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Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019

Vitamin D levels and vitamin D receptor variants are associated with chronic heart failure in Chinese patients.

Clin Lab Anal. 2019 Feb 4:e22847. doi: 10.1002/jcla.22847.
Hao Y1, Chen Y1.

VitaminDWiki

Items in both categories Cardiovascular and Vitamin D Receptor are listed here:

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what might compensate for low VDR activation

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

 Download the PDF from VitaminDWiki
Image

Good level of Vitamin D but Ft or Tt gene mutation: every person had Chronic Heart Failure
Image

BACKGROUND:
Vitamin D is an indispensable molecule for human health. Wide ranges of diseases are linked with vitamin D deficiencies. Role of vitamin D in chronic heart failure has been demonstrated in different populations; however, reports are limited in Chinese population. Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. In the present study, we hypothesized that both vitamin D levels and VDR variants could be associated with the development of chronic heart failure.

MATERIALS AND METHODS:
We enrolled 145, chronic heart failure patients those admitted to Department of Cardiothoracic Surgery, Beijing Luhe Hospital of Capital Medical University and fulfilled NYHA inclusions criteria. In addition, ninety healthy subjects from similar geographical location were enrolled as healthy controls. Plasma levels of vitamin D were quantified by ELISA. VDR variants (BsmI, ApaI, TaqI, and FokI) were genotyped by PCR-RFLP.

RESULTS:
Plasma levels of vitamin D were significantly lower in chronic heart patients compared to healthy controls. Heterozygous and minor allele for FokI and TaqI polymorphisms were significantly higher in heart failure patients when compared to healthy controls. In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure.

CONCLUSIONS: The results of the present investigation showed an important role of vitamin D and VDR variants with chronic heart failure.

Created by admin. Last Modification: Friday July 12, 2019 02:21:10 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11639 T3A.jpg admin 23 Mar, 2019 01:05 59.16 Kb 82
11638 T2B.jpg admin 23 Mar, 2019 01:02 20.91 Kb 30
11637 T2A.jpg admin 23 Mar, 2019 01:02 49.75 Kb 31
11636 F1.jpg admin 23 Mar, 2019 01:01 18.51 Kb 76
11635 VDR Heart failure Sci-Hub.pdf PDF 2019 admin 23 Mar, 2019 01:01 139.57 Kb 42
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