Non-daily (Bolus) is better:
- Better compliance for everyone
- Fewer opportunities to forget.
- If happen to forget, just take the pill days or weeks later
- Fewer times to have to take a pill - for those who dislike doing so
- Non-daily is better the ~20% who have a poor Vitamin D Receptor
- A high concentration gradient is one of 14 ways to get past Vitamin D Receptor limitations
- So, while 80% get no extra benefit from non-daily dosing, 20% will get an extra benefit
- Vitamin D given daily, weekly, or monthly has similar response (116 RCTs) – meta-analysis Aug 2023
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Monthly vitamin D dosing better for children than daily (again) - Oct 2023
- VitaminDWiki – Weekly, Monthly Vitamin D are typically better than daily - many studies
- VitaminDWiki - Take vitamin D3 daily, weekly, or bi-weekly - many studies
31 Better than Daily studies - Examples of non-daily vitamin D studies (does not include loading dose)
- Some people mistakenly believe that the body cannot store vitamin D, so must be taken daily
- Loading Dose in VitaminDWiki
- 12+ VitaminDWiki pages with BETTER THAN DAILY in title
- Intervention - non-daily AND Diabetes
- Intervention - non-daily AND Pain
261 studies used Non-daily intervention
VitaminDWiki – Weekly, Monthly Vitamin D are typically better than daily - many studies
VitaminDWiki - Take vitamin D3 daily, weekly, or bi-weekly - many studies
The Vitamin D Receptor is activated by high concentration gradient and 13+ other things
+
31 Better than Daily studies - wiki page:
- Weekly, Monthly Vitamin D are typically better than daily - many studies
- Monthly vitamin D dosing better for children than daily (again) - Oct 2023
- Cancers reduced after 2 years of 2000 IU Vitamin D daily (2nd RCT) – RCT Aug
- Vitamin D given daily, weekly, or monthly has similar response (116 RCTs) – meta-analysis Aug 2023
- Vitamin D response independent of dosing interval – meta-analysis July 2023
- Depression is especially reduced by large intermittent doses of vitamin D – meta-analysis – April 2023
- Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022
- Vitamin D: Bolus is Bogus (if more than 17 days between oral doses) – Oct 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- 50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- How I am reminded to take my Vitamin D once every 4 days
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Better than Daily
- Weekly Vitamin D to mother after birth much better than daily - RCT Aug 2018
- Vitamin D dosing - weekly may be better than daily – video Aug 2018
- Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
- Vitamin D given weekly better than daily (Nursing home, 5,600 IU weekly) – Aug 2018
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing had higher response than 3 per month – RCT Jan 2018
- Monthly vitamin D dosing is better than daily dosing for children and elderly (more likely to be taken) – June 2017
- Optimal vitamin D supplementation strategies (D3 - weekly or monthly) – Feb 2017
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
- Can get 50,000 IU Vitamin D anywhere on the globe
- Take vitamin D3 daily, weekly, or bi-weekly
Examples of non-daily vitamin D studies (does not include loading dose)
One pill every two weeks gives you all the vitamin D most adults need
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
22 diseases proven to be prevented/treated by biweekly Vitamin D
10 additional diseases with weekly Vitamin D
Some people mistakenly believe that the body cannot store vitamin D, so must be taken daily
All humans and animals can store Vitamin D, which was necessary to survive rainy seasons, winters, etc.
Example of mistaken belief: Do You Take Your Vitamin D Daily? Grassrootshealth June 2019
Loading Dose in VitaminDWiki
- Overview Loading of vitamin D - which is sometimes just a single dose
- Loading dose for Vitamin D category listing has
200 items along with related searches - Loading doses typically restore Vitamin D levels in 1 to 30 days
- Loading doses should be followed by maintenance doses - which can be daily or bolus
12+ VitaminDWiki pages with BETTER THAN DAILY in title
This list is automatically updated
Items found: 14
Intervention - non-daily AND Diabetes
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
Intervention - non-daily AND Pain
- Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023
- Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg) – Aug 2023
- Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
- Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months – May 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
261 studies used Non-daily intervention Diabetes 22; Better than daily 18; Pregnancy 17; Loading dose 16; Pain - chronic 13; Breathing 12; How much Vitamin D 11; Obesity 10; Infant-Child 10; Injection 9; Gut 8; Depression 8; Cardiovascular 7; Falls and Fractures 7; Women 7; Multiple Sclerosis 6; Virus 6; Sports 6; Trauma and surgery 6; Youth 5; Seniors 5; Hypertension 5; HIV 5; Sleep 4; Liver 4; Skin - Dark 4; Kidney 4; Immunity 4; Cognitive 4; How; when to take Vit. D 4 as of Oct 2022
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