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Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019

New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies

Journal of Human Genetics (2019) doi:10.1038/s10038-019-0702-5
Songcheng Yu, Xing Li, Fei Yu, Zhenxing Mao, Yan Wang, Yuan Xue, Hualei Sun, Yue Ba, Chongjian Wang & Wenjie Li


The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, non-daily Vitamin D dosing, curcumin, intense exercise, etc
   Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Items in both categories Obesity and Vitamin D Receptor:

 Download the PDF from Sci-Hub via VitaminDWiki
Siblings in the same family are obese if poor VDR

Association between vitamin D receptor (VDR) genetic polymorphism and obesity was observed in several case-control studies. This study hypothesized that these associations could be verified in family-based study. We aimed at investigating the associations between VDR SNPs and obesity (BMI ≥ 28 kg/m2) by case-control study with 688 subjects and family-based study with 419 pedigrees. The results of case-control study suggested that rs3847987 (AC vs CC, Adjusted OR: 1.938, 95% CI: 1.359–2.763, P = 0.000405) was associated with obesity. Allele C of rs3847987 was risk factors for obesity (P = 0.006). Furthermore, association of rs3847987 with BMI was verified in family-based study (Z = 2.077, P = 0.037811). In addition, sibling with AC genotype of rs3847987 had significant higher BMI than CC genotype in the same family (P = 0.03). Therefore, it could be concluded that VDR genetic polymorphism (rs3847987) may be associated with obesity.


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Created by admin. Last Modification: Wednesday December 11, 2019 12:49:13 GMT-0000 by admin. (Version 4)

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13135 VDR BMI.jpg admin 11 Dec, 2019 12:46 9.04 Kb 432
13134 VDR obesity sci-hub.pdf PDF 2019 admin 11 Dec, 2019 12:45 419.89 Kb 472