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Overview Alzheimer's-Cognition and Vitamin D

Table of contents

Cognitive category in VitaminDWiki starts with

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

326 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (6 studies), Genetics (8 studies), Vitamin D Receptor (15 studies), Omega-3 (48 studies), Intervention (18 studies), Meta-analyses (21 studies), Depression (21 studies), Parlinson's (16 studies),  Click here for details

Vitamin D pages containing "Dementia" in title (40 as of April 2022)
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

Types of evidence that Vitamin D helps brain problems - 2014

Low Vitamin D getting to brain cells associated with various problems

Vitamin D and neurology Wikipedia]
Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
In some cases the low vitamin D in cells is due to poor Vitamin D Receptors
Items in both categories Cognitive and Vitamin D Receptor are listed here:

Alzheimer's in VitaminDWiki

The items in both Cognition and Meta-analysis categories:

Cognition and Dementia in VitaminDWiki

Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

update at The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc. including 3 books, latest Aug 2021

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s 3 times more likely if poor VDR

Vitamin D Receptor category has the following

442 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 43 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (19 studies), Colon Cancer (11 studies), Cardiovascular (20 studies), Cognition (15 studies), Diabetes (21 studies), Hypertension (5 studies), Infant (16 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (26 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart

Alzheimer's patients had lower levels of viamin D in Cerebrospinal Fluid - Feb 2022

Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
J Alzheimers Dis. 2022 Feb 15. doi: 10.3233/JAD-215536
Jelena Zugic Soares 1 2 3, Jørgen Valeur 3, Jūratė Šaltytė Benth 4 5, Anne-Brita Knapskog 6, Geir Selbæk 2 6 7, Golchin Arefi 8, D Gregor Gilfillan 8, Anita Tollisen 3, Nenad Bogdanovic 6 9, Renate Pettersen 1

Background: Vitamin D insufficiency has been suggested as a dementia risk factor.

Objective: In this cross-sectional, explorative study we investigated whether levels of vitamin D in cerebrospinal fluid (CSF) are lower in patients with positive biomarkers of Alzheimer's disease (AD) compared to cognitively healthy controls and whether polymorphisms of the vitamin D receptor (VDR) gene, FokI, BsmI, ApaI, and TaqI, are associated with levels of vitamin D in CSF and cognition.

Methods: We included 100 patients≥65 years assessed for cognitive impairment and 76 cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D) in both serum and CSF, and VDR polymorphisms were analyzed.

Results: The mean level of 25(OH)D in serum was 78.6 (SD 28.9) nmol/l. While serum levels of 25(OH)D were not significantly different between the groups, CSF levels of 25(OH)D were significantly lower in patients with positive AD core biomarkers (p = 0.001) compared to patients without such biomarkers. Individuals with the BsmI major homozygote genotype had significantly lower results on a 10-word delayed recall test (p = 0.044) and verbal fluency test (p = 0.013), and individuals with the TaqI major homozygote genotype had significantly lower results on a verbal fluency test (p = 0.030) compared to individuals with the corresponding minor homozygote genotype.

Conclusion: Patients with positive AD core biomarkers have low CSF levels of 25(OH)D, despite sufficient serum levels. CSF levels of 25(OH)D do not seem to be affected by any of the four VDR gene polymorphisms. TaqI and BsmI major homozygote genotypes might be at increased risk for development of cognitive decline.

Playing music from a patient's youth helps with dementia, Alzheimer's, Parkinson's

On the WEB

  • Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease - Jan 2013, https://doi.org/10.1016/j.yfrne.2012.07.001
  • Vitamin D and the brain - Aug 2011 https://doi.org/10.1016/j.beem.2011.05.009
  • How Vitamin D Protects Brain Function Life Extension Magazine 2018?
  • Dementia is sometimes due to Vitamin B12 deficiency - May 2019 doi: 10.1136/bcr-2018-229044.
    • "Reversible dementia, psychotic symptoms and epilepsy in a patient with vitamin B12 deficiency"
  • Cognitive Imparement Vitamin D Council update Sept 2017
  • Is Alzheimer’s Type 3 Diabetes? New York Times Sept 2012
    • Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    • people with diabetes are at least twice as likely to get Alzheimer’s
  • PubMed Alzheimer's AND Insulin in title 299 items as of Dec 2017
    • "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
    • "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
    • "Insulin resistance in Alzheimer's disease." May 2017
  • Vitamin D and neurology WikiPedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 including vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes: should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you can be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copy of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
    • Supplementing vitamin D, etc virtually eliminates my increased risk
    • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • 7 Conditions Masquerading As Dementia GreenMed Info Aug 2018
    Does not mention which the 7 are, but does point to huge success at reversing dementia - using major changes - including supplementing with Vitamin B12, vitamin D, CoQ10 and Omega-3
  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: " Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

Clinical Trials for Cognition and Vitamin D INTERVENTION

Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki

Age-adjusted Death rates: Alzheimer's has been increasing the fastest


Big increase if both parents had Alzheimer's


54% of ALL people, of all ages, are now "touched" by Alzheimer's


Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimer's' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Health Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due to caregiving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013


Alzheimer's in more than half of hospital patients over age 65


Half of care-giving for 6+ years is due to Alzheimer's or other dementia


Work changes due to Alzheimer's or Dimentia care-giving


What if we could delay the onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
Looks like about half of the people would not have Alzheimer's costs (die sooner?)

Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag

Items in BOTH Cognition and Omega-3 categories

APOE4 gene greatly increases the risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the childbearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki

Small amount of Lithium slowed dementia in Alzheimer's

Safron treats Alzheimer's as well as drugs, but without side affects - June 2021

__Saffron Put to the Test for Alzheimer’s Dr. Greger

  • Study was funded by BIG SAFRON = Iran (not BIG PHARMA)
  • Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types - June 2020 https://doi.org/10.1111/jfpp.14629 FREE PDF
  • Note: Various suppliers of Safron in combination with Vitamin D

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017

Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"
  • Why Bill Gates-backed a $30 million fight against Alzheimer’s July 2018
    give profit incentive to groups deploying early detection of Alzheimer's
    His family (father?) has Alzheimer's

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10-year experiment, full free text online
Speed of processing training results in lower risk of dementia

Types of Mental Disorders (no mention of low vitamin D) - 2017?

Bipolar Bandit has detailed descriptions and references


Alzheimer's risk reduced by Vit D, Vit C, Omega-3, Zinc, etc more than cancels the increased risk due to APOE-4 problems - July 2018

Why Is Modern Medicine Aiming To Reduce Risk For Alzheimer's Disease With Expensive Gene Editing Technology When Fish Oil, Antioxidants & Metal Chelation Are More Effective & Economical? Bill Sardi

  1. The alternative therapies cancel the increased risk of Alzheimer's due to gene problems
    Gene Therapy ignores the other causes of Alzheimer's and other forms of dementia
  2. The alternative therapies are far far less costly than gene therapy
    might cost $200 Billion to provide gene therapy to everyone with the APOE-4 gene problem

Copper + saturated fat (cholesterol) found to increase the rate of Cognitive Decline by 3X

Alzheimer's rate especially increasing in groups at high risk of Low Vitamin D (Dark Skin)



reference for both graphics

Hallmarks of Alzheimer's Are Stimulated by This Substance Mercola
Interview of Boyd Haley, Ph.D., Video and Transcript

  • {...enzyme creatine kinase, which is a fundamental enzyme, is 98 percent inhibited in Alzheimer's patients..."
  • "All Biochemical Abnormalities and Hallmarks of Alzheimer's Are Stimulated by Mercury"
  • In 2014 Haley wrote a paper "Evidence Supporting a Link Between Dental Amalgams and Chronic Illness, Fatigue, Depression, Anxiety and Suicide."
  • "The Relationship of Toxic Effects of Mercury to Exacerbation of the Medical Condition classified as Alzheimer’s Disease" byHaley

>12 million will have Alzheimer’s in the US in 2050


Safron as good as Alzheimer's drug, but without the side effects - June 2021

  • Saffron Put to the Test for Alzheimer’s Dr Greger
    • Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial - 2014
    • Note: As of June 2021 various suppliers produce Safron in combination with Vitamin D
    • Also:"Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types" - June 2020 - https://doi.org/10.1111/jfpp.14629 PDF costs $14

Rates of Death due to Alz and Dementia vary a lot between countries

World Heath Rangings July 2021
Example: US death rate is 6X of that of Japan (34.8 vs 5.2)

Daily multivitamin slowed cognitive decline by 60%: placebo-controlled trial - Nov 2021

Multivitamins, but not cocoa, tied to slowed brain aging MDEdge Nov 11, 2021
Better and better during the trial, but plateaued at 2 years
Presented at a conference. A comment was made that the benefit might form Vitamin B12 in the multivitamin

Title change made Nov 2021 caused the visitor count to reset.
There have actually been 147521 visitors to this page since it was originally made

short url = http://is.gd/dcognition

Created by admin. Last Modification: Wednesday May 11, 2022 10:55:59 GMT-0000 by admin. (Version 404)
Overview Alzheimer's-Cognition and Vitamin D        
6189 visitors, last modified 11 May, 2022,
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Attached files

ID Name Comment Uploaded Size Downloads
15976 Dimentia Death Ratee - female.jpg admin 27 Jul, 2021 17:45 62.26 Kb 1194
15742 Alz predicted prevalence.jpg admin 13 Jun, 2021 11:34 41.38 Kb 1313
13318 Boyd Haley Alz.pdf admin 12 Jan, 2020 12:19 2.50 Mb 764
10890 Alz 2030.jpg admin 23 Nov, 2018 18:07 53.79 Kb 5061
10889 Alz dark skin.jpg admin 23 Nov, 2018 17:57 38.32 Kb 5121
9924 Mental disorders.jpg admin 04 Jun, 2018 19:10 165.44 Kb 6113
9546 Dementia vs Alzheimer's.jpg admin 19 Mar, 2018 09:19 55.26 Kb 7378
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 22:00 21.45 Kb 11189
7795 Therapeutic Benefit is in the D-Tails.pdf PDF 2016 admin 05 Mar, 2017 21:59 523.25 Kb 826
7627 Survival Of The Sickest - 2008 book.pdf PDF admin 06 Jan, 2017 22:52 947.50 Kb 11144
7553 Lithium to the Rescue.pdf PDF 2016 admin 23 Dec, 2016 12:18 670.40 Kb 1474
7407 Lithium as Nutrient - 2015.pdf PDF 2015 admin 29 Nov, 2016 11:40 128.16 Kb 1631
7406 Lithium and Alz LEF Dec 2016.pdf PDF 2016 admin 28 Nov, 2016 23:56 3.40 Mb 1930
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 14:54 15.97 Kb 9220
7255 Delay Alz by 5 years - 2015.pdf PDF 2015 admin 29 Oct, 2016 14:50 1,015.63 Kb 1972
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 14:12 19.54 Kb 9453
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 14:06 38.45 Kb 9210
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 00:04 21.84 Kb 9601
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 23:46 37.59 Kb 9526
7250 Alzheimers Association facts and figures 2016.pdf PDF 2016 admin 28 Oct, 2016 23:45 2.07 Mb 3171
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 21:22 23.01 Kb 2715
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 21:21 23.94 Kb 9231
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 21:21 31.71 Kb 10320
4867 Dementia incidence.jpg admin 12 Jan, 2015 02:24 61.75 Kb 10590
4095 Alz nutrient status.pdf PDF 2014 admin 29 Jun, 2014 10:54 1.57 Mb 2061
3475 Death rates alzheimers.gif admin 02 Jan, 2014 17:37 38.58 Kb 23679
3469 Alzheimers percentage.png admin 29 Dec, 2013 11:57 49.40 Kb 32713
1131 Alzheimer\'s 2011.pdf PDF admin 04 Mar, 2012 15:28 1.09 Mb 6913
1130 Alz in hospital - 2011.jpg Go to hospital with Alz admin 04 Mar, 2012 15:24 34.72 Kb 9763
1129 Alz how long - 2011.jpg how long care needed admin 04 Mar, 2012 15:23 28.67 Kb 9366
1128 Alz F5 - 2011.jpg increases admin 04 Mar, 2012 15:23 20.73 Kb 9671
1120 Potential targets for Alz.jpg targets from D-Mentia admin 26 Feb, 2012 21:01 21.24 Kb 12030
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 21:00 292.71 Kb 2942
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