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Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018

Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the “Mamma & Bambino” Cohort and A Meta-Analysis

Nutrients 2018, 10(9), 1172; https://doi.org/10.3390/nu10091172
Martina Barchitta 1OrcID, Andrea Maugeri 1OrcID, Maria Clara La Rosa 1, Roberta Magnano San Lio 1, Giuliana Favara 1, Marco Panella 2, Antonio Cianci 2 and Antonella Agodi 1,* OrcID
1 Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, via S. Sofia, 87, 95123 Catania, Italy
2 Department of General Surgery and Medical Surgical Specialties, University of Catania, Via S. Sofia, 78, 95123 Catania, Italy


Unfortunately this study did not report on other features associated with preterm birth
Vitamin D levels
Iodine levels
Omega-3 levels
Non-white mothers

 Download the PDF from VitaminDWiki

The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes—including preterm birth (PTB), low birth weight and small for gestational age—is currently under debate. We investigated 187 mother-child pairs from the Italian “Mamma & Bambino” cohort to evaluate the association of maternal VDR polymorphisms—BsmI, ApaI, FokI and TaqI—with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele (p = 0.040 and p = 0.010, respectively).
Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049; 95% CI = 2.606–55.709; p = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18–11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74; 95%CI 0.59–0.93) and recessive (AA vs. GG + AG: OR = 0.62; 95%CI 0.43–0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of PTB.

Created by admin. Last Modification: Friday November 15, 2019 11:37:12 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
10423 PTB VDR FOLK regressive.jpg admin 27 Aug, 2018 12:00 36.38 Kb 209
10422 VDR preterm bith Italy.pdf PDF 2018 admin 27 Aug, 2018 11:59 1.86 Mb 385
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