Cross-sectional observational study - Investigation of vitamin D concentration in Caucasian cancer patients. what is the adequate dose of vitamin D for these patients?
Clin Nutr. 2021 Apr 22;40(6):3852-3858. https://doi.org/10.1016/j.clnu.2021.04.026
Aleksandra Kapała 1, Małgorzata Szlendak 2, Ewelina Grochowska 3
- Improved long-term chemo survival if good Vitamin D (1.8 X better - Hodgkin Lymphoma) – Oct 2019
- Chemotherapy might be augmented with Vitamin D – Jan 2017
- Metastatic Cancer probably reduced by vitamin D - many studies
- Cancer patients at high risk of vitamin D deficiency were not tested as often (paradoxically) – July 2014
- Cancer - after diagnosis pages containing RADIATION in VitaminDWiki title (7 as of Oct 2021)
Many people would not have gotten cancer if they had taken enough Vitamin D years earlier
- Vitamin D prevents and treats cancer in many ways – May 2021
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- click on chart for details
This study ignored those with dark skins - who often have bigger problems with Cancer
- Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020
- Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018
- Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017
- Head and Neck Cancer associated with low vitamin D, especially with blacks - April 2012
- Overview Dark Skin and Vitamin D has
- The health disparity for dark skinned people is almost the same as whites having a low level of vitamin D
Black vs White | White - low D vs White - high D | |
breast cancer | 1.34 | 1.26 |
colorectal cancer | 1.43 | 1.44 |
cardiovascular disease | 1.29 | 1.27 |
all-cause mortality | 1.26 | 1.26 |
Many doctors prescribe enough vitamin d for healthy people - post-surgery and chemo patients need much more
Vitamin D even helps after the doctor has given up
Should consider prehabilitation - take Vitamin D BEFORE surgery
Loading doses of Vitamin D are sometimes used before/after surgeries
Cancer category starts with the following
- Cancer
290 items Overview Cancer and vitamin D - Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 items - Bladder Cancer
28 items - Breast Cancer
255 items Overview Breast Cancer and Vitamin D - Colon Cancer
142 items Overview Cancer-Colon and vitamin D - Leukemia
19 items - Liver Cancer
17 items - Lung Cancer
55 items Overview Lung cancer and vitamin D - Lymphoma Cancer
26 items - Other Cancer
66 items - Ovarian Cancer
26 items - Pancreatic Cancer
57 items - Prostate Cancer
103 items Overview Prostate Cancer and Vitamin D - Skin Cancer
121 items Overview Suntan, melanoma and vitamin D - Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
22 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Vitamin D levels drop a lot for a few months following any surgery
Vitamin D measured before surgery is not a good indicator of how much vitamin d is needed
Vitamin D levels should be > 40 ng or higher at all times
Publisher wants $36 for the PDF
2 charts from Google images
Background & aims: Vitamin D impairs tumour-related transformation and supports the anticancer function of the immune system. Currently, there are no guidelines on vitamin D supplementation devoted solely to cancer patients. The primary objective of the study was to evaluate the frequency of vitamin D deficiency in Caucasian cancer patients and to characterize the clinical factors that predispose individuals to decreased vitamin D concentration. Secondly, the study aimed to estimate the dose of vitamin D supplementation that would prevent deficiencies in patients with cancer.Methods: In the presented cross-sectional study the population consisted of 500 consecutive Caucasian patients with a diagnosis of neoplastic disease, some of which declared long-term vitamin D supplementation in various doses. Serum vitamin D concentration was measured once in all patients and clinical data were obtained from the hospital database. The frequencies of vitamin D deficiency were compared to certain clinical variables by appropriate statistical tests. The dose of vitamin D substitution in cancer patients was estimated using the receiver operating characteristic (ROC) curve.
Results:Vitamin D deficiency was diagnosed in 66.8% of patients with cancer and even in 31.6% who declared vitamin D supplementation. Older age, male gender, diagnosis of head and neck cancer or squamous cell carcinoma and body mass loss were identified as factors that predispose to vitamin D deficiency. The dose of vitamin D that would prevent deficiency in Caucasian patients with cancer was set at 2250 IU daily.
Conclusions: Vitamin D deficiency was very common in Caucasian patients with cancer, even in terms of vitamin D supplementation. The greatest predisposition was related to elder age, male gender, diagnosis of head and neck or squamous cell carcinoma and body mass loss. The dose of vitamin D supplementation in cancer patients should probably be higher than in the general population.
References
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- Vitamin D supplementation and total cancer incidence and mortality: a meta-Analysis of randomized controlled trials. Ann Oncol. 2019; 30 https://doi.org/10.1093/annonc/mdz059
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- Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2019 Jan; 380: 33-44
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- Clinical outcomes of vitamin D deficiency and supplementation in cancer patients. Nutr Rev. 2013; 71: 611-621
- Vitamin D deficiency in cancer patients and predictors for screening (D-ONC study). Curr Probl Canc. 2019; 43: 421-428
- Comparison of vitamin D levels between healthy individuals and cancer patients. Eurasian J Med Invest. 2020; 4: 259-264
- Vitamin D in head and neck cancer: a systematic review. Curr Oncol Rep. 2021; 23
- Vitamin D deficiency in head and neck cancer patients–prevalence, prognostic value and impact on immune function. OncoImmunology. 2018; 7: 1-10
- Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep. 2016; 6: 36017
- High prevalence of vitamin D deficiency in women with breast cancer: the first Chilean study. Breast. 2016; 29: 39-43
- Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies. Aging. 2019; 11: 12708-12732
- Circulating vitamin D concentration and risk of seven cancers: mendelian randomisation study. BMJ (Clinical Research Ed). 2017; 359: j4761
- Effects of vitamin D use on health-related quality of life of breast cancer patients in early survivorship. Integr Canc Ther. 2019; 18
- etc.
Cancer patients need more vitamin D, even those who are supplementing – observational study June 20218419 visitors, last modified 04 Oct, 2021, This page is in the following categories (# of items in each category)Attached files
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