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TB patients had low Vitamin D and poor Vitamin D receptor – June 2019

There are two 2019 studies on this page by the same authors
Oct 2019 study has a PDF

Household contacts have high vitamin D levels AND more activated Vitamin D Receptors - June 2019

Status of vitamin D and the associated host factors in pulmonary tuberculosis patients and their household contacts: a cross sectional study
J Steroid Biochem Mol Biol. 2019 Jun 27:105419. doi: 10.1016/j.jsbmb.2019.105419
Panda S1, Tiwari A1, Luthra K1, Sharma SK2, Singh A3.
1 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.
2 Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India.
3 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India. archanasinghaiims at gmail.com.

VitaminDWiki

The abstract does not mention the possibility that TB might cause the reduction of the variables.

Items in both categories TB and Vitamin D Receptor gene are listed here:

Items in both categories TB and Radomized Controlled Trials are listed here:

Items in both categories TB and Meta-analysis are listed here:


Innate immunity plays an important role in pathophysiology of tuberculosis which is influenced by various host factors. One such factor is vitamin D which, along with its associated molecule, can alter the host defense against Mycobacterium Tuberculosis (M.Tb.) via altered production of cathelicidin and nitric oxide, both having bactericidal effect. Therefore, assessment of vitamin D and its associated molecules in tuberculosis patients and household contacts as compared to healthy controls were done and the implication of these findings in susceptibility to tuberculosis (TB) was studied. 80 active TB patients, 75 household contacts and 70 healthy controls were included. Vitamin D receptor (VDR), vitamin D binding protein (VDBP) and inducible nitric oxide synthase (iNOS) mRNA levels were studied using quantitative PCR. Serum VDR, cathelicidin, and iNOS levels were measured using ELISA. Vitamin D and NO levels were measured in serum using chemiluminescence based immunoassay and greiss reaction based colorimetry kit respectively.

Decreased serum levels of vitamin D were observed in active TB patients as compared to healthy controls (p < 0.001).
VDR and iNOS mRNA levels were found to be significantly lower in active TB patients compared to household contacts and healthy controls (p < 0.0001 and 0.005 respectively).

VDBP mRNA expression was found to be lower in active TB group as compared to household contacts and healthy controls however the difference was not found to be significant (p > 0.21). Although, mRNA expression of VDR, VDR protein and iNOS along with vitamin D levels were significantly (p < 0.05) higher in household contacts compared to active TB group.
However, levels of iNOS, NO and cathelicidin were found to be higher in TB patients as compared to household contacts and healthy controls (p < 0.01, 0.05 and 0.01 respectively). Higher levels of Vitamin D along with VDR and iNOS expression in household contacts as compared to active TB patients suggest vitamin D might have a protective role against TB plausibly decreasing disease susceptibility. Low vitamin D levels in active TB patients warrants further studies to determine the role of vitamin D supplementation in prevention and treatment of TB.


Household contacts have better Vitamin D levels andmore activated Vitamin D Receptors - Oct 2019

Association of Fok1 VDR polymorphism with Vitamin D and its associated molecules in pulmonary tuberculosis patients and their household contacts.
Sci Rep. 2019 Oct 24;9(1):15251. doi: 10.1038/s41598-019-51803-8.
Panda S1, Tiwari A1, Luthra K1, Sharma SK2, Singh A3.
1 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.
2 Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India.
3 Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India. archanasinghaiims at gmail.com.
 Download the PDF from VitaminDWiki

Status of Fok I VDR polymorphism along with vitamin D, Vitamin D receptor (VDR), and cathelicidin levels in Tuberculosis (TB) patients compared to household contacts and implication of these findings in susceptibility to TB is not known. 150 active TB patients, 150 household contacts and 150 healthy controls were recruited from North Indian population. Fok1 VDR polymorphism was studied by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP).VDR mRNA and protein levels were studied using quantitative real time PCR (q rt PCR) and enzyme linked immunosorbent assay (ELISA) respectively. Cathelicidin and Vitamin D levels were measured using ELISA and chemiluminescence immunoassay (CLIA) respectively. Significant association was found between Fok1 polymorphism and susceptibility to TB (P < 0.0005). VDR mRNA, VDR protein and vitamin D levels were significantly lower in active TB group when compared to household contacts and healthy controls (P < 0.0001, 0.0001 and 0.0005 respectively). Cathelicidin levels were higher in active TB patients compared to other groups (P < 0.0001). Expression of VDR and cathelicidin was significantly higher among 'FF' genotypes of VDR (more active form of VDR) compared to 'ff' genotype (less active form of VDR). 'f' allele was associated with increased susceptibility to TB. Higher frequency of 'F' allele, increased VDR expression along with increased vitamin D levels in household contacts compared to active TB group might be responsible for protection against active TB.


Created by admin. Last Modification: Saturday November 2, 2019 15:36:58 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
12900 TB VDR.pdf PDF 2019 admin 02 Nov, 2019 15:32 1.39 Mb 69
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