Association between serum vitamin D and metabolic syndrome in middle-aged and older adults and role of supplementation therapy with vitamin D.
Ann Ist Super Sanita. 2017 Jan-Mar;53(1):54-59. doi: 10.4415/ANN_17_01_11.
6 months of Vitamin D
|Initial||Loading dose1||Loading Dose 2||Maintenance dose |
for remainder of 6 months
|< 10 ng||50,000 IU weekly |
|25,000 IU weekly 4 weeks||25,000 every two weeks|
|10-20 ng||-||25,000 IU weekly 4 weeks||25,000 every two weeks|
|20-30 ng||-||25,000 every 2 weeks for 8 weeks||25,000 once every 4 weeks|
Note: some other groups have all loading dosing completed in 1 week, or even one day
Study did not test vitamin D levels at the end of the 6 months, but probably those getting > 30ng of Vitamin D would have had much more than a 3 cm reduction in waist size
- Vitamins To Speed Up Metabolism And Aid Weight Loss – May 2011
- Overview Metabolic Syndrome and vitamin D
- Weight loss and Vitamin D, Calcium, and Magnesium
- Dieters lost 5 more pounds if achieved more than 32 ng of vitamin D – RCT March 2014
- Less weight gain if add Vitamin D, even if have a high fat diet (in rats) – RCT Dec 2017
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
There are many ways to get-around the Vitamin D Receptor problem
Overview Loading of vitamin D contains the following
If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically given
- Loading = repletion = quick replacement (previously known as Stoss)
- Loading doses range in size from 100,000 IU to 1,000,000 IU of Vitamin D3
- The size of the loading dose is a function of body weight - see below
Unfortunately, some doctors persist in using Vitamin D2 instead of D3
- Loading may be done as quickly as a single day, to as slowly as 3 months.
It appears that spreading the loading dose over 4-20 days is a good compromise
- Loading is typically oral, but sometimes by injection (I.M,)
- The loading dose persists in the body for about 3 months
The loading dose should be followed up with continuing maintenance
Unfortunately, many doctors fail to follow-up with the maintenance dosing.
- As about 1 in 300 people have some form of mild allergic reaction to vitamin D supplements,
it appears prudent to test with a small amount of vitamin D before giving a loading dose
- The causes of a mild allergic reaction appear to be: (in order of occurance)
1) lack of magnesium - which can be easily added
2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
- How Omega-3 fights metabolic syndrome and weight (behind paywall) – Feb 2018
- BMI reduced by Vitamin D (not much reduction – only got VitD to 26 ng) – RCT Feb 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Metabolic Syndrome with and without obesity has low vitamin D - Oct 2016
- Obese youths 2X less likely to develop Metabolic Syndrome if take Onega-3 – RCT April 2016
- Hypothesis: Energy metabolism is associated with Vitamin D – April 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- UV (perhaps Nitric Oxide) better than vitamin D at preventing obesity in rats on a high-fat diet – Nov 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- UV better than vitamin D in reducing metabolic syndrome in mice – Thesis Aug 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
- 3X more abdominal obesity among Korean children having low vitamin D – July 2012
- Overview Metabolic Syndrome and vitamin D
Images from web
Verrusio W1, Andreozzi P1, Renzi A2, Musumeci M1, Gueli N1, Cacciafesta M1.
1 Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Rome, Italy.
2 Dipartimento di Psicologia Dinamica e Clinica, Sapienza Università di Roma, Rome, Italy.
OBJECTIVES: To evaluate i) the correlation between vitamin D (vit. D) serum concentrations and metabolic syndrome (MetS); ii) the efficacy of 6 months supplementation therapy with vit. D.
METHOD: 200 patients were enrolled. Blood analyses and anthropometric measurements were carried out. Patients with hypovitaminosis D received an oral supplement therapy.
81% of the sample shows vit. D levels < 30 ng/mL. Rate of MetS was significantly higher in vit. D deficiency group than in vit D insufficiency (p = 0.009) and sufficiency (p = 0.002) groups. Vit. D shows a significant negative correlation with both waist circumference (WC) (ρ - 0.202 p = 0.004) and glycaemia values (FBG) (ρ -0.185 p = 0.009). After the supplementation therapy in a group of 60 subjects a significant increase in vit. D levels (p = 0.001) and a significant reduction in WC values (p = 0.001) were observed.
MetS, WC and FBG appeared to be associated vit. D status and it is well-known that central obesity, with the inflammatory alterations thereto correlated that determine insulin resistance, can be considered the "primum movens" for the development of MetS.
PMID: 28361806 DOI: 10.4415/ANN_17_01_11