Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma
International Forum of Allergy & Rhinology, . 2019;00:1-8.
Nesrine A. Mohamed, PhD1 and Asmaa S. Abdel-Rehim, PhD2
Breathing category starts with the following
- Search VitaminDWiki for Pneumonia 1,360 items as of July 2019
- Search VitaminDWiki for phrase "COMMUNITY PNEUMONIA" 99 items - Jan 2020
- Search VitaminDWiki for BRONCHITIS 272 items as of July 2019
- Search VitaminDWiki for ASTHMA in title 142 items - Nov 2019
- COPD Overview
- Search VitaminDWiki for Wheeze 1060 items as of Jan 2020
- Cystic Fibrosis category listing has
41 items along with related searches - Air Pollution reduces Vitamin D
- Note: Air Pollution reduces UVB and keeps people indoors, both reduce Vitamin D
- Smoking reduces vitamin D
Supplementing with Vitamin D will improve the health of smokers and might decease craving- Overviews at VitaminDWiki: Allergy Lung Cancer TB Asthma Influenza Colds and flu Pneumonia Respiratory infections
Overview Asthma and Vitamin D contains
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
- Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
- Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
- Vitamin D supplements could halve risk of serious asthma attacks – Cochrane conclusion – Sept 2016
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D – June 2017
- Proof that Vitamin D Works 86 health problems prevented/treated as of May 2018
Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials - Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
- Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
Meta-Analyses
- Asthmatics less able to breathe if low vitamin D – meta-analysis Nov 2019
- Asthma supplementation by Vitamin D (any amount) reduced attacks by 25 percent – meta-analysis April 2019
- Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Search VitaminDWiki for ASTHMA in title 206 items as of April 2019
- If high vitamin D during pregnancy the child is 5X less likely to get asthma
- Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 intervention
- Should Vitamin D Supplementation Be a Regular Part of Asthma Care – Oct 2013
- Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014
- All items in Breathing and Vitamin D
371 items includes Asthma, Pneunomia, RTI, TB, Allergy, COPD - Search VitaminDWiki for Wheeze 756 items as of May 2018
- Asthma much worse in city with little vitamin D – March 2014 - less UV and less outdoors ==> less vitamin D
- Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
- All items in category Autoimmune and Vitamin D
162 items - Acetaminophen (Tylenol) increases asthma wonder if Tylenol decreased vitamin D,which increases Asthma
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- The worse the bronchial asthma, the lower the vitamin D – Jan 2017
Items in both categories Breathing and Vitamin D Receptor are listed here:
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019
- Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D Receptor problems occur 5 times for often with Nasal polyposis – Nov 2016
- Vitamin D effects on lung immunity and respiratory diseases – 2011
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc. Quercetin, non-daily Vit D. Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Has helped several people with Asthma as of Dec 2019Download the PDF from Sci-Hub via VitaminDWiki
Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and Apal polymorphisms and GC resistance in patients with asthma.
Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls. Atopic status was determined by skin-prick test reaction to the most common locally-encountered allergens. A GC reversibility test was performed to differentiate between GC-sensitive and GC-resistant asthma. For all subjects, analysis of the VDR FokI and Apal polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and measurement of serum 25(OH)VD levels by enzyme-linked immunosorbent assay (ELISA) were performed.
Results: The frequencies of FokI polymorphism genotypes and alleles differed significantly between patients with asthma and controls. The frequencies of the TT genotype and T allele carriers were significantly higher among patients with asthma than among controls, and also among GC-resistant patients with asthma than among GC-sensitive patients with asthma. Additionally, serum 25(OH)VD levels differed significantly among the 3 VDR FokI polymorphic genotypes in GC-resistant patients with asthma; the highest level was detected in the TT genotype. No significant differences in Apal were found.
Conclusion: We found a possible association between the Fokl T allele and GC resistance in patients with asthma. Variations in VDR Fokl might also play a role in 25(OH)VD levels. © 2019 ARS-AAOA, LLC.
Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
Printer Friendly PDF this page! Follow this page for updates372 visitors, last modified 26 Dec, 2019, URL:
- Air Pollution reduces Vitamin D