Irritable Bowel Syndrome and Vitamin D - many studies

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15+ VitaminDWiki pages with IBS etc. in the title

This list is automatically updated

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Role of in vitamin D in irritable bowel syndrome - April 2023

World J Clin Cases. 2023 Apr 26; 11(12): 2677–2683. doi: 10.12998/wjcc.v11.i12.2677
Xiao-Lan Yu, Qi-Qi Wu, Lian-Ping He, and Yong-Feng Zheng

Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder affecting 10%-22% of adults. Its development is closely related to the gut microbiota, and the inflammatory and immune responses triggered by the gut microbiota can lead to IBS. Vitamin D (VD) effectively treats IBS with fewer side effects by improving gut microbiota, immune regulation, and anti-inflammatory effects. In the future, it is necessary to carry out epidemiological studies on the relationship between VD and IBS, clinical studies on the efficacy of supplementing VD to improve IBS, and animal studies on the mechanism of VD improving IBS. Therefore, this paper discussed the relationship between VD and IBS.

Keywords: Irritable bowel syndrome, Vitamin D, Gut microbiota, Immune response, Mental status

Core Tip: Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder affecting 10%-22% of adults. Its development is related to the gut microbiota, and the inflammatory and immune responses triggered by the gut microbiota can lead to IBS.
Vitamin D (VD) is effective in treating IBS by

• improving gut microbiota,
• immune regulation, and
• anti-inflammatory effects.

It is necessary to carry out epidemiological studies on the relationship between VD and IBS, clinical studies on the efficacy of supplementing VD to improve IBS, and animal studies on the mechanism of VD improving IBS. This paper discussed the relationship between VD and IBS.
 Download the PDF from VitaminDWiki

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VitaminDWiki - Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – Feb 2023

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VitaminDWiki – Overview Gut and vitamin D has

• Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
• Celiac disease has a strong genetic component.
  • Most, but not all, people with celiac disease have a gene variant.
  • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
  • Celiac disease causes poor absorption of nutrients such as vitamin D.
  • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
  • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
• Review in Nov 2013 found that Vitamin D helped
  Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
• All items in category gut and vitamin D 194 items

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VitaminDWiki – Overview Gut and vitamin D has gut-friendly vitamin D information

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VitaminDWiki – Gut category listing contains

194 items in GUT category - see also Overview Gut and vitamin D,

• "Ulcerative Colitis" OR UC 839 items Jan 2020
• "celiac disease" OR CD 1830 items July 2019
• IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
• Gut-Friendly forms of vitamin D
  • such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .

See also Microbiome category listing has 32 items along with related searches.

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15,100 items in search for VITAMIN D and IBS - includes 2 meta-analyses

Google Scholar

• Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis - April 2022 https://doi.org/10.1111/jgh.15852    Download the PDF from VitaminDWiki
• The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - June 2022 https://doi.org/10.3390/nu14132618    Download the PDF from VitaminDWiki

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Asked Chat-GPT to compare IBS with IBD

Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are both chronic conditions that affect the digestive system, but they are distinct in their underlying causes, symptoms, and treatments. Here’s a comparison:

Nature of the Condition:
IBS: It is a functional disorder, which means the symptoms are not associated with any visible signs of damage or disease in the digestive tract. It affects how the bowel functions.
IBD: It is an autoimmune disease that involves chronic inflammation of the digestive tract. There is visible inflammation and damage to the digestive tract.

Common Forms:
IBS: It doesn't have different forms but can be classified based on the predominant symptom (IBS-D for diarrhea predominant, IBS-C for constipation predominant, IBS-M for mixed).
IBD: Common forms are Crohn's disease and ulcerative colitis.

Symptoms:
IBS: Abdominal pain, bloating, gas, diarrhea, constipation, mucus in the stool. The pain is often relieved by a bowel movement.
IBD: Abdominal pain, cramping, diarrhea, weight loss, fatigue, reduced appetite, blood in the stool, joint pain, and fevers.

Cause:
IBS: The exact cause is not known but it is thought to be related to a combination of abnormal gastrointestinal tract movements, increased sensitivity to pain, and possibly an imbalance of gut bacteria.
IBD: It is believed to be caused by an abnormal immune response, where the immune system attacks the cells of the digestive tract. Genetics, environmental factors, and an imbalance of gut bacteria are also thought to play a role.

Diagnosis:
IBS: Usually diagnosed based on symptoms and exclusion of other diseases. There are no specific laboratory tests to diagnose IBS.
IBD: Can be diagnosed through blood tests, stool tests, endoscopy, and imaging studies which show inflammation and damage in the digestive tract.

Treatment:
IBS: Treatment focuses on relieving symptoms. This may include changes in diet, medications to treat diarrhea or constipation, and stress reduction.
IBD: Treatment aims to reduce inflammation. This often involves medications such as anti-inflammatory drugs, immune system suppressors, and sometimes surgery to remove damaged portions of the digestive tract.

Complications:
IBS: It generally doesn’t cause complications but can significantly impact quality of life.
IBD: Can lead to serious complications such as strictures, abscesses, malnutrition, and increased risk of colon cancer.

Prevalence:
IBS: Is more common compared to IBD.
IBD: Less common but tends to be more severe.
It's important to note that although they have similarities in symptoms, IBS and IBD are fundamentally different. Proper diagnosis and management are crucial for both conditions. Always consult a healthcare provider for advice and information regarding diagnosis and treatment.