Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019

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Influence of vitamin D receptor gene FokI and ApaI polymorphisms on glucocorticoid response in patients with asthma

International Forum of Allergy & Rhinology, . 2019;00:1-8.
Nesrine A. Mohamed, PhD1 and Asmaa S. Abdel-Rehim, PhD2

 Download the PDF from Sci-Hub via VitaminDWiki

Background: Glucocorticoid (GC)-resistant asthma, a complex disease phenotype, has a high morbidity and mortality and takes up a disproportionate share of healthcare costs. The aim of this work was to assess serum 25-hydroxyvitamin D (25(OH)VD) levels in steroid-resistant, steroid-sensitive patients with asthma and in healthy controls, and to investigate the association between the vitamin D receptor gene (VDR) FokI and Apal polymorphisms and GC resistance in patients with asthma.

Methods: This case-control study included 70 patients with severe bronchial asthma and 30 apparently healthy controls. Atopic status was determined by skin-prick test reaction to the most common locally-encountered allergens. A GC reversibility test was performed to differentiate between GC-sensitive and GC-resistant asthma. For all subjects, analysis of the VDR FokI and Apal polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and measurement of serum 25(OH)VD levels by enzyme-linked immunosorbent assay (ELISA) were performed.

Results: The frequencies of FokI polymorphism genotypes and alleles differed significantly between patients with asthma and controls. The frequencies of the TT genotype and T allele carriers were significantly higher among patients with asthma than among controls, and also among GC-resistant patients with asthma than among GC-sensitive patients with asthma. Additionally, serum 25(OH)VD levels differed significantly among the 3 VDR FokI polymorphic genotypes in GC-resistant patients with asthma; the highest level was detected in the TT genotype. No significant differences in Apal were found.

Conclusion: We found a possible association between the Fokl T allele and GC resistance in patients with asthma. Variations in VDR Fokl might also play a role in 25(OH)VD levels. © 2019 ARS-AAOA, LLC.

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Breathing category starts with the following

431 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (137 as of July 2022)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • perhaps need gut-friendly Vitamin D
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on chart to see the study

Overview Asthma and Vitamin D contains

This list is automatically updated

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The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc.  Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

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The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Has helped several people with Asthma as of Dec 2019

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VitaminDWiki - Vitamin D Receptor pages with "ASTHMA" in title

This list is automatically updated
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• Can Vitamin D Improve Your Athletic Performance (yes)
• Australian Golfers get enough vit D
• Sunscreen UVA Consumer Reports
• pigmentation and tanning perhaps 10 percent different than full spectrum
• sun cycles since 1750
• Sunbed and vit D RCT
• Not much UVB difference between Baltimore and rural
• UV does not go through clothes
• More colon and breast cancer if live in polluted city
• tanning is associated with higher levels of vitamin D in blood
• vit d correlated to fitness for post menop women
• Review of vitamin D found to help sports
• Mushroom and pulsed UV Xenon
• UVB and solar cycle
• Sun cycle NASA predictions3
• UV benefits and risks
• Tan with and without 300 nm uv
• UVB NASA based on ozone not clouds nor smog
• UV globe stripe wh .int ceh
• Health and Light
• 7 Fracture trials in Europe
• Is there evidence for vitamin D and Cognition - 2010
• Hypothesis Vitamin D and Dementia - 2009
• Vitamin D and dementia - 2010
• Vitamin D and elderly more than bone problem brain
• 50 different vit D metabolites and we are only measuring one
• Vitamin D metabolites as clinical markers
• Vitamin-Handbook 2001 chapter on Vit D
• Possible causes of vit D def in Pakistan
• Diagnosis and management of vit D def
• UVB and septicemia
• UV production of vit D indepent of skin color - 2010
• Case against Vitamin D2
• Prescription Vitamin D Not Suitable for Supplementation Say Researchers
• D2 not toxic literature review
• Vit D 1300 if lots of sun, 2100 to 3100 if little sun or dark skin
• Astronaut test of vitamin D supplementation
• Vitamin D discovery outpaces FDA decision making
• New Years Resolution take 1000 IU vit D
• 1000 IU per lb for 7 days at start of flu season
• Osteo patent prefer chewable Ca and Vit D RCT
• People with most vitamin D had telomeres associated 5 years younger
• Multivitamins and mortality
• Vitamin D Physicians and Surgeons 2009
• Perhaps showering does wash off vitamin D
• vit D conference
• Critical reappraisal of vit D deficiency
• dairy foods advances
• More evidence for vitamin D
• 2X Daily variation of vitamin D in horses - 2008

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