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Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017


20% less likely to survive Pancreatic Cancer if poor Vitamin D Receptor - Aug 2018

The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
PLoS One. 2018 Aug 14;13(8):e0202272. doi: 10.1371/journal.pone.0202272. eCollection 2018.
Innocenti F1, Owzar K2,3, Jiang C3, Etheridge AS1, Gordân R2, Sibley AB3, Mulkey F3, Niedzwiecki D3, Glubb D1, Neel N1, Talamonti MS4, Bentrem DJ5, Seiser E1, Yeh JJ1, Van Loon K6, McLeod H7, Ratain MJ8, Kindler HL8, Venook AP6, Nakamura Y8, Kubo M9, Petersen GM10, Bamlet WR10, McWilliams RR10.

PURPOSE:
Advanced pancreatic cancer is a highly refractory disease almost always associated with survival of little more than a year. New interventions based on novel targets are needed. We aim to identify new genetic determinants of overall survival (OS) in patients after treatment with gemcitabine using genome-wide screens of germline DNA. We aim also to support these findings with in vitro functional analysis.

PATIENTS AND METHODS:
Genome-wide screens of germline DNA in two independent cohorts of pancreatic cancer patients (from the Cancer and Leukemia Group B (CALGB) 80303 and the Mayo Clinic) were used to select new genes associated with OS. The vitamin D receptor gene (VDR) was selected, and the interactions of genetic variation in VDR with circulating vitamin D levels and gemcitabine treatment were evaluated. Functional effects of common VDR variants were also evaluated in experimental assays in human cell lines.

RESULTS:
The rs2853564 variant in VDR was associated with OS in patients from both the

  • Mayo Clinic (HR 0.81, 95% CI 0.70-0.94, p = 0.0059) and
  • CALGB 80303 (HR 0.74, 0.63-0.87, p = 0.0002).

rs2853564 interacted with high pre-treatment levels of 25-hydroxyvitamin D (25(OH)D, a measure of endogenous vitamin D) (p = 0.0079 for interaction) and with gemcitabine treatment (p = 0.024 for interaction) to confer increased OS. rs2853564 increased transcriptional activity in luciferase assays and reduced the binding of the IRF4 transcription factor.

CONCLUSION:
Our findings propose VDR as a novel determinant of survival in advanced pancreatic cancer patients. Common functional variation in this gene might interact with endogenous vitamin D and gemcitabine treatment to determine improved patient survival. These results support evidence for a modulatory role of the vitamin D pathway for the survival of advanced pancreatic cancer patients.

 Download the PDF from VitaminDWiki


Pancreatic Cancer Meta-analysis June 2017

Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis
Oncotarget. 2017 Jun 29. doi: 10.18632/oncotarget.18888.
Zhang X1, Huang XZ1, Chen WJ1, Wu J1, Chen Y2, Wu CC1, Wang ZN3.

VitaminDWiki Summary

21% reduction in deaths, but no reduction in occurrence (study on this page)

That is, high Vitamin D blood level does not change who gets pancreatic caner, but it does increase survival

Note: Like many other diseases, how much vitamin D actually gets to the cells is far more important that how much is in blood

See also VitaminDWiki

Vitamin D Receptor category has the following

410 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Genetics category listing contains the following

281 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain


 Download the PDF from VitaminDWiki

Pancreatic cancer MORTALITY

Image

Pancreatic cancer INCIDENCE

Image

BACKGROUND:
The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.

METHODS:
A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.

RESULTS:
Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86)

Conclusions: Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.

PMID: 28733547 DOI: 10.18632/oncotarget.18888


Created by admin. Last Modification: Wednesday March 20, 2019 12:18:38 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
11617 PC VDR 2018.pdf PDF 2018 admin 20 Mar, 2019 12:17 2.65 Mb 396
8209 PC risk.jpg admin 25 Jul, 2017 15:27 41.87 Kb 819
8208 PC mortality.jpg admin 25 Jul, 2017 15:27 38.21 Kb 684
8207 pancreatic cancer mortality.pdf PDF 2017 admin 25 Jul, 2017 15:26 1.81 Mb 619
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