Non-daily (Bolus) is virtually always better: -Reasons include:
- Better compliance
- Fewer opportunities to forget
- Fewer times to have to take a pill - for those who dislike it
- High concentration resulting from infrequent dosing gets past some gene and gut limitations
- Note: 24+ studies have found non-daily to be better than daily
I am unaware of a single study that has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019
A few studies have found that daily was just as good as weekly
- Note: 24+ studies have found non-daily to be better than daily
Table of contents
- Take vitamin D3 daily, weekly, or bi-weekly - many studies
- Better than Daily studies
- Examples of non-daily vitamin D studies (does not include loadng dose)
- Intervention - non daily AND Diabetes
- Intervention - non daily AND Pain
- Daily lasting 14 weeks was beter than weekly lasting only 8 weeks - June 2020
- Daily better than weekly - but used 70,000 total per week vs. 50,000 once a week - 2021
- Loading Dose in VitaminDWiki
- All studies associated with Non-daily intervention
Take vitamin D3 daily, weekly, or bi-weekly - many studies
- The Vitamin D Receptor is activated by high concentration gradient and 12+ other things
Better than Daily studies
- wiki page:
- Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022
- Vitamin D: Bolus is Bogus (if more than 17 days between oral doses) – Oct 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- 50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020
- 20,000 IU of Vitamin D weekly gave many benefits – RCT Aug 2019
- How I am reminded to take my Vitamin D once every 4 days
- Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
- Better than Daily
- Vitamin D dosing - weekly may be better than daily – video Aug 2018
- Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018
- Vitamin D given weekly better than daily (Nursing home, 5,600 IU weekly) – Aug 2018
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018
- Monthly vitamin D dosing had higher response than 3 per month – RCT Jan 2018
- Monthly vitamin D dosing is better than daily dosing for children and elderly (more likely to be taken) – June 2017
- Optimal vitamin D supplementation strategies (D3 - weekly or monthly) – Feb 2017
- Vitamin D – monthly dosing was better than daily with Calcium – RCT Dec 2015
- Can get 50,000 IU Vitamin D anywhere on the globe
- Take vitamin D3 daily, weekly, or bi-weekly
Examples of non-daily vitamin D studies (does not include loadng dose)
One pill every two weeks gives you all the vitamin D most adults need
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017
22 diseases proven to be prevented/treated by biweekly Vitamin D
10 additional diseases with weekly Vitamin D
Intervention - non daily AND Diabetes
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
Intervention - non daily AND Pain
- Pain reduced by Vitamin D (60K weekly, then monthly) plus daily Calcium in 3 months – May 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
Some people believe that daily Vitamin D dosing is needed while breastfeeding or supplementing infants
However, it turns out that infants, like all humans and animals, can store Vitamin D, which is necessary to exist in rainy seasons, etc.
Daily lasting 14 weeks was beter than weekly lasting only 8 weeks - June 2020
Daily oral vitamin D3 regimen in similar cumulative doses is more effective than weekly oral vitamin D3 regimen in patients with vitamin D deficiency
Note: Weekly lasted only 8 weeks, daily lasted for 14 weeks
 Download the PDF from VitaminDWiki
Daily better than weekly - but used 70,000 total per week vs. 50,000 once a week - 2021
Vitamin D supplementation: better daily or by bolus?
 Download the PDF from VitaminDWiki
Loading Dose in VitaminDWiki
- Overview Loading of vitamin D - which is sometimes just a single dose
- Loading dose for Vitamin D category listing has
191 items along with related searches - Loading doses typically restore Vitamin D levels in 1 to 30 days
- Loading doses should be followed by maintenance doses - which can be daily or bolus
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All studies associated with Non-daily intervention
Diabetes 22; Better than daily 18; Pregnancy 17; Loading dose 16; Pain - chronic 13; Breathing 12; How much Vitamin D 11; Obesity 10; Infant-Child 10; Injection 9; Gut 8; Depression 8; Cardiovascular 7; Falls and Fractures 7; Women 7; Multiple Sclerosis 6; Virus 6; Sports 6; Trauma and surgery 6; Youth 5; Seniors 5; Hypertension 5; HIV 5; Sleep 4; Liver 4; Skin - Dark 4; Kidney 4; Immunity 4; Cognitive 4; How; when to take Vit. D 4 as of Oct 2022
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