Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.
J Ovarian Res. 2013 May 26;6(1):37.
Mohapatra S, Saxena A, Gandhi G, Koner BC, Ray PC.
INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.
OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.
MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.
RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype.
Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4).
CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.
PDF is attached at the bottom of this page
Second study one month later (June 2013) is also attached at the bottom of this page
Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis PLOS ONE
See also VitaminDWiki
- Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action. – 2014
- Ovarian cancer: more likely to survive if more vitamin D – Aug 2012
- Calcium and vitamin D appear to be among the few ways to prevent ovarian cancer – 2010
- Ovarian Cancer is somewhat associated with a reduction in 20 ng of vitamin D – Feb 2011
- Difference in Fok gene reduced response to vitamin D by 35 percent – Nov 2012
- All items in category Genetics and Vitamin D
- Search VitaminDWiki for Fok1 91 items as of Feb 2017
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
Vitamin D Receptor category has the following
470 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problemsSee also:
A poor VDR restricts Vitamin D from getting in the cells
44 studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
17 studies), Breast Cancer ( 20 studies), Colon Cancer ( 13 studies), Cardiovascular ( 22 studies), Cognition ( 16 studies), Diabetes ( 22 studies), Hypertension ( 7 studies), Infant ( 18 studies), Lupus ( 6 studies), Metabolic Syndrome ( 3 studies), Mortality ( 4 studies), Multiple Sclerosis ( 11 studies), Obesity ( 15 studies), Pregnancy ( 22 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 30 studies), Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement Sun
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDROvarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
7857 visitors, last modified 14 Dec, 2017,This page is in the following categories (# of items in each category)
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