14.7 ± 22.1 μg/l) and FPHL (23.9 ± 38.5 μg/l) candidates were significantly lower than in controls (43.5 ± 20.4 μg/l). Serum vitamin D2 levels in females with
- TE (28.8 ± 10.5 nmol/l) and
- FPHL (29.1 ± 8.5 nmol/l) were significantly lower than in
- controls (118.2 ± 68.1 nmol/l; p < 0.001).
These levels decreased with increased disease severity.
Serum ferritin cut-off values for TE and FPHL were 27.5 and 29.4 μg/l, respectively, and those for vitamin D were 40.9 and 67.9 nmol/l.
CONCLUSION: Low serum ferritin and vitamin D2 are associated with hair loss in females with TE and FPHL. Screening to establish these levels in cases of hair loss and supplementing with them when they are deficient may be beneficial in the treatment of disease.
Indian Dermatol Online J. 2016 Sep-Oct;7(5):371-377
Bakry OA1, El Farargy SM1, El Shafiee MK2, Soliman A1.
BACKGROUND: Alopecia areata (AA) is a common, recurrent, autoimmune hair disorder. It has been found that vitamin D deficiency is associated with many autoimmune diseases.
AIMS: The current study aimed to estimate serum levels of 25-hydroxy vitamin D in patients with AA.
MATERIALS AND METHODS: This case-control study included 60 patients with AA and 60 age, gender, skin phototype, and body mass index-matched healthy subjects as a control group. Levels of serum 25-hydroxy vitamin D were estimated using ELISA technique.
RESULTS: Serum 25-hydroxy vitamin D levels were significantly lower in AA cases when compared with healthy controls (P < 0.001). The least values were significantly associated with alopecia totalis/universalis compared with patchy AA (P < 0.001) and ophiasis (P = 0.04). Severe AA showed significantly the lowest vitamin D levels compared with cases with mild (P = 0.002) and moderate disease (P = 0.03). A significant inverse correlation was found between 25-hydroxy vitamin D levels and age of the patients (r = -0.38; P = 0.03). There was no significant association between serum 25-hydroxy vitamin D levels and gender, disease duration, disease recurrence, nail affection, duration of sun exposure/day, or positive family history of AA.
CONCLUSION: AA patients have lower levels of 25-hydroxy vitamin D than healthy subjects. More studies are required to assess the value of vitamin D supplementation in the treatment of that disease.
Download the PDF from VitaminDWiki
Serum Vitamin D3 Level in Patients with Female Pattern Hair Loss.
Int J Trichology. 2016 Jul-Sep;8(3):116-20. doi: 10.4103/0974-7753.188965.
Banihashemi M1, Nahidi Y1, Meibodi NT2, Jarahi L3, Dolatkhah M4. IRAN
BACKGROUND: Female pattern hair loss (FPHL) is the most common cause of alopecia in women, characterized by diffuse nonscarring hair loss in frontal, central, and parietal areas of the scalp. Pathophysiology of FPHL is still not well known, and it is probably a multifactorial genetic trait. FPHL is also observed in women without increased androgen levels, which raises the likelihood of androgen-independent mechanisms and explains the lack of response to antiandrogen treatments in some patients. Vitamin D is a factor that has recently been considered in dealing with these patients. The purpose of this study was to evaluate the serum levels of Vitamin D in patients with FPHL and compare it with healthy controls.
METHODS: In this case-control study, 45 women with FPHL were evaluated as well as the same number of healthy women matched for age, hours spent under sunlight per day, and body mass index. Serum 25(OH) D3 level was measured using ELISA.
RESULTS: 60% of FPHL patients were in 15-30 years old age group with the mean standard deviation (SD) age of 29.11 (7.30) years. In the majority of patients (66.7%), severity of hair loss was Ludwig I. Mean (SD) serum Vitamin D3 level in patient and control group was 13.45 (8.40) and 17.16 (8.96), respectively. T-test showed a significant difference between the two groups in terms of Vitamin D3 serum levels (P = 0.04).
CONCLUSIONS: This study indicated the correlation between the incidence of FPHL and decreased serum levels of Vitamin D3. It is recommended to evaluate serum Vitamin D3 levels as well as other hormone assays in these patients.
PMID: 27625563 DOI: 10.4103/0974-7753.188965
Download the PDF from VitaminDWiki
- Chemotherapy hair loss – prevented or treated by Vitamin D, US patent application – Nov 2019
- Hair loss strongly associated with poor vitamin D receptors– Dec 2016
- Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019
- Temporary hair loss (Telogen Effluvium) treated by Vitamin D (200,000 IU, twice a month) - March 2021
- Spot Baldness (Alopecia Areata) associated with low vitamin D – many studies
- Diffuse hair loss - 2009.pdf not just getting older
- Vitamin D2 patent granted to prevent hair loss during chemotherapy – 2002
- We suspect the vitamin D3 would work as well, if not better than D2
- A patent for a vitamin D treatment of a health problem is always a good indication that it probably works
- Redhead – Red hair - vitamin D
- Red hair apparently allows more production of vitamin D from the same amount of sunlight
- Vitamin D Shows Promise in Curing Baldness – July 2012
- Vitamin D and Hair Loss (Alopecia): New Research Confirms Link Jan 2012, discussses
mutated Vitamin D receptors and hair loss in mice - California study
study in Texas
another mouse and VDR study from Mass General
California study with nude mice and VDR
- Vitamin D deficiency causing more women to seek hair transplants in the Gulf May 2013
Women in the Middle East have such low levels of vitamin D that some are losing their hair.
Only 3% of the people going to hair clinics in Europe are women, but 20% are women in the Middle East
CLICK HERE for vitamin D deficiency in the Middle East
- What Is the Connection Between Vitamin D and Hair Loss?
Research using hairless mice shows that vitamin D protects against hair loss caused by chemotherapy administered during cancer treatment, but the results have not been replicated in humans.
- 7 Reasons Women Lose Their Hair — And 7 Fixes
1 reason is low vitamin D - only 1 sentence: Huffingpost July 2015
- Vitamin D deficiency in alopecia areata 2014
Vitamin D deficiency: 91% in those with AA, 33% in controls
- Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata April 2013
Download the PDF from VitaminDWiki
- Vitamind3Blog - Does Vitamin D Deficiency Cause Hair Loss? Feb 2011 with interesting comments
- Vitamind3Blog - Update Jan 2012 with some of the items below
- Vitamin D3 analogs stimulate hair growth in nude mice 2002 PDF on-line
- Sydney Morning Herald Feb 2010
Hormone in pill and vitamin D blamed for women's hair loss
- Does D matter? The role of vitamin D in hair disorders and hair follicle cycling - Feb 2010 full text of peer-reviewed publication is on-line
MEDLINE review (1955-July 2009) RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.
- Exposed: Symptoms Of Vitamin D Deficiency In Ladies... Aug 2011
- Vitamin D and Male Pattern Hair Loss: Is There a Link? Aug 2016
Article decides - probably there is a link
- Vitamin D Level in Alopecia Areata July 2017
AA 17 ng, Not AA 41 ng. free PDF online
- Absence of vitamin D receptor (VDR)-mediated PPARγ suppression causes alopecia in VDR-null mice March 2017
alopecia in mice laking a Vitamin D Receptor - free PDF online
- Her hair grew back after 6 months of 2,000 IU vitamin D 10 minute YouTube video April 2019
- This Is Why You Have Gray Hair Mercola, March 2016
Obesity, Thyroid disorders, anemia and vitiligo
"people with premature graying but no other identifiable risk factor were 4.4 times as likely to have osteopenia"
- What gray hair says about your health Jan 2020
- You may have a vitamin deficiency - Vitamin D, Vitamin B12
- Your immune system may cause sudden graying
- Gray is in your genes
- You are (or were) a smoker
- Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials
- Jan 2019 Deepdive
- Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial - Dec 2018 Red LEDs in cap 20 min per session, three times per week, over a 24-week period
I've got an LLLT, I will give it a try - Henry Lahore, Feb 2019
- Note: one non-hair study found that LLLT increased Vitamin D Levels
Started growing my beard at age 70 (2016)
Facial hair and head hair growing well
Vitamin D and cofactors - which include Zinc
Google Search for Beard and Vitamin D ==> 200,000 web pages
Google Search for Beard and Zinc ==> 400,000 web pages
Short url = http://is.gd/HairVitD