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Vitamin D resistant genes (CYP24A1, SMRT, SNAIL) – July 2022

Vitamin D resistant genes - promising therapeutic targets of chronic diseases

Review Food Funct. 2022 Jul 20. doi: 10.1039/d2fo00822j   $50 paywall
Kunnath Lakshmanan Milan 1, Ravichandran Jayasuriya 1, Kannan Harithpriya 1, Murugesan Anuradha 2, Dronamraju V L Sarada 1, Nadhiroh Siti Rahayu 3, Kunka Mohanram Ramkumar 1

Vitamin D is an essential vitamin indispensable for calcium and phosphate metabolism, and its deficiency has been implicated in several extra-skeletal pathologies, including cancer and chronic kidney disease. Synthesized endogenously in the layers of the skin by the action of UV-B radiation, the vitamin maintains the integrity of the bones, teeth, and muscles and is involved in cell proliferation, differentiation, and immunity. The deficiency of Vit-D is increasing at an alarming rate, with nearly 32% of children and adults being either deficient or having insufficient levels. This has been attributed to Vit-D resistant genes that cause a reduction in circulatory Vit-D levels through a set of signaling pathways.

CYP24A1, SMRT, and SNAIL are three genes responsible for Vit-D resistance as their activity
either lowers the circulatory levels of Vit-D
or reduces its availability in target tissues.

The hydroxylase CYP24A1 inactivates analogs and prohormonal and/or hormonal forms of calcitriol. Elevation of the expression of CYP24A1 is the major cause of exacerbation of several diseases. CYP24A1 is rate-limiting, and its induction has been correlated with increased prognosis of diseases, while loss of function mutations cause hypersensitivity to Vit-D.
The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and its corepressor are involved in the transcriptional repression of VDR-target genes.
SNAIL1 (SNAIL), SNAIL2 (Slug), and SNAIL3 (Smuc) are involved in transcriptional repression and binding to histone deacetylases and methyltransferases in addition to recruiting polycomb repressive complexes to the target gene promoters. An inverse relationship between the levels of calcitriol and the epithelial-to-mesenchymal transition is reported. Studies have demonstrated a strong association between Vit-D deficiency and chronic diseases, including cardiovascular diseases, diabetes, cancers, autoimmune diseases, infectious diseases, etc. Vit-D resistant genes associated with the aforementioned chronic diseases could serve as potential therapeutic targets. This review focuses on the basic structures and mechanisms of the repression of Vit-D regulated genes and highlights the role of Vit-D resistant genes in chronic diseases.

$95 PDF can be viewed on DeepDyve - free during trial period


VitaminDWiki - Genetics chart shows the vitamin D genes

Blood Test Misses a lot (VDW 3439)

Wonder why this study did not include the Vitamin D Receptor - that is deactivated by many diseases and easily re-activated

VitaminDWiki - Cancers might alter CYP24A1 gene

VitaminDWiki pages with CYP24A1 in title (29 as of July 2022)

This list is automatically updated

Items found: 34
Title Modified
Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023 18 Mar, 2023
No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023 11 Feb, 2023
Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022 10 Feb, 2023
CYP24A1 enzyme and Vitamin D - many studies 09 Feb, 2023
Vitamin D resistant genes (CYP24A1, SMRT, SNAIL) – July 2022 13 Dec, 2022
Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022 25 Aug, 2022
Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization – May 2022 18 May, 2022
Suicide attempts by males 3.7 X more likely if poor Vitamin D gene (CYP24A1) – Oct 2021 08 May, 2022
Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021 08 Dec, 2021
3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012 22 Jan, 2021
Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020 10 Jan, 2020
Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019 18 Nov, 2019
Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019 16 Nov, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 15 Nov, 2019
Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019 15 Nov, 2019
Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019 07 Nov, 2019
CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012 16 May, 2019
Hepatitis C 1.4X more likely if poor CYP24A1 gene – May 2019 08 May, 2019
Natural pregnancy 4X more likely if sperm had a lot of CYP24A1 – April 2019 10 Apr, 2019
Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 31 Dec, 2018
CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011 31 Dec, 2018
Maternal diabetes with poor Vitamin D gene (CYP24A1) increases risk of diabetes in female offspring by 40 percent – Jan 2018 24 Jan, 2018
Vitamin D gene (CYP24A1) changes decrease breast and pancreatic cancers – meta-analysis Nov 2017 20 Dec, 2017
Calcium problems associated with CYP24A1 (a Vitamin D gene) – Oct 2017 08 Nov, 2017
If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016 07 Jun, 2017
Rare mutation of gene (CYP24A1) results in Vitamin D accumulating in the body – Jan 2017 23 Jan, 2017
Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 30 Mar, 2016
Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015 16 Nov, 2015
Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011 16 Nov, 2015
Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012 16 Nov, 2015
Mutations in CYP24A1 gene (vitamin D) associated with kidney problems – Jan 2013 16 Nov, 2015
Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 24 Feb, 2015
Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 26 Nov, 2014
CYP24A1 gene, kidney disease, and vitamin D - May 2011 02 Nov, 2012

VitaminDWiki – Sample of Genetics studies

Vitamin D resistant genes (CYP24A1, SMRT, SNAIL) – July 2022        
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