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Overview Parkinson's and Vitamin D

Table of contents


Parkinson's Disease summary in VitaminDWiki


See also on VitaminDWiki

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Virtually all PD patients have digestive issues (probably need gut-friendly Vitamin D) - Oct 2023

When digestive symptoms signal Parkinson’s disease MD Edge]

  • "The fact that nearly all patients with Parkinson’s disease experience digestive problems and have neuropathological lesions in intrinsic and extrinsic innervation of the gastrointestinal tract suggests that Parkinson’s disease also has a gastrointestinal component."

Overview Gut and vitamin D contains gut-friendly info:

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


Those with PD have 7X higher/lower amounts of certain gut bacteria - Jan 2023

Parkinson's Disease May Start in the Gut and Spread to the Brain Trial Site News

  • "For example, the bacterial species (Bifidobacterium dentium), which is known to cause anaerobic infections such as brain abscesses, were found to be elevated seven-fold in those with Parkinson's and a 7.5-fold reduction in the bacteria such as Roseburia intestinalis which is known to be inhabitant of healthy colons (constipation is a recognized symptom of Parkinson's) was also detected."

Study = Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms - https://doi.org/10.1038/s41467-022-34667-x FREE PDF

See also: Parkinson's Disease and gut microbiome - several studies

Note: Vitamin D massively changes the composition of gut bacteria


Candidate nutraceuticals to fight PD (Oct 2022)

Vitamin D (>50 ng)
1 or more Vitamin D Receptor activators (to get more D to the brain) such as Turmeric, Curcumin, Resveratrol
Vitamin B12
Omega-3 (and decrease Omega-6)
Glutathione anti-oxidant
CoQ10
   perhaps inhaled Vitamin D to get more D to the brain (works in rodents)


VitaminDWiki - 12 Meta-analysis of Parkinson's studies

See also on web

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Clinical Trial Effects of Vitamin D in Parkinson's Disease (PD)

Clinical Trial NCT01119131; Start Date: July 2010; Study Ongoing as of July 2015

The proposed study is a randomized, double-blinded, placebo-controlled intervention trial to measure the effects of vitamin D at (10,000 IU/day) versus placebo on balance and falls in Parkinson's disease. We will measure static, dynamic, and ambulatory balance, as well as strength, falls, and cognition before and after 16 weeks of therapy. Dynamic posturography will be used to measure static and ambulatory balance, a device called iMOBILITY will measure a timed up and go, and strength will be measured with the Biodex machine checking knee flexion and extension. Multiple quality-of-life and cognitive tests will also be performed.
Comment by VitaminDWiki - unfortunately only 16 weeks and no loading dose.
It is unlikely that very many of the participants will get a high enough vitamin D level to make any difference in 4 months.


Vitamin D Deficiency-Induced Vertebral Fractures May Cause Stooped Posture in Parkinson Disease - 2011

American Journal of Physical Medicine & Rehabilitation:
April 2011 - Volume 90 - Issue 4 - pp 281-286
Sato, Yoshihiro MD; Iwamoto, Jun MD; Honda, Yoshiaki MD

Results: During the 5-yr study period, stooped posture developed in 34 patients; the rest of the 58 patients did not show stooped posture. At baseline, mean serum 25-hydroxyvitamin D and parathyroid hormone levels were 10.9 ng/ml and 73.1 pg/ml, respectively, in the stooped group and 18.6 ng/ml and 56.4 pg/ml, respectively, in the nonstooped group. Bone mineral density in the stooped group was significantly lower than in the nonstooped group. Dietary intake of vitamin D in the stooped group was significantly lower than in the nonstooped group.
During the study period, 19 (22%) patients in the nonstooped group developed new vertebral fracture, compared with 23 (100%) patients in the stooped group.
The mean ± SD percentage changes in bone mineral density were ?6.5 ± 0.6 in the stooped group and ?3.8 ± 0.8 in the nonstooped group.
Mean serum levels of 25-hydroxyvitamin D after 5 yrs were 7.0 ng/ml in the stooped group and 14.1 ng/ml in the nonstooped group.

Conclusions: Stooped posture in Parkinson disease may be caused by vertebral fractures resulting from vitamin D deficiency with compensatory hyperparathyroidism.
Vitamin D supplementation may reduce stooped posture in patients with Parkinson disease.
Image from the web
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Age-Adjusted death from Parkinson's

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22% increase in prevalence of Parkinson's(age-adjusted) 1990 - 2016
"Age-standardized prevalence rates of Parkinson's disease by country varied greater than five times, with the highest rates generally in high-income North America and lowest rates in sub-Saharan Africa


High prevalence of hypovitaminosis D status in patients with early Parkinson disease.

PMID: 21403017 2011  Download PDF from VitaminDWiki


Remember Vitamin D to forget Parkinson’s disease July 2012

review of 30 year study in Finland lowest levels of vitamin D were three times more likely to develop Parkinson’s, compared with the group with the highest levels of vitamin D.
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What is Parkinson's (From MJ Fox)

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Epidemiology and etiology of Parkinson’s disease - 2011(which does not mention vitamin D)

 Download PDF from VitaminDWiki.


Emerging role of Nutrition in PD - vitamin D and Omega-3 are mentioned - 2014

 Download PDF from VitaminDWiki.


Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia


PD rehabilitation better with Virtual Reality - Review April 2021

Systemic Literature Review of the Use of Virtual Reality for Rehabilitation in Parkinson Disease
 Download the PDF from VitaminDWiki


Excess Manganese increases the Risk of Parkinson's Symptoms (first described in 1837)

  • Excess Manganese in well water
  • Manganese is used for bleaching at pulp paper plants
    • Increased risk of Parkinson's Symptoms if work at a pulp paper plant that uses Mn
    • A friend of the founder of VitaminDWiki worked in a pulp paper plant and got PD
  • Manganese and Parkinson's: Mechanism may explain link March 2019
  • Manganese and Parkinson’s Disease: A Critical Review and New Findings - Aug 2010
    • doi: 10.1289/ehp.0901748 FREE PDF
  • Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features - July 2015
    • 10.3390/ijerph120707519 FREE PDF - Note: Parkinsonism is bilateral vs PD affects each side of the body differently
  • Parkinson-like Symptoms Worsen with Long-Term Exposure to Manganese Parkinson's Foundation - 2016
    • "manganese levels can lead to progressive parkinsonism, a disease that mirrors symptoms of Parkinson’s but is a separate disease
  • Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review - 2017
    • DOI: 10.4103/0028-3886.217949, "...The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease "
  • Metals and Parkinson’s Disease: Mechanisms and Biochemical Processes. Curr. Med. Chem. 2018, 25, 2198–2214.
  • Toxic-Induced Parkinsonism. In Movement Disorders Curricula; Springer: Vienna, Austria, 2017
  • Manganism is a neurological disorder that may occur in response to high inhalation exposures in occupational settings and which is characterized by mood changes and an extrapyramidal syndrome resembling Parkinson disease. 2015 chapter in a book
    • Clumsiness of movement 82%,Exaggeration of reflexes in lower limbs 74%, Hyperemotionalism 71%, Speech disorders 70%, Masque manganique 65%, Spasmodic laughter 47% Difficulty in certain movements 45%, Spasmodic tears 32%, Adiodokinesis 30%

Trichloroethylene increases the risk of PD by 5X - Nov 2023

MDEdge

  • "Research done by Dr. Carlie Tanner and Dr. Sam Goldman about a decade ago showed that in twins who were exposed to this through their work (it’s widely used as a degreasing agent) or hobbies (it’s used in printing and painting, by varnish workers, or by anyone that needs it as a solvent) had a 500% increased risk of developing Parkinson’s disease. Importantly, in that study, they showed that there was a lag time of 10-40 years between exposure to that chemical and the diagnosis of the disease."
  • A good friend of the founder of VitaminDWiki worked as an engineer in a pulp paper plant that used

TCE. After retiring, he got PD. Was greatly helped by Vitamin D until his doctor forced him to take < 2,000 IU daily


PD associated with α-synuclein from colon via vagus nerve, due to more meat and less fiber - Dr. Greger Sept 2021

The Role Meat May Play in Triggering Parkinson’s Disease 5 minute video
From research by M J Fox PD foundation


"End of Alzheimers" protocol can be applied to Parkinson's too

The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
Section: Bredesen protocol and Parkinson's


Parkinson's death rate increased 63% from 1999 - 2019

Parkinson’s death rate rising, reasons unclear MDEdge Nov 11, 2021
https://doi.org/10.1212/WNL.0000000000012826


Some Viral infections increase the risk of Parkinson's years later


All VitaminDWiki items associated with Parkinson's Disease

Associations to PD category:Cognitive 17;   Meta-analysis of Vitamin D 12;   Multiple Sclerosis 11;   Vitamin D Receptor 9;   Falls and Fractures 6;   Top news 5;   Genetics 4;   Virus 4 (as of Oct 2022)


US Parkinson's Disease: 90,000 new cases each year - Dec 2022

NewsMax
108 to 112 of every 100,000 age 65+
U.S. patients living with Parkinson's disease at nearly 1 million,


PD problems reduced by Vitamin B12


VitaminDWiki – Vitamin B12 contains

Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds

  • B12 deficiency increases with age
  • B12 appears to have no toxic upper limit
  • Some people get frequent B12 injections or I.V to restore levels
    • Injection may not be needed
  • Only a small portion of B12 taken orally gets into the bloodstream
    • Sublingual B12 may not have that problem
  • B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
  • B12 deficiency symptoms include poor gut - which can reduce uptake of Vitamin D
    • unless use gut-friendly forms of Vitamin D, including topical
  • B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
    • As with Vitamin D, a massive (loading) dose can restore levels quickly
    • Nano forms of B12 are more bio-available - as with many other supplements
57 items in Vitamin B12 category on VitaminDWiki

TaiChi - 12 weeks online, reduced PD gate and posture problems - Sept 2023

Effects of a 12-week online Tai Chi intervention on gait and postural stability in individuals with Parkinson’s disease FREE PDF


Microplastics might be a cause of Parkinson's - Nov 2023

In VitaminDWiki
Nanoplastics have just been found to be in neurons of mice, causing PD like problems
No evidence of nanplastics in humans - YET.


Poor gut bacteria ==> Parkinson's? - Jan 2024

How gut bacteria connect to Parkinson’s disease Knowable Magazine
Includes link to Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms - Nov 2022 FREE PDF


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Overview Parkinson's and Vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
15479 Parkinson's VR.pdf admin 22 Apr, 2021 111.73 Kb 911
7484 Gut Parkinson's.pdf admin 14 Dec, 2016 2.76 Mb 2921
5092 CoQ10 1200 mg for PD LEF 2013.pdf admin 23 Feb, 2015 510.70 Kb 3042
3878 PD nutrition.pdf admin 06 May, 2014 609.53 Kb 3729
3701 Epidemiology and etiology of Parkinson’s disease - 2011.pdf admin 15 Mar, 2014 956.71 Kb 5039
3456 what is parkinsons-small.jpg admin 27 Dec, 2013 191.35 Kb 15195
3455 sunshine-brain.jpg admin 27 Dec, 2013 24.13 Kb 13346
2595 Parkinson-Disease overview - 2013.pdf admin 20 Jun, 2013 152.93 Kb 4631
2054 hypomimia.jpg admin 03 Feb, 2013 55.05 Kb 14879
801 Parksinsons symptoms.jpg admin 06 Oct, 2011 9.41 Kb 17094
800 9 ng of Vitamin D with Parkinsons - 2010.pdf admin 06 Oct, 2011 286.21 Kb 3969