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Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020

VDR gene polymorphisms as a significant factor in unexplained infertility

Gene Reports, Volume 21, December 2020, https://doi.org/10.1016/j.genrep.2020.100962
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VitaminDWiki

Fertility and Sperm category contains the following summary

117 items in Fertility or Sperm in VitaminDWiki

See also

Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
Search VitaminDWiki for IVF OR "IN VITRO FERTILIZATION" 345 items as of Sept 2019
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 77 items just in webpages as of Sept 2020
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012

Vitamin D greatly improves Fertility

Increased male Vitamin D increases fertility


Items in both categories Fertility and Vitamin D Receptor:


The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Resveratrol improves health (Vitamin D receptor, etc.) has the following

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro

The articles in both of the categories Resveratrol and Vitamin D Receptor


Vitamin D Receptor category has the following

411 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


Highlights

  • VDR-Vitamin D system takes part role in fertility and regulation of decidual cells.
  • Locally produced vitamin D related to endometrial receptivity and success implantation.
  • VDR gene BsmI and TaqI polymorphisms were a significant risk in UI.
  • VDR gene Aa genotype in ApaI polymorphism had a protective role in UI.
  • Vitamin D level could be a solution in the management of unexplained infertility.


Objectives
There are various cellular and molecular disorders of the endometrium that have been associated with unexplained infertility (UI). The physiological effects of 1,25(OH)2D3 are directed by the nuclear Vitamin D receptor(VDR). VDR gene expression and vitamin D converting enzyme have been displayed in both the proliferative and secretory process of the menstrual period in the endometrium. The study demonstrated the defects of uterine development and decidualization resulting in infertility in the VDR knockout of female mice.

Design & methods
VDR gene polymorphisms and vitamin D levels were studied in the groups, included 101 patients and 100 control, by the PCR-RFLP and the method of ECLIA. Our findings suggest that the VDR gene polymorphisms are connected with the risk of UI and, interestingly, genotypes were associated with vitamin D because serum vitamin D levels were importantly greater with Aa, Bb, TT, FF, and ff genotypes in the UI group (p = 0.001*, p = 0.001*, p = 0.002*, p = 0.004*, p = 0.003*, respectively).
We showed that

  • having the Aa genotype in VDR gene ApaI polymorphism reduced the risk of UI by 80% (p = 0.044, OR = 0.20, CI: [0.04–0.96]);
  • having the Tt, tt genotypes in VDR gene TaqI polymorphism increased the risk of UI by 4.26 times (p = 0.001 OR = 4.26, CI:[2.10–8.62])and, 4.32 times (p = 0.001, OR = 4.32, CI:[1.76–10.62]), respectively; and
  • having the BB genotype in BsmI polymorphism increased the risk of UI by 3.47 times (p = 0.005, OR = 3.47, CI:[1.44–8.36]).


Conclusion
As a consequence, impaired VDR gene expression affects the endometrial receptivity and the success of the implantation via unknown mechanisms.

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