Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders
Int. J. Mol. Sci. 2017, 18(11), 2340; doi:10.3390/ijms18112340
Julia Knabl 1,2, Aurelia Vattai 1, Yao Ye 1, Julia Jueckstock 1, Stefan Hutter 1, Franz Kainer 2, Sven Mahner 1 and Udo Jeschke 1,* OrcID
1 Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany
2 Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany
(This article belongs to the Special Issue Vitamin D and Its Analogues: New Insights on Biological Effects and Therapeutic Uses)
Pages listed in BOTH the categories Pregnancy and Vitamin D Receptor
- Poor placental Vitamin D genes associated with gestational diabetes and preeclampsia - April 2023
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
Download the PDF from VitaminDWiki
Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It
- regulates decidualisation and implantation,
- influences hormone secretion and
- placental immune modulations.
This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as
- preeclampsia,
- fetal growth restriction 5 % of pregnancies
- gestational diabetes 3% to 8% of pregnancies
- preterm birth.
We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
Clipped from PDF
- “FokI variant could be linked to an increased risk of preterm birth (odds ratio OR = 3.317)”
The above is the only quantitative data which was quickly noticed in the study