Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019

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Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma

International Forum of Allergy & Rhinology, . 2019;00:1-8.
Nesrine A. Mohamed, PhD1 and Asmaa S. Abdel-Rehim, PhD2

 Download the PDF from Sci-Hub via VitaminDWiki

Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and Apal polymorphisms and GC resistance in patients with asthma.

Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls. Atopic status was determined by skin-prick test reaction to the most common locally-encountered allergens. A GC reversibility test was performed to differentiate between GC-sensitive and GC-resistant asthma. For all subjects, analysis of the VDR FokI and Apal polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and measurement of serum 25(OH)VD levels by enzyme-linked immunosorbent assay (ELISA) were performed.

Results: The frequencies of FokI polymorphism genotypes and alleles differed significantly between patients with asthma and controls. The frequencies of the TT genotype and T allele carriers were significantly higher among patients with asthma than among controls, and also among GC-resistant patients with asthma than among GC-sensitive patients with asthma. Additionally, serum 25(OH)VD levels differed significantly among the 3 VDR FokI polymorphic genotypes in GC-resistant patients with asthma; the highest level was detected in the TT genotype. No significant differences in Apal were found.

Conclusion: We found a possible association between the Fokl T allele and GC resistance in patients with asthma. Variations in VDR Fokl might also play a role in 25(OH)VD levels. © 2019 ARS-AAOA, LLC.

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Breathing category starts with the following

414 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (130 as of Aug 2021)
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 intervention
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on chart to see the study

Overview Asthma and Vitamin D contains

• Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021
• Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
• Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
• Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
• Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
• Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
• 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
  • This list is NOT automatically updated

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The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc.  Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

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The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Has helped several people with Asthma as of Dec 2019

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VitaminDWiki - Vitamin D Receptor pages with "ASTHMA" in title

This list is automatically updated
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• PhD working at VAERS on problems with vacc system - Masterjohn interview and transcript- Dec 27, 2021
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• Far fewer vaccination antibodies against Omicron - Dec 14, 2021
• 10,000 IU of Vitamin D for 7 years with no excessive Calcium in 4,800 patients – Dec 2018
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• Omicron may require fourth vaccine dose, Pfizer says - Dec 10, 2021
• The more COVID vaccine jabs, the more Omicron infections - Dec 16, 2021
• Most of the World’s Vaccines Likely Won’t Prevent Infection From Omicron - NYT Dec 19, 2021
• Covid-Omicron cases rapidly increasing in the US - Dec 27, 2021
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• 3rd vaccination against Omicron waning in 10 weeks (2nd jab worthless at 20 weeks - UK data) - Dec 23, 2021
• 18th Vitamin D Workshop (of March 2016) abstracts – Nov 2016
• 2X more male teens died than normal in England this summer (perhaps vaccination) - Oct 2021
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• Chart of Vitamin D levels vs race - April 2013
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• COVID deaths of US seniors decreased after widespread vaccination, but INCREASED among younger – Dec 28, 2021
• Vaccine holdouts aren't Republicans, but those under age 60 where perceived risk is worse than COVID – Dec 2021
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• COVID vaccine: have warnings, all side effects reported, no mandates (Japan) - Dec 2021
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• Risk of skin cancer vs. risk of low vitamin D – Nov 2012
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• 2200X more problems from no UVB than too much UVB - WHO 2006
• More Cancer, less Solar Radiation - 1941
• Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
• Skin
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• Hard-to-heal Wounds associated with low vitamin D – review June 2021
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