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Epstein-Barr Virus increases the risk of many health problems – many studies

Epstein-Barr virus infection in the development of neurological disorders - 2020

Drug Discovery Today: Disease Models Volume 32, Part A, Autumn 2020, Pages 35-52 https://doi.org/10.1016/j.ddmod.2020.01.001
Samantha S.Soldan ssoldan at wistar.org. Paul M.Lieberman

Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult population. Yet, it also increases risk for certain cancers and auto-immune disorders depending on complex viral, host, and environmental factors that are only partly understood. EBV latent infection is found predominantly in memory B cells, but the natural infection cycle and pathological aberrations enable EBV to infect numerous other cell types, including
oral, nasopharyngeal, and gastric epithelia, B-, T-, and NK-lymphoid cells, myocytes, adipocytes, astrocytes, and neurons.
EBV infected cells, free virus, and gene products can also be found in the CNS. In addition to the direct effects of EBV on infected cells and tissue, the effect of chronic EBV infection on the immune system is also thought to contribute to pathogenesis, especially auto-immune disease. Here, we review properties of EBV infection that may shed light on its potential pathogenic role in neurological disorders.
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Epstein-Barr Virus and Neurological Diseases - Jan 2022

Front Mol Biosci. 2021; 8: 816098. doi: 10.3389/fmolb.2021.816098
Nan Zhang, 1 , 2 Yuxin Zuo, 1 Liping Jiang, 1 Yu Peng, 1 Xu Huang, 1 and Lielian Zuo 1 ,*

Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a double-stranded DNA virus that is ubiquitous in 90–95% of the population as a gamma herpesvirus. It exists in two main states, latent infection and lytic replication, each encoding viral proteins with different functions. Human B-lymphocytes and epithelial cells are EBV-susceptible host cells. EBV latently infects B cells and nasopharyngeal epithelial cells throughout life in most immunologically active individuals. EBV-infected cells, free viruses, their gene products, and abnormally elevated EBV titers are observed in the cerebrospinal fluid. Studies have shown that EBV can infect neurons directly or indirectly via infected B-lymphocytes, induce neuroinflammation and demyelination, promote the proliferation, degeneration, and necrosis of glial cells, promote proliferative disorders of B- and T-lymphocytes, and contribute to the occurrence and development of nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, acute cerebellar ataxia, meningitis, acute disseminated encephalomyelitis, and brain tumors. However, the specific underlying molecular mechanisms are unclear. In this paper, we review the mechanisms underlying the role of EBV in the development of central nervous system diseases, which could bebeneficial in providing new research ideas and potential clinical therapeutic targets for neurological diseases.
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The Virus That Causes Mono Does a Lot More Than That - March 2022

The Atlantic
autoimmune disorders such as rheumatoid arthritis, lupus, and multiple sclerosis
cancers, chronic fatigue.

  • "The recent study from Harvard’s Ascherio got around this by looking at a massive archive of serum samples taken from people over 20 years. The collection came from the Department of Defense, which stores serum from routine tests for HIV. Among the 10 million adults with samples in the repository, researchers were able to find enough people who were initially negative for EBV but then contracted it during the 20-year period. And those who did get the virus were 32 times as likely to develop multiple sclerosis as those who did not. A second study from Stanford adds a possible causation to this correlation: Some multiple-sclerosis patients have antibodies that bind both an EBV protein and a protein in the brain, which is erroneously targeted by the immune system in multiple sclerosis. This kind of cross-reaction has long been suspected in MS but only now identified. “It’s just like a great volcano of information,” says Rickinson about the recent studies. As with EBV-associated cancers, though, only a tiny sliver of people infected with the virus end up developing multiple sclerosis, so some other trigger or triggers must also be in play. We’re only at the beginning of understanding this process."
  • "And in the 1980s, doctors noticing the similarity had begun diagnosing chronic Epstein-Barr virus syndrome in patients whose mono-like symptoms of fatigue and sore throat did not go away for months. Eventually, however, experts took Epstein-Barr out of the name and gave it the more general term of chronic fatigue syndrome, because EBV does not seem to be the sole cause of such symptoms."

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EBV caused 137,900 – 208,700 cancer deaths (1% of total) in 2020

Estimating the global burden of Epstein–Barr virus-related cancers - Oct 2021
Nasopharyngeal carcinoma, Gastric carcinoma, Hodgkin lymphoma, Burkitt lymphoma, Diffuse large B-cell lymph, Extranodal NK/T-cell lymphoma, Nasal type
Note by VitaminDWiki other viruses cause other cancer deaths.
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VitaminDWiki titles with EPSTEIN or EBV (16 as of Oct 2022 )

This list is automatically updated

Items found: 16
Title Modified
Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies 02 Oct, 2022
Hypothesis: Smoking reduces Vitamin D, which activates EBV, which causes lung cancer – Jan 2022 04 Mar, 2022
Epstein-Barr Virus increases the risk of many health problems – many studies 03 Mar, 2022
Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022 20 Feb, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022 15 Jan, 2022
Epstein Barr Virus and Chronic Fatigue Syndrome 13 Dec, 2021
Multiple Sclerosis etc. strongly associated with Epstein-Barr virus (and vitamin D) 12 Dec, 2021
Epstein-Barr virus appears to cause Long-Haul and Chronic fatiure Syndrome (Vitamin D might help) 11 Dec, 2021
Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010 17 Oct, 2021
Multiple Sclerosis risk increased if both Epstein-Bar Virus and low sun (vitamin D) – Aug 2021 26 Aug, 2021
Hypothesis of Autoimmunity which includes Epstein-Barr Virus and Vitamin D Deficiency – 2012 26 Aug, 2021
Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Zoster, Epstein, Hepatitis, RSV) – March 2011 08 Feb, 2021
Multiple Sclerosis risk factors – Vitamin D, parasites, and EBV – 2015 05 Jan, 2016
Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis) – March 2011 04 Oct, 2014

VitaminDWiki titles with LONG-HAUL (21 as of Feb 2022)

Items found: 35
Title Modified
Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 30 Oct, 2022
Chronic Fatigue Syndrome and long-haul COVID-19 26 Sep, 2022
Long-Haul more prevalent among seniors - June - 2022 26 Jun, 2022
Long-Haul can now be claimed a work disability in the UK – June 2022 24 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
COVID Spike persists in Long Haul - June 2022 18 Jun, 2022
COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022 17 Jun, 2022
COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021 10 Jun, 2022
Mass disabling events: Polio, WWII, HIV, and COVID Long-Haul - June 2022 06 Jun, 2022
1 in 5 Americans who got COVID had Long-Haul for a while - CDC May 2022 27 May, 2022
Long-Haul COVID after 3 months – only 5 percent had even 30 ng of Vitamin D – April 2022 04 May, 2022
Hypothesis: 2 long-haul COVIDs: had mild symptoms and had needed ICU - April 2022 15 Apr, 2022
COVID Long-Haul at 49 weeks: overactive immune system, type O blood - March 2022 07 Apr, 2022
Children have less severe COVID, but just as much long-haul as adults - April 2022 06 Apr, 2022
Dietary Recommendations for COVID Long-Haul – March 2022 20 Mar, 2022
Mild Long-Haul 4.2 X more likely if type O blood - preprint March 16, 2022 20 Mar, 2022
Long-Haul COVID is somewhat less of a problem if vaccinated – Nov 2021 18 Mar, 2022
COVID Long-Haul NYT - Feb 2022 19 Feb, 2022
COVID Long-Haul fought by probiotics - Jan 2022 29 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
Some COVID-19 infection become COVID Long-Haul - Nov 2020 15 Dec, 2021
Epstein-Barr virus appears to cause Long-Haul and Chronic fatiure Syndrome (Vitamin D might help) 11 Dec, 2021
Long-haul after breakthrough COVID – Nov 2021 11 Dec, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 07 Aug, 2021
Long-haul COVID-19 blood tests at Mayo include vitamin D (but no results published) – July 2021 20 Jul, 2021
Most people with Long-Haul COVID-19 have low Vitamin D – July 2021 15 Jul, 2021
‘Long haul’ COVID rehab worse than cancer rehab, CDC – July 2021 13 Jul, 2021
Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021 15 Jun, 2021
COVID-19 Long haul - excellent graph - systematic review May 26, 2021 26 May, 2021
Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020 16 Apr, 2021
Probably fewer long-haul COVID-19 problems when rejuvenated immune system (Vitamin D, etc.)– Dec 2020 21 Feb, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
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Created by admin. Last Modification: Wednesday October 12, 2022 02:20:15 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
17147 EBV Cancers 2021.pdf admin 03 Mar, 2022 17:14 739.19 Kb 79
17145 EBV Atlantic March 2022.pdf PDF 2022 admin 03 Mar, 2022 14:32 1.87 Mb 76
17070 EBV 2022.jpg admin 19 Feb, 2022 21:33 149.79 Kb 234
17069 Epstein-Barr Virus and Neurological Diseases.pdf PDF 2022 admin 19 Feb, 2022 21:27 1.34 Mb 82
17068 EBV lifetime.jpg admin 19 Feb, 2022 21:13 101.98 Kb 226
17067 EBV lifetime consequences.pdf PDF 2020 admin 19 Feb, 2022 21:12 1.43 Mb 119
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