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Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017

Association between serum vitamin D and metabolic syndrome in middle-aged and older adults and role of supplementation therapy with vitamin D.

Ann Ist Super Sanita. 2017 Jan-Mar;53(1):54-59. doi: 10.4415/ANN_17_01_11.


6 months of Vitamin D

InitialLoading dose1 Loading Dose 2Maintenance dose
for remainder of 6 months
< 10 ng50,000 IU weekly
4 weeks
25,000 IU weekly 4 weeks25,000 every two weeks
10-20 ng - 25,000 IU weekly 4 weeks25,000 every two weeks
20-30 ng - 25,000 every 2 weeks for 8 weeks25,000 once every 4 weeks

Note: some other groups have all loading dosing completed in 1 week, or even one day
Study did not test vitamin D levels at the end of the 6 months, but probably those getting > 30ng of Vitamin D would have had much more than a 3 cm reduction in waist size

See also VitaminDWiki

Overview Loading of vitamin D contains the following

Loading dose: 200 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

Items in both categories Obesity and Metabolic Syndrome are listed here:

Images from web

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 Download the PDF from VitaminDWiki


Verrusio W1, Andreozzi P1, Renzi A2, Musumeci M1, Gueli N1, Cacciafesta M1.
1 Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Rome, Italy.
2 Dipartimento di Psicologia Dinamica e Clinica, Sapienza Università di Roma, Rome, Italy.

OBJECTIVES: To evaluate i) the correlation between vitamin D (vit. D) serum concentrations and metabolic syndrome (MetS); ii) the efficacy of 6 months supplementation therapy with vit. D.

METHOD: 200 patients were enrolled. Blood analyses and anthropometric measurements were carried out. Patients with hypovitaminosis D received an oral supplement therapy.

81% of the sample shows vit. D levels < 30 ng/mL. Rate of MetS was significantly higher in vit. D deficiency group than in vit D insufficiency (p = 0.009) and sufficiency (p = 0.002) groups. Vit. D shows a significant negative correlation with both waist circumference (WC) (ρ - 0.202 p = 0.004) and glycaemia values (FBG) (ρ -0.185 p = 0.009). After the supplementation therapy in a group of 60 subjects a significant increase in vit. D levels (p = 0.001) and a significant reduction in WC values (p = 0.001) were observed.

MetS, WC and FBG appeared to be associated vit. D status and it is well-known that central obesity, with the inflammatory alterations thereto correlated that determine insulin resistance, can be considered the "primum movens" for the development of MetS.

PMID: 28361806 DOI: 10.4415/ANN_17_01_11

Created by admin. Last Modification: Thursday July 2, 2020 11:18:27 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
9132 MetS 4 cm.jpg admin 05 Jan, 2018 14.03 Kb 1292
9131 MetS Jan 2017.pdf admin 05 Jan, 2018 89.04 Kb 1007