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Vitamin D Cofactors in a nutshell

Cofactors need to be adjusted when taking a lot of vitamin D for more than a month
"A lot" is more than 4,000 IU Vitamin D daily (average)
There is virtually no agreement as how much of each cofactor is needed vs vitamin D level
The first three cofactors have, like vitamin D, greatly decreased in the human diet in the past 50 years
The goal is to restore Vitamin D, Magnesium, Omega-3, and Vitamin K back to where they had been
   in a nutshell = summed up = condensed


  • Only about 1 in 300 people seem to be allergic to Vitamin D
       but the allergic reaction is often due to lack of Magnesium
  • Magnesium increases the benefits of vitamin D by about 30% (Mg and Vit. D are synergistic)
  • Magnesium provides a great many health benefits independent of Vitamin D
  • 100 milligrams of Magnesium (say from Magnesium Chloride) seems to be enough, even with high levels of vitamin D
        see Overview Magnesium   Magnesium category has 201 items


  • Omega-3 increases active vitamin D - especially in people with poorly functioning livers or kidneys
  • 1 gram of Omega-3 seems to be enough. Note: different brands have widely different bio-availability
    I prefer Vetomega brand
  • - see Overview Omega-3  Omega-3 category has 218 items

Vitamin K2

  • K2 Keeps Calcium in bones and out of arteries
  • Calcification due to K2 deficiency may be a reason for increased mortality for some diseases for high vitamin D
  • Perhaps 100 micrograms per 2,000 IU of vitamin D (i.e. 500 micrograms for 10,000 IU of Vit D)
  • Perhaps should not take K2 concurrently with Vitamin D. Vitamin D decreases the uptake of Vitamin K1 by 50%
  • - see Overview Vitamin K2   Vitamin K category has 91 items


  • Too much Calcium is associated with cardiovascular problems years later, not stronger bones
  • Should have less than 750 milligrams of Calcium supplementation
  • Drinking a lot of water helps flush any excess Calcium from the Kidneys
  • - see Overview Calcium   Calcium category has 170 items

Boron - good, but not as essential

  • Boron increases Vitamin D and Magnesium in the body by ~ 20%
  • Most people Boron deficient now that commercial fertilizers are used
  • Should have 3-10 milligrams of Boron element daily
  • Boron can be extremely low cost, less than $0.01 a day
  • - see Boron category has 20 items


  • The cost of cofactors is 10X to 100X more than the vitamin D (in pill form, far less costly if in bulk form)
  • Many of the cofactors must be taken daily (vs weekly or bi-weekly for Vitamin D)

See also VitaminDWiki

See also web
Excellent information on virtually all supplements as well as Vitamin D

Vitamin D Cofactors in a nutshell        

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