Loading...
 
Toggle Health Problems and D

Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022


The Association of Vitamin D and Its Pathway Genes' Polymorphisms with Hypertensive Disorders of Pregnancy: A Prospective Cohort Study

Nutrients . 2022 Jun 6;14(11):2355. doi: 10.3390/nu14112355.
Shuting Si 1 2, Minjia Mo 1 2, Haoyue Cheng 1 2, Zhicheng Peng 1 2, Xialidan Alifu 1 2, Haibo Zhou 1 2, Peihan Chi 1 2, Yan Zhuang 1 2, Yunxian Yu 1 2

Objective: We aimed to explore the effect of single nucleotide polymorphism (SNP) in the genes of the vitamin D (VitD) metabolic pathway and its interaction with VitD level during pregnancy on the development of hypertensive disorders of pregnancy (HDP).

Methods: The study was conducted in the Zhoushan Maternal and Child Health Care Hospital, China, from August 2011 to May 2018. The SNPs in VitD metabolic pathway-related genes were genotyped. Plasma 25-hydroxyvitamin vitamin D (25(OH)D) levels was measured at first (T1), second (T2), and third (T3) trimesters. The information of systolic blood pressure (SBP) and diastolic blood pressure (DBP), and the diagnosis of HDP were extracted from the electronic medical record system. Multivariable linear and logistic regression models and crossover analysis were applied.

Results: The prospective cohort study included 3699 pregnant women, of which 105 (2.85%) were diagnosed with HDP. After adjusting for potential confounders, VitD deficiency at T2, as well as the change of 25(OH)D level between T1 and T2, were negatively associated with DBP at T2 and T3, but not HDP.
Polymorphisms in CYP24A1, GC, and LRP2 genes were associated with blood pressure and HDP.
In addition, VitD interacted with CYP24A1, GC, and VDR genes' polymorphisms on blood pressure.
Furthermore, participants with polymorphisms in CYP24A1-rs2248137, LRP2-rs2389557, and LRP2-rs4667591 and who had VitD deficiency at T2 showed an increased risk of HDP.

Conclusions: The individual and interactive association between VitD deficiency during pregnancy and SNPs in the genes of the VitD metabolic pathway on blood pressure and HDP were identified.
 Download the PDF from VitaminDWiki


VitaminDWiki - 40 studies in both categories Hypertension and Pregnancy

This list is automatically updated


VitaminDWiki - 22 studies in both categories Pregnancy and Vitamin D Receptor

This list is automatically updated


VitaminDWiki - 10 studies in both categories Pregnancy and GC (binding protein)

This list is automatically updated


VitaminDWiki - CYP24A1 enzyme and Vitamin D


VitaminDWiki - Vitamin D charts

Review of 11 Vitamin D genes – Nov 2017 has
Blood Test Misses a lot (VDW 3439)

Image


Created by admin. Last Modification: Saturday June 11, 2022 13:32:41 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
17817 HT pregnancy.pdf PDF 2022 admin 10 Jun, 2022 12:53 312.99 Kb 13
See any problem with this page? Report it (WORKS NOV 2021)