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Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020

The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, BsmI, TaqI, ApaI, FokI) genes on weight loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India

Eur J Clin Nutr (2020). https://doi.org/10.1038/s41430-020-0560-4
Seema Gulati, Anoop Misra, Rajneesh Tiwari, Meenu Sharma, Ravindra M. Pandey & Ashish Datt Upadhyay


Having a poor Vitamin D receptor is one of the reasons for gaining weight

Items in both categories Obesity and Vitamin D Receptor are listed here:

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators


The aim of the present study was to evaluate polymorphisms of fat mass and obesity (FTO; rs9939609) and vitamin D receptor (VDR, FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236)] genes on weight loss after lifestyle interventions in Asian Indians.

In this 6-month pre–post intervention trial, 110 overweight/obese men and women underwent diet and exercise interventions for 180 days resulting in reduction in body weight, (5.1 kg, p < 0.001), waist circumference, and skinfolds.

Association of the following genotypes was seen in those with ≥5% weight loss:

  • TT of FTO polymorphism; 35 (81.4%) [OR (95% CI)
  • AT, 2.5 (0.6, 10.9); TT, 6.9 (1.6, 28.2); with reference to AA],
  • tt of VDR TaqII polymorphism, 12 (92.3%) [OR (95% CI);
    • tt, 32.2 (2.4, 436.4); TT, 0.5 (0.08, 3.1); all with reference to Tt],
    • bb of VDR BsmI polymorphism; 27 (65.8%) [OR (95% CI)
    • Bb, 0.2 (0.04, 0.9); bb,
    • 10.6 (0.9, 120.3); all with reference to BB] after adjusting for other genotypes.

Further, analysis of combined influence of genotypes conferring maximum weight loss showed that the following had high odds of ≥5% weight loss:

  • (1) TT of FTO gene in combination with BB/Bb of VDR BsmI and
    • TT/Tt of VDR TaqI [OR (95% CI) 5.1 (1.5, 17.4)],
  • (2) bb of BsmI and AA/AT of FTO and tt of TaqI [OR (95% CI) 3.2 (0.3, 31.7)], and
  • (3) bb of BsmI plus TT of FTO and tt of TaqI.

The above observations suggest a significant and independent role of the genotypes of FTO and VDR in influencing weight loss after lifestyle intervention in Asian Indians.

Created by admin. Last Modification: Friday January 31, 2020 21:45:44 GMT-0000 by admin. (Version 5)

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