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Overview Parkinson's and Vitamin D

Table of contents

Parkinson's Disease summary in VitaminDWiki

See also on VitaminDWiki


Those with PD have 7X higher/lower amounts of certain gut bacteria - Jan 2023

Parkinson's Disease May Start in the Gut and Spread to the Brain Trial Site News

  • "For example, the bacterial species (Bifidobacterium dentium), which is known to cause anaerobic infections such as brain abscesses, were found to be elevated seven-fold in those with Parkinson's and a 7.5-fold reduction in the bacteria such as Roseburia intestinalis which is known to be inhabitant of healthy colons (constipation is a recognized symptom of Parkinson's) was also detected."

Study = Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms - https://doi.org/10.1038/s41467-022-34667-x FREE PDF

See also: Parkinson's Disease and gut microbiome - several studies

Note: Vitamin D massively changes the composition of gut bacteria

Candidate nutraceuticals to fight PD (Oct 2022)

Vitamin D (>50 ng)
1 or more Vitamin D Receptor activators (to get more D to the brain) such as Turmeric, Curcumin, Resveratrol
Vitamin B12
Omega-3 (and decrease Omega-6)
Glutathione anti-oxidant
   perhaps inhaled Vitamin D to get more D to the brain (works in rodents)

VitaminDWiki - 12 Meta-analysis of Parkinson's studies

See also on web


Clinical Trial Effects of Vitamin D in Parkinson's Disease (PD)

Clinical Trial NCT01119131; Start Date: July 2010; Study Ongoing as of July 2015

The proposed study is a randomized, double-blinded, placebo-controlled intervention trial to measure the effects of vitamin D at (10,000 IU/day) versus placebo on balance and falls in Parkinson's disease. We will measure static, dynamic, and ambulatory balance, as well as strength, falls, and cognition before and after 16 weeks of therapy. Dynamic posturography will be used to measure static and ambulatory balance, a device called iMOBILITY will measure a timed up and go, and strength will be measured with the Biodex machine checking knee flexion and extension. Multiple quality-of-life and cognitive tests will also be performed.
Comment by VitaminDWiki - unfortunately only 16 weeks and no loading dose.
It is unlikely that very many of the participants will get a high enough vitamin D level to make any difference in 4 months.

Vitamin D Deficiency-Induced Vertebral Fractures May Cause Stooped Posture in Parkinson Disease - 2-11

American Journal of Physical Medicine & Rehabilitation:
April 2011 - Volume 90 - Issue 4 - pp 281-286
Sato, Yoshihiro MD; Iwamoto, Jun MD; Honda, Yoshiaki MD

Results: During the 5-yr study period, stooped posture developed in 34 patients; the rest of the 58 patients did not show stooped posture. At baseline, mean serum 25-hydroxyvitamin D and parathyroid hormone levels were 10.9 ng/ml and 73.1 pg/ml, respectively, in the stooped group and 18.6 ng/ml and 56.4 pg/ml, respectively, in the nonstooped group. Bone mineral density in the stooped group was significantly lower than in the nonstooped group. Dietary intake of vitamin D in the stooped group was significantly lower than in the nonstooped group.
During the study period, 19 (22%) patients in the nonstooped group developed new vertebral fracture, compared with 23 (100%) patients in the stooped group.
The mean ± SD percentage changes in bone mineral density were ?6.5 ± 0.6 in the stooped group and ?3.8 ± 0.8 in the nonstooped group.
Mean serum levels of 25-hydroxyvitamin D after 5 yrs were 7.0 ng/ml in the stooped group and 14.1 ng/ml in the nonstooped group.

Conclusions: Stooped posture in Parkinson disease may be caused by vertebral fractures resulting from vitamin D deficiency with compensatory hyperparathyroidism.
Vitamin D supplementation may reduce stooped posture in patients with Parkinson disease.
Image from the web

Age-Adjusted death from Parkinson's

22% increase in prevalence of Parkinson's(age-adjusted) 1990 - 2016
"Age-standardized prevalence rates of Parkinson's disease by country varied greater than five times, with the highest rates generally in high-income North America and lowest rates in sub-Saharan Africa

Age-Adjusted Death from Dementia (Finland)"

Dementia death rate - age standardized @is.gd/increasedisease

High prevalence of hypovitaminosis D status in patients with early Parkinson disease.

PMID: 21403017 2011  Download PDF from VitaminDWiki

Remember Vitamin D to forget Parkinson’s disease July 2012

review of 30 year study in Finland lowest levels of vitamin D were three times more likely to develop Parkinson’s, compared with the group with the highest levels of vitamin D.

What is Parkinson's (From MJ Fox)


Epidemiology and etiology of Parkinson’s disease - 2011(which does not mention vitamin D)

 Download PDF from VitaminDWiki.

Emerging role of Nutrition in PD - vitamin D and Omega-3 are mentioned - 2014

 Download PDF from VitaminDWiki.

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia

PD rehabilitation better with Virtual Reality - Review April 2021

Systemic Literature Review of the Use of Virtual Reality for Rehabilitation in Parkinson Disease
 Download the PDF from VitaminDWiki

Manganese increases the Risk of Parkinson's Symptoms (first described in 1837)

  • Excess Manganese in well water
  • Manganese is used for bleaching at pulp paper plants
    • Increased risk of Parkinson's Symptoms if work at a pulp paper plant that uses Mn
    • A friend of the founder of VitaminDWiki worked in a pulp paper plant and got PD
  • Manganese and Parkinson's: Mechanism may explain link March 2019
  • Manganese and Parkinson’s Disease: A Critical Review and New Findings - Aug 2010
    • doi: 10.1289/ehp.0901748 FREE PDF
  • Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features - July 2015
    • 10.3390/ijerph120707519 FREE PDF - Note: Parkinsonism is bilateral vs PD affects each side of the body differently
  • Parkinson-like Symptoms Worsen with Long-Term Exposure to Manganese Parkinson's Foundation - 2016
    • "manganese levels can lead to progressive parkinsonism, a disease that mirrors symptoms of Parkinson’s but is a separate disease
  • Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review - 2017
    • DOI: 10.4103/0028-3886.217949, "...The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease "
  • Metals and Parkinson’s Disease: Mechanisms and Biochemical Processes. Curr. Med. Chem. 2018, 25, 2198–2214.
  • Toxic-Induced Parkinsonism. In Movement Disorders Curricula; Springer: Vienna, Austria, 2017
  • Manganism is a neurological disorder that may occur in response to high inhalation exposures in occupational settings and which is characterized by mood changes and an extrapyramidal syndrome resembling Parkinson disease. 2015 chapter in a book
    • Clumsiness of movement 82%,Exaggeration of reflexes in lower limbs 74%, Hyperemotionalism 71%, Speech disorders 70%, Masque manganique 65%, Spasmodic laughter 47% Difficulty in certain movements 45%, Spasmodic tears 32%, Adiodokinesis 30%

PD associated with α-synuclein from colon via vagus nerve, due to more meat and less fiber - Dr. Greger Sept 2021

The Role Meat May Play in Triggering Parkinson’s Disease 5 minute video
From research by M J Fox PD foundation

"End of Alzheimers" protocol can be applied to Parkinson's too

The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
Section: Bredesen protocol and Parkinson's

Parkinson's death rate increased 63% from 1999 - 2019

Parkinson’s death rate rising, reasons unclear MDEdge Nov 11, 2021

Some Viral infections increase the risk of Parkinson's years later

All VitaminDWiki items associated with Parkinson's Disease

Associations to PD category:Cognitive 17;   Meta-analysis of Vitamin D 12;   Multiple Sclerosis 11;   Vitamin D Receptor 9;   Falls and Fractures 6;   Top news 5;   Genetics 4;   Virus 4 (as of Oct 2022)

US Parkinson's Disease: 90,000 new cases each year - Dec 2022

108 to 112 of every 100,000 age 65+
U.S. patients living with Parkinson's disease at nearly 1 million,

Read Newsmax: Study: US Parkinson's Disease Incidence 50 Percent Higher Than Previous Estimates | Newsmax.com
Urgent: Your Heart Attack Risk Determined Online - More Info

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Created by admin. Last Modification: Thursday August 10, 2023 02:18:37 GMT-0000 by admin. (Version 235)
Overview Parkinson's and Vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
15479 Parkinson's VR.pdf PDF 2021 admin 22 Apr, 2021 00:15 111.73 Kb 749
7484 Gut Parkinson's.pdf PDF 2016 admin 14 Dec, 2016 11:00 2.76 Mb 2700
5092 CoQ10 1200 mg for PD LEF 2013.pdf PDF 2013 admin 23 Feb, 2015 03:33 510.70 Kb 2959
3878 PD nutrition.pdf PDF 2014 admin 06 May, 2014 22:19 609.53 Kb 3580
3701 Epidemiology and etiology of Parkinson’s disease - 2011.pdf admin 15 Mar, 2014 02:05 956.71 Kb 4875
3456 what is parkinsons-small.jpg admin 27 Dec, 2013 14:34 191.35 Kb 14774
3455 sunshine-brain.jpg admin 27 Dec, 2013 04:21 24.13 Kb 12979
2595 Parkinson-Disease overview - 2013.pdf PDF admin 20 Jun, 2013 13:07 152.93 Kb 4503
2054 hypomimia.jpg admin 03 Feb, 2013 16:04 55.05 Kb 14507
801 Parksinsons symptoms.jpg Symptoms admin 06 Oct, 2011 20:10 9.41 Kb 16715
800 9 ng of Vitamin D with Parkinsons - 2010.pdf PDF 9 ng admin 06 Oct, 2011 14:04 286.21 Kb 3821