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MRSA Carriers not helped by 4,000 IU of Vitamin D (probably poor Vitamin D Receptor) – RCT Sept 2018

Vitamin D supplementation to persistent carriers of MRSA-a randomized and placebo-controlled clinical trial.

Eur J Clin Microbiol Infect Dis. 2018 Sep;37(9):1735-1744. doi: 10.1007/s10096-018-3306-7.
Björkhem-Bergman L1,2, Missailidis C3,4, Karlsson-Valik J5, Tammelin A5, Ekström L6, Bottai M7, Hammar U7, Lindh G8, Bergman P9,10.

VitaminDWiki

Many studies have found MRSA to be associated with a poor Vitamin D Receptor
Resveratrol is one of the ways to activate the Vitamin D receptor
   and thus get more Vitamin D to the tissues
In this study the vitamin D level in the blood was raised to a good level of 40 ng,
   which is normaly enough to have a benefit
   however the tissues containing the MRSA apparently did not get much

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what compensates for low VDR activation
Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphone and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Note: 2 ways to Improve activation of the Vitamin D Receptor:
1) Adding Reveratrol
2) Taking the vitamin D infrequently (~every two weeks) instead of daily


See MRSA, Vitamin D Receptor and Resveratrol

Unknown for MRSA
Poor Receptor ==> MRSA   OR   MRSA ==> Poor Receptor
Whereas for several Cancers
Cancer ==> Poor Vitamin D Receptor    that is, a Cancer has learned how to deactive the local VDR

 Download the PDF from VitaminDWiki
Image

Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to all beta-lactam antibiotics and can cause severe infections that are difficult to treat. Eradication strategies with conventional antibiotics are not always effective and alternative approaches are warranted. Here, we tested the hypothesis that daily supplementation with vitamin D for 12 months would reduce MRSA carriage rates among a group of persistent carriers. This was a double-blind, placebo-controlled randomized trial with n = 65 persistent MRSA carriers with 25-hydroxy vitamin D3 (25OHD) < 75 nmol/L, who were followed up with bacterial cultures at baseline and every 3 months for 1 year. The primary endpoint was the decline in MRSA positivity during the study period. The study was conducted in two MRSA outpatient clinics at the Karolinska University Hospital, Stockholm, Sweden. In total, n = 65 persistent MRSA carriers were randomized and n = 3 were lost to follow-up. Only patients deficient in vitamin D (< 75 nmol/L) were included. Vitamin D (4000 IU) or placebo/day was administered for 12 months. The decline in MRSA positivity was equal in the vitamin D and placebo group during the study period (OR, 1.00; 95% CI, 0.97-1.03; p = 0.928) and approximately 40% in both groups were MRSA-negative after 12 months. The vitamin D group produced 103 positive cultures out of 318 cultures (32.4%) from nose, throat, and perineum over the study period, whereas the placebo group produced 135/393 positive cultures (34.0%) (Fisher's exact test, p = 0.94). Vitamin D supplementation did not influence MRSA carriage. Thus, available data does not support vitamin D supplementation to persistent MRSA carriers.
Trial registration: www.clinicaltrials.gov ; NCT02178488.


Created by admin. Last Modification: Sunday July 14, 2019 18:14:13 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
12325 Challenge.pdf admin 14 Jul, 2019 15:37 869.86 Kb 111
12324 MRSA 40 ng.jpg admin 14 Jul, 2019 15:04 31.69 Kb 132
12323 MRSA RCT.pdf PDF 2018 admin 14 Jul, 2019 14:57 719.94 Kb 108
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