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COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

Infect Genet Evol. 2021 Oct 2 : 105098.doi: 10.1016/j.meegid.2021.105098
Rasoul Abdollahzadeh,a,⁎,1 Mohammad Hossein Shushizadeh,b,1 Mina Barazandehrokh,c Sepideh Choopani,d Asaad Azarnezhad,e,⁎ Sahereh Paknahad,a Maryam Pirhoushiaran,a S. Zahra Makani,f and Razieh Zarifian Yeganeha


VitaminDWiki wonders which is correct in this case
1) Health Problem ==> reduces VDR activation to protect itself (as had been documented for Breast Cancer, etc)
2) Reduced VDR ==> Lower Vitamin D in cell ==> Health Problem

Apparently they are unaware of the many safe, low-cost ways to improve VDR activation
Several of the ways have been proven to fight COVID-19 in Randomized Controlled Trials

Items in both categories VDR and Virus:

Vitamin D Receptor category has the following

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

 Download the PDF from VitaminDWiki

Introduction: Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes.

Methods: In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including

  • 160 asymptomatic,
  • 50 mild/moderate, and
  • 90 severe/critical cases.

The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR).

Results: Interestingly, significant associations were disclosed for some of the SNP-related alleles and/or genotypes in one or more genetic models with different clinical data in COVID-19 patients.
Significant association of VDR-SNPs with signs, symptoms, and comorbidities was as follows:

  • ApaI with shortness of breath (P ˂ 0.001)
    • and asthma (P = 0.034) in severe/critical patients (group III);
  • BsmI with chronic renal disease (P = 0.010) in mild/moderate patients (group II);
  • Tru9I with vomiting (P = 0.031),
    • shortness of breath (P = 0.04), and
    • hypertension (P = 0.030);
  • FokI with fever and hypertension (P = 0.027) in severe/critical patients (group III);
  • CDX2 with shortness of breath (P = 0.022),
    • hypertension (P = 0.036), and
    • diabetes (P = 0.042) in severe/critical patients (group III);
  • EcoRV with diabetes (P ˂ 0.001 and P = 0.045 in mild/moderate patients (group II)
    • and severe/critical patients (group III), respectively).

However, the association of VDR TaqI and BglI polymorphisms with clinical symptoms and comorbidities in COVID-19 patients was not significant.

Conclusion: VDR gene polymorphisms might play critical roles in the vulnerability to infection and severity of COVID-19, probably by altering the risk of comorbidities. However, these results require further validation in larger studies with different ethnicities and geographical regions.

Clipped from PDF: Conclusion
Vitamin D has been shown to regulate macrophage responses, stopping them from producing excessive amounts of inflammatory cytokines and chemokines, which are common in COVID-19. Therefore, the prevalence and mortality rate of COVID-19 may depend on the modulatory effect of bioavailable Vitamin D levels of individuals, which is determined by the genetic background, such as VDR gene polymorphisms. Therefore, we designed the present study to explore the association of eight VDR gene SNPs with the clinical status and prognosis of COVID-19 patients.
We found significant associations of VDR gene variants with several clinical outcomes such as severity and shortness of breath in mild/moderate and severe/critical cases of COVID-19.
Nevertheless, the VDR gene SNPs could not be proposed as either independent or dependent risk factors to COVID-19-co-existing conditions, including hypertension, diabetes, asthma, cardiovascular disease, chronic renal disease, and malignancy.
Our data showed that some VDR SNPs have a clinical impact on the COVID-19 patients and might be helpful to identify the individuals at high risk of COVID-19 severity in the Iranian population. Moreover, the variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by vitamin D function differed by the VDR polymorphisms. However, the present study is preliminary with partially limited sample size. Thus, further experiments are suggested to identify the role of VDR polymorphisms as the cause-effect of COVID-19 severity in a larger population, in other ethnicities and geographical regions.

Attached files

ID Name Comment Uploaded Size Downloads
16372 VDR COVID_compressed.pdf admin 06 Oct, 2021 773.47 Kb 351