Potential Molecular Mechanisms of the Anti-cancer Activity of Vitamin D
Anticancer Research 39: 3353-3363 (2019). doi: 10.21873/anticanres. 13478
DOROTA SKRAJNOWSKA and BARBARA BOBROWSKA-KORCZAK
Department of Bromatology, Medical University of Warsaw, Warsaw, Poland
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Vitamin D, or more precisely its active metabolite calcitriol (1,25-(OH)2D3), plays a fundamental role in bone metabolism and differentiation as well as in intestinal absorption of calcium and regulation of calcium-phosphate metabolism. Recent decades have brought about the discovery of the role of calcitriol in processes regulating cell differentiation, proliferation, angiogenesis and apoptosis. This creates the potential for numerous therapeutic applications of vitamin D in diseases associated with autoaggressive immune responses or in cancer. This study presents selected issues regarding current knowledge of the anti-cancer mechanisms of vitamin D.
Sections = ways
Vitamin D - Cell Cycle Regulation
Nuclear Vitamin D Receptor (nVDR)
Vitamin D - Apoptosis Induction
Vitamin D - Inhibition of Invasiveness and Metastasis of Tumours
Vitamin D - Angiogenesis Inhibition
Inhibition of Hedgehog (Hh) Signaling by Vitamin D
Interaction of p53 and VDR Signaling
Vitamin D - Interaction of Photocarcinogenesis
Conclusion
On the basis of current data, it cannot be stated conclusively whether intake of vitamin D may offer protection against cancer. The presence of the VDR throughout the body and the effect of vitamin D on the cell cycle, apoptosis, angiogenesis, Hh signaling, interaction of p53 and photocarcinogenesis unquestionably suggest such a potential. However, further research is required, first to fully elucidate the mechanisms of action of this vitamin, and secondly to determine a specific dose and time of intake necessary to achieve an anticancer effect.8 ways that Cancer might be prevented by Vitamin D - June 20192165 visitors, last modified 30 Dec, 2019, This page is in the following categories (# of items in each category) - Breast Cancer and VDR